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- Review of the endoscopic and medical management of non-variceal Upper Gastro-intestinal Bleeding
Abstract : Acute Upper Gastro-intestinal bleeding(UGIB), defined as bleeding from a source that is proximal to the ligament of treitz, is a potentially life threatening medical emergency. The underlying pathophysiology of non-variceal upper GI bleeds involve either arterial haemorrhage, such as in mucosal tears or GI ulcers, or v..
- Comparison of Analytical Techniques for Thermal Stability Analysis of Beta-Cyclodextrin for an Ebola Virus Infection Treatment
ABSTRACT: Each New Drug Application filed with the Food and Drug Administration (FDA) must include the analytical procedures to ensure the identity, strength, quality, purity, and potency of a drug substance and drug product. The BSN389 drug product (being developed to treat Ebola virus infections) includes beta cyclodextrin..
- Setting Starting Level for a Trial of a Biofilm-Disrupting Adjuvant
Abstract: Combination therapy is beneficial treatment modality for multiple diseases. Cinnamon oil may be an advantageous agent in a number of combination therapies as cinnamon oil has antibacterial activity. Cinnamon oil has also been shown to be effective against biofilm cultures of Streptococcus mutans and Lactobacillus plant..
- Characterization of BSN175: A Drug to Treat Prader-Willi Syndrome
ABSTRACT: The purpose of this research is to choose the best analytical method for determining stability of BSN175. This research uses an accelerated stability study to compare the decomposed and stable drug using IR and 1H NMR spectroscopy. The Bootstrap Error-adjusted Single-sample Technique (BEST) was used to compare the effe..
- The Core Question Named "Whydunit"
My opinion: I am addicted to reading because I am addicted to exploring. Recently I read three books, not in a particular sequence, which aligned my line of thought to a tee. The first book was The Alienist by Caleb Carr [1], read after religiously watching television series, The Alienist on TNT [2], a cable television network. Th..
- Ask Joint Commission: What Say When Overlay?
Abstract: The prevalence of overlays (overwriting) in electronic medical record (EMR) system has been well established. The literature is abundant in regards to the consequences of overlays for patient safety, the technical costs of cleaning EMR from its overlays, and the essentiality to prevent overlays. However, it is not clea..
- Freedom for Vacation with Telehealth
My opinion: Documentation in recent medical literature about successful exploration of telehealth for distant and poorly accessible geographical regions' patients' primary care's continuity has intrigued us.1 It has made us wonder if this avenue can be explored from primary care physicians' personal perspective wherein telehealth ..
- Do Operating Room Work Environments Associate With Personnel's Contact Lenses' Abandonment? A Questionnaire Study Worth Exploring
Background: Since the time when our department's paper [1] was published about the potential incidence of dry eye problems in relation to operating room environments, the thought process has been in the need for further clinical research investigation. To gauge the potential of our operating room environments possibly affecting th..
- Are We Prescribing More Than 3-Days Worth Opioids' Prescriptions To Our Outpatient Surgical Patients When Discharged On Day Of Surgery? A Quality Improvement Study Worth Exploring
Background: Since the time when Centers for Disease Control and Prevention (CDC) came up with the guidelines [1] to further responsible attitude towards opioid prescriptions in acute pain settings, we have been wondering the status of awareness among opioid prescribers in our institution as well as their responsiveness to the CDC .. - Avascular Necrosis (AVN) of the Coccyx as a Cause of Coccydynia (Tailbone Pain)
Abstract : Introduction: Coccydynia (coccyx pain, tailbone pain) has many etiologies. Avascular necrosis (AVN, osteonecrosis) of the coccyx is a rarely reported cause of coccyx pain. Case report: We present a case of a 35-year-old male who presented with complaints of four years of worsening coccyx pain. He had a history of bilat..
- Rehabilitation Models of Mechanisms, Preventions and Treatments of Amyotrophic Lateral Sclerosis Caused by Toxic Invasions
Abstract : Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive and fatal neurodegenerative disorder; there is no cure for ALS to date and the causes of this degeneration are still unknown. In this..
- Obtaining a clearer perspective on the differently abled: a case study from a Caribbean medical school
Abstract : Movies are used in medical schools for a variety of purposes ranging from learning of professionalism, public health, drug dependence, disability among others. In a medical school in Aruba, Dutch Caribbean movies and activities were used to strengthen learning of communication skills, empathy, professionalism, and deat..
- Audit of Maternity Care Outcomes Using the Moving Average Technique
Abstract: Maternity audits are typically shown as monthly figures. These often show spuriously high or ow values. The aim of this study was to audit maternity outcomes over time by applying the moving average technique. This audit of maternity outcomes was conducted at the Nepean Hospital in Sydney, Australia. Variables included..
- Modeling Working Mechanisms of Human Cochlea
Abstract: To keep healthy people from auditory dysfunction such as hearing loss, tinnitus et al, it is significant to understand the working mechanisms of the cochlea. Bekesy discovered the physical mechanism o..
- Relationship between Caregivers' Socio-Economic Status and Childhood Tuberculosis in Bauchi State, Northeastern Nigeria
Abstract: Background:Childhood tuberculosis (CTB), remains a neglected aspect of the TB epidemic despite accounting for 10% of the global TB burden and being responsible for 210,000 deaths in 2016. Furthermore, TB research, prevention, and control worldwide has predominantly focused on adults, neglecting children 0-14 years o..
- A Novel Statistical Approach to NOAEL: QBEST Applied to Dosing of Ellagic Acid
Abstract: QBEST, a novel statistical method, can be applied to the problem of estimating the No Observed Adverse Effect Level (NOAEL) of a New Molecular Entity (NME) in order to anticipate a safe starting dose for beginning clinical trials. The NOAEL from QBEST (called the QNOAEL) can be calculated using multiple disparate studi..
- Transcatheter Uterine Artery Embolisation as a Treatment for Uterine Adenomyosis: A Case Report
Abstract : Background Transcatheter uterine artery embolisation (TUAE) was reported to be clinically effective in women with uterine adenomyoma (UA) and heavy menstrual bleeding. However, if symptoms remain after TUAE, hysterectomy is ultimately required. Therefore, TUAE has not been officially recognised as a UA treatment. Metho..
- Comparative all-cause and cause-specific mortality for National Basketball Association players, 1970-2012
Abstract: Prior reports of the mortality experience of professional basketball players have suggested that players in the National Basketball Association have mortality rates lower than those of the US general population. Here we analyze NBA player vital data between 1970 and 2012 to provide all-cause and cause-specific standard..
- Let There Be Guideline For Being Too Clean
My opinion: As interestingly brought to light by Svanes et al (2018) [1] and others [2-3], the time has been ripe for eliciting a discussion about the consequences of cleaning when with time, being too clean has been slowly replacing being too dirty [4-5]. To my limited understanding, the mechanical agents may elicit harm within m..
- Video Phone Communication With Patients In Isolation
Abstract: The most stringent isolation precautions (airborne precautions) warrant the most commonly used N95 respirators to be worn by healthcare providers in negative pressure rooms caring for patients suspected or confirmed to be harboring airborne pathogens. However, although N95 respirators aim to protect healthcare provider..
- Audio-Video Recording The Consenting Process With Futuristic Air-Gapped Dedicated Devices
Opinion: As anesthesiologists working in perioperative areas, the question that constantly lingers is how to judge the capacity of perioperative patients to consent for the procedures they are presenting for and the procedures they may need emergently. Even though these questions might not have been traditionally related to ane..
- Progress Bar On ERAS Portal
Opinion: The variable application fees' model of Electronic Residency Application Service (ERAS) might be expecting that the fees per application becoming higher with increasing number of applications per specialty may deter the number of applications per applicant from soaring. However, this ploy to control the number of appli..
- Save The Hands While Saving From Hands
Abstract: There has been escalating stress on hand hygiene to ensure prevention of disease-transmission. However, it is time to concurrently give due consideration to counter-concerns inherent with hand hygiene precautions and hereafter, possibly suggest an alternative solution. Although gloves have been in use as barrier method..
- Incidence of Heparin-Induced Thrombocytopenia and "Argatroban" Dollars At University Hospital In The United States
Abstract : Background: According to published medical literature, there is variable incidence of heparin-induced thrombocytopenia (HIT), a life-threatening pro-thrombotic state, complicating unfractionated heparin (UFH) or low-molecular weight heparin (LMWH) use with immunogenic activation cascade evolving into arteriovenous thro..
- I do not believe (have faith) in this: Can I say NO?: Future of Post-Hire Post-Market-Safety-Surveillance (PMSS) for Physicians
My opinion: When the author had conceptualized post-hire Post-Market-Safety-Surveillance (PMSS) [1] for physicians in general and operating room personnel in particular wherein their co-workers and supporting staff may futuristically rate the individuals in question regarding how likely the rating personnel may consider the rated ..
- nil-per-os (NPO): Can We Address It? With A Loco-Regional-National Database
My opinion: Although the term "Say No To NPO!" has been registered as a trademark by BevMD LLC, California, United States,[1] the American Society of Anesthesiologists (ASA) should envision progressing towards it while balancing the dynamically evolving pros-cons evidence for preoperative hydration-nutrition status with pulmonary ..
- Scopolamine and Sugammadex: Gateway To Litigation In Absence of Patient Education
My opinion: As an anesthesiologist, my personal experience with scopolamine transdermal therapeutic system (TTS) patch as a counter-measure against postoperative nausea and vomiting (PONV) and sugammadex as a rapid reversal agent against neuromuscular blockade is limited. Still, I wonder if these medications can be gateway to liti..
- Self-Pay All Along
My opinion: Being an avid reader, I stumbled onto the health insurance practice of ASO [1]. As a healthcare consumer, it is important to know what ASO is. The acronym ASO stands for "Administrative Services Only" [2], a practice that has figuratively evolved the majority of our employers into becoming our health insurance carriers..
- Gender Differences in Comorbidities of Heart Failure Patients with Preserved or Reduced Left Ventricular Ejection Fraction
Abstract: Introduction/AimThe aim of this study was to establish gender differences in the comorbidities of heart failure (HF) patients both with preserved (HFpEF) or reduced (HFrEF) left ventricular ejection fraction Materials and MethodsThis is a retrospective study including 535 heart failure patients hospitalized in the pe..
- Uterine giant myomectomy: A case report
Abstract: Background Uterine leiomyomas, the most common benign gynecological tumor, usually occur in females of reproductive age. Myomectomy is the preferred surgical treatment in reproductive-aged women who want to retain their uterus. Myomas can range in size from as small as an apple seed to as large as a melon. Giant uterin..
- Gemcitabine-induced haemolytic uremic syndrome: high level of suspicion seems crucial
Letter to the editor: Dear editor, Gemcitabine is an antimetabolite agent used in the treatment of many tumours. The safety profile of gemcitabine is generally mild and it usually displays minimal toxicity in elderly too. Furthermore, its profile of side-effects does not seem to be related to patient’s age. There is no evidence of cumulat..
- Sciatic neuritis due to fibrovascular bands and myxoid neurofibroma. Arthroscopic decompression and excision
Abstract : A 34-year-old lady was referred to our clinic due to a chronic hip and leg pain that did not improve with rehabilitation and after three corticosteroid injections. The MRI showed sciatic neuritis and ..
- Chemotherapy induced oral mucositis: prevention is possible
Abstract : Oral mucositis (OM) is a frequent side-effect of antineoplastic treatments. Patients usually describe the first symptom as burning sensation in the mouth and swelling, erythema or ulceration and pain will follow. These will place them at a higher risk of infection, might impair significantly their nutritional status a..
- Biological microworld vis-a-vis astrophysical world of gravitation
Abstract: On completion of few decades of in-house as well as outdoor investigations, the author has come out with the opinion that various little understood phenomena in life science could be compared and explained through gravitation based astrophysical principles. Gravitation plays an extensive role in astrophysical world i..
- Clear Aligners: strenghts and weaknesses
Abstract : Clear aligners are orthodontic devices that use elastic thermoplastic material that applies pressure to the teeth to move into the aligner’s position, which are an alternative to dental braces. They are esthetic, efficient, and comfortable compared to traditional fixed appliance for mild-to-moderate malocclusion. Cle..
- Retention after orthodontic treatments: a systematic review
Abstract : Orthodontists should work to achieve an occlusion that is functionally efficient, esthetic, and healthy. Long-term retention helps to ensure stability of the dentition. ..
- Dental transpositions: a systematic review
Abstract : Tooth transposition is a form of ectopic eruption that requires an intensive exploration of treatment options prior to treatment. Treatment options include alignment of teeth in their transposed positions, extraction of one or both transposed teeth, or orthodontic movement to their proper positions in the arch. If a pr..
- The Diode Laser: A useful aide for esthetics in orthodontics
Abstract : Contemporary orthodontics continues to merge with modern-day technology and the growing focus on dental esthetics in today’s culture. Laser technology got in these years a more and more important role in modern dentistry and, recently, also in orthodontics the utilization of laser devices was proposed. In the last tw..
- Effects and long-term stability of functional treatment with removable appliance for Class II Malocclusion
Abstract : Class II malocclusion is not a single entity but results from numerous combinations of both skeletal and dental alveolar components. Treatment of Class II malocclusions may involve functional appliance therapy. Ideally this therapy should be started in the late mixed dentition followed by Phase II therapy to align perm..
- SECOND MOLAR IMPACTION WITH LIP BUMPER THERAPY
Abstract : Mandibular lip bumpers (LBs) can provide significant clinical gain of mandibular arch perimeter during mixed-dentition. However many orthodontists do not use them due to the possibility of permanent second molar (M2) eruptive disturbances...
- Effectiveness of Rapid Palatal Expansion in patients affected by OSAS
Abstract : The diagnosis of OSAS (Obstructive Sleep Apnea Syndrome) in childhood is becoming always more frequent, with more than 1000 articles written between 2000 and 2017. Many symptoms characterize this syndrome and many benefits in its treatment can be achieved through orthodontics, in particular, orthopedic expansion of max..
- Condylar Hyperlasia:Diagnosis and Treatment, a review
Abstract : Unilateral condylar hyperplasia is an unbalanced bone growth of one condyle rather than the other one clinically resulting as a facial asymmetry, whose characteristics are different depending on the direction of the hyperplasia.The purpose of our study is a literature review resuming the most important characteristics ..
- SELF-PERCEPTION OF MALOCCLUSION SEVERITY: IOTN-AC
Abstract : The purpose of orthodontic treatment is to get a functional occlusion and a good aesthetic result. More and more patients require orthodontic treatment and the main motivation is the improvement of smile aesthetics. Over the years, numerous indices have been developed to rank or score the severity of a malocclusion rel..
- Evaluation of the prevalence of malocclusions based on the Index of Orthodontic Treatment Need (IOTN): a review of the literature.
Abstract : The purpose of orthodontics consists in the correction of malocclusions. It was therefore decided to carry out a review of the literature to assess the prevalence of the different malocclusions especially according to the Index of Orthodontic Treatment Need (IOTN). The prevalence of malocclusion also depends on the typ..
- The study of the palatal vault morphology
Abstract : The palate growth was a topic of interest for orthodontic literature because palatal dimensions often need to be modified during orthodontic or surgical-orthodontic treatment. The study of the morphology of the palate vault has been subjected to different researches with more sophisticated methods on plaster models (th..
- Digital models in orthodontic diagnosis: a review
Abstract : Objective: the purposes of this review is to evaluate the validity and reliability of orthodontics measurements on digital models Materials and methods: rating of studies present in literature from 2003 to 2016, that evaluate the validity and reliability of orthodontic space analysis on digital models. Results: digital..
- Spect bone scintigraphy in the diagnosis of unilateral condylar hyperplasia: a systematic review
Abstract : Unilateral condylar hyperplasia is an uncommon condition with unknow aetiology which causes overdevelopment of condyle leading to facial asymmetry, mandibular deviation, malocclusion, and articulation dysfunction. The comparison of radiographs and clinical photographs is considered the current accept standard for the d..
- Borderline patients between orthodontics and surgery: review
Abstract : Borderline is the term used to refer to cinical cases in which the prognosis and the best therapeutic plan are uncertain. Our aim should be to reduce as far as possible the range of values characterizing borderline pathologies and thus to increase the number of patients receiving precise diagnosis and certain therapeut..
- A solution to the problem of frictional resistance with self-ligating system: a systematic review
Abstract : During the early stages of orthodontic treatment, the self-ligating system is more efficient because a reduction of friction in the interface archwire-bracket occurs. The friction is determined by three components: friction, binding and notching; it depends on the critical contact angle defined, for each pair of wire a..
- The versatility of the 2X4 appliance
Abstract : Early diagnosis and treatment are fundamental in order to reduce the severity of a malocclusion. In three of most common conditions (anterior crossbite, posterior crossbite and impacted/ectopic incisors) a 2X4 fixed appliance can be very useful with some advantages compared to removable appliances...
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