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- A brief overview of the role of CA 15.3 in breast cancer
Review: Cancer antigen 15-3 (CA 15-3) is an epitope of the transmembrane glycoprotein MUC1 (mucin 1 or polymorphic epithelial mucin). Mucins line the surface of epithelial cells in several organs and protect the body from infections as prevent the pathogen from reaching the cell surface. It is overexpressed in several cancer..
- Tyrosine kinases inhibitors: interactions and safe use
Abstract : Tyrosine kinases inhibitors (TKI) are small molecules that interfere with cell signalling and target selected malignancies. The concern associated with oral drugs is related to their low and unpredictable bioavailability. In the past years, several TKI have been introduced in oncology and the risk of serious drug-drug ..
- Wormhole of Mind
My opinion: I never realized that my recent awakening about the existence of Einstein-Rosen bridges (wormholes) in the space-time fabric will lead me to revisit one of my all time favorite movie - Ghost (1990) [1]. When Sam the Ghost is searching for poltergeist in the subway, it was portrayed that while standing on the subway pla..
- Naming the nomenclatures: Dotting the Antidotes, Antagonizing the Antagonists
My opinion: In our pursuit to explore and explain for ourselves about what happens if the "antagonists" are administered prior to the "agonists", we realized that we may have been naming our medications incorrectly although it can be considered honest mistake or outright ignorance on our behalves. The medications that initiated an..
- Water or Wipe: Implications for Human Papilloma Virus Associated Cancers?
Abstract: It's commendable statistic that was deciphered by Islami et al (2016). It is interesting question raised by them whether the trends of receptive anal intercourse may explain the trends towards anal cancer incidence among various countries. However, they could have also reflected in their discussions whether plain water..
- Is It Time to Review The RUSH For Start Times in Operating Rooms from Patients' Perspectives? Our Limited Data Results Over One Month Period Based On Yes-No-Don't Know (YNDK) Scale
Introduction: Quality assurance (QA) has become an essential ingredient of healthcare delivery. QA methods can review patient safety processes for patients across various healthcare locations [1-10], QA also involves catering to the patient satisfaction scores. One of the initiative for peri-operative efficiency and time management ..
- Relationship between the tongue posture and positional vertigo
Case Report: This is acase report and the illustrations attached in the article...
- A case study of teaching research methods in health promotion to African American doctoral students
Abstract: It is challenging for doctoral level programs in public health and health promotion to build advanced level research competencies in minority students. The purpose of this case study was to present a research methods course that caters specifically to African American doctoral students and builds health promotion compe..
- Endoscopic third ventriculostomy in tuberculous meningitis with hydrocephalus-An Indian experience
Abstract: Introduction- Hydrocephalus is one of the commonest complications of tuberculous meningitis (TBM). Endoscopic third ventriculostomy (ETV) has evolved as an alternative to shunt surgeries for obstructive hydrocephalus in TBM. It offers the opportunity to keep the patient free of foreign material and its associated compl..
- To be, or Not to be - Apt William Shakespeare HAMLET Words Define Cardiopulmonary Resuscitation - CPR - Scenarios in India
My Opinion: Joshi (2015) [1] prospectively investigated cardiopulmonary resuscitation (CPR) in an Indian hospital scenario. However, the paper did not provide the reasons why 153 out of 413 in-hospital “witnessed” arrests were not considered for resuscitation attempts (the numbers, who did not qualify for CPR after in-hospital..
- Unilateral Hearing Loss Following Carbon Monoxide Poisoning
Abstract : The ototoxicity associated wih carbon monoxide is rare and is usually associated with chronic exposure. The pathophysiological mechanisms include hypoxia due to decreased import of oxygen and free rad..
- Evaluation of Different Adhesive Systems on Dentin Bond Strength
Abstract: The objective of this paper was to compare the in vitro effect of a conventional and three self-etching adhesive systems as regards bond strength to human dentin substrate by means of the microtensile test. A total of eight sound third molars were used. The teeth had their roots embedded in acrylic resin and underwent ..
- Unicorn of Anesthesia: Can Mythical cumulative electromagnetic Vector of Human Brain explain induction- Reversal of Anesthesia?
Abstract: There is a popular "myth" that once upon a time, there was an animal "Unicorn" with single horn arising from its forehead and it existed during the ancient civilizations thousands of years ago as pres..
- Sudden Unilateral Hearing Loss After non-Otologic Surgery
Abstract: A 61-year-old woman presented with sudden right-sided hearing loss with tinnitus, immediately after of laparoscopic oophorectomy. The patient is blind due to congenital retinitis pigmentosa. Physical ..
- BSN272 Prevents Western Diet-Induced Atherosclerosis and Excess Weight Gain in ApoE-/- Mice
Abstract: Objective: The purpose of this study was to determine whether BSN272 could prevent the development of hyperlipidemia and atherosclerosis in ApoE-/- knockout mice fed a Western (high fat and cholesterol, high sugar) diet. Background: BSN272 is a combination drug therapy consisting of D-tagatose and polydatin. D-tagatose..
- Honorariums: How can they be so difficult to devise?
Abstract: Honorariums (for organizing conferences and for managing journals): How can they be so difficult to devise? As only zilch comes free and nobody wants their conferences or their journals to be zilches, the society should decide and conclude to invariably pay their organizers and their editors unless the society keeps co..
- Do We Owe Our Life Expectancy To Dental Care (or To Dentistry)? Certainly-To Some Extent
Abstract: Even in the 21st century, the United States (U.S.) health care law continues to endorse dental insurance coverage only as an option for adults and children, despite making health insurance coverage almost mandatory with provisions for penalty (fee) on the non-compliant. Our perspective’s write-up wants to make the ca..
- Predictive value of procalcitonin in respiratory adenovirus infections in children with elevated C-reactive protein levels
Abstract : Abstract: Adenoviruses (ADV) often cause respiratory infections. They have, in contrast to other respiratory viruses via a potential acute phase parameter (C-reactive protein, leukocytes and interleukin 6) to trigger. ADV infections are associated with increased secretion of IL-6 and TNF-?lpha, which activates the ..
- Does the Decision-to-incision Time Affect Neonatal Outcomes in the Emergency Cesarean Section?
Abstract : OBJECTIVES We examined whether the decision-to-incision (D-I) interval of 30 min in women undergoing emergency C-section is meaningful for actual clinical outcomes of neonates. We also examined the co..
- 4-Week Toxicity and Toxicokinetic Oral Gavage Study with Polydatin in Rats
Abstract: Objective: This study determined the toxicity and toxicokinetics of polydatin when administered via oral gavage to Sprague Dawley rats daily for 4 weeks. Background: Polydatin continues to be investig..
- Effect of BSN272 on Hyperlipidemia and Atherosclerosis in LDLr-/- Mice
Abstract : This study was designed to compare the effects of D-tagatose with BSN272 on serum lipids and prevention of atherosclerosis in LDLr-/- mice. BSN272 is a combination drug of D-tagatose and polydatin (tr..
- Etiology of Non-Syndromic Facial Asymmetry: experimental study
Abstract: The identification of skeletal problems in a growing patient need a carefully treatment planning. Skeletal asymmetry in a growing patient should be treated in a conservative way, unlike the same dismorphosis in a patient that have completed his growth therapy is exclusively surgical. The etiopathogenesis of facial asym..
- Influence of occlusal features and orthodontic treatment on temporomandibular disorders: a systematic review
Abstract : Temporomandibular disorder (TMD) is a common diseases of the craniofacial region characterized by functional disturbances of the masticatory system. The etiology of TMJ is multifactorial, involving a large number of direct and indirect etiological factors, with occlusion playing only a minor part (only 10-20%), without..
- Treatment Options in Pseudo-Third Class Malocclusions: a Systematic Review
Abstract : The third Class malocclusion1 is fortunately a non frequent skeletal malocclusion, infant in europe is reported with an occurrence of 1-4% in Caucasian population2, meanwhile there is an highest percentage in italian’s population3. However, we need to distinguished the real third class from the so-called “pseudo-th..
- Comparison Between 3d and 2d Images in Diagnosis and Treatment of Facial Asymmetries: a Systematic Review
Abstract : PA cephalogram has been used in orthodontic for the treatment of asymmetry1,2. The PA cephalogram provides information useful for facial asymmetric evaluation and for evaluation of the craniofacial skeleton and dentoalveolar structures in frontal plane3. We know how PA cephalogram is a projection of a three-dimensional..
- Comparison of Frankel Regulator and Cervera Appliance in Functional Treatment of Class II Malocclusions: A Systematic Review
Abstract : Background: The Class II Malocclusion is the most frequent dento-skeletal anomaly that involves one third of all orthodontic patients. So many appliances have been described in the literature for treating this malocclusion, in particular when it’s indicated to obtain a mandibular advancement. The aim of this study is..
- Van der woude syndrome. Cardinal signs, epidemiology, associated features, differential diagnosis and treatment: a review
Abstract : The Van der Woude syndrome (VWS), is a rare autosomal dominant disease due to a genetic mutation. The cardinal sign of this syndrome are labial fistulas. It is often associated with cleft lip, labial and palate. Cleft lip in 66.2% of cases, labial in 16,5% of cases and palatal in 17.3% of cases. The treatment of fistul..
- "Not Hesitate, Use Etomidate: Use Etomidate, Not Hesitate!" Alternates Opine, "Whyn't Ketamine!"
Abstract: The human population is NEITHER getting smaller in terms of weight gain trends NOR healthier in terms of cardiovascular health trends. Irrespective of fluctuating time-trends in regards to cardiovascular mortality, cardiovascular diseases' societal burden related to cardiovascular morbidity may be increasing overall, r..
- Does Naloxone Infusion Improve Recovery from Delirium in Intensive Care Unit? A Worth Exploring Project Into An Uncharted Domain
Abstract: Hypoactive delirium is difficult to differentiate from over-sedation and is often treated as such. However, hyperactive delirium with its agitation component is easily identified and differentiated by the Intensive Care Unit (ICU) personnel. This type of delirium irrespective of its underlying etiologies or risk factor..
- A New Nominal Scale (Yes-No-Don't Know-YNDK Scale) and Its Correlation with Standard Ordinal Scale (Numerical Rating Scale-NRS): Our Experience Among University Based Pain Clinic Patients
Abstract: Background: There are variety of pain scales available for use by the health care providers to assess patients' pain. Numerical rating scales (11-point 0-10 NRS) are one of the most commonly used pain..
- Evaluation of techniques used for disimpaction and uprighting of mandibular second molars: a systematic review
Abstract : The second molars developed, like all the other teeth, by the dental lamina which starts to form at the level of stomodeo between the VI and VII weeks of intrauterine life. These teeth, and in particular second mandibular molars may develop some eruptive path alterations that determine their impaction or inclusion agai..
- Treatment options for Class III Malocclusions in growing patients: A Systematic Review
Abstract : The class III malocclusion is defined when the lower first molar is more mesial than the upper first molar and it can be determinated by maxillary retrusion, mandibular protrusion, or both. The etiology is multifactorial, and it seems to be involved environmental and genetic factors. Indeed, class III malocclusion is t..
- Twin Block, Bionator and Frankel II: comparative study
Abstract : Many appliances are described in the literature in the second molars class where you want to obtain a mandibular advancement . The aims of this study is to compared, with a literature review using PubMed from 1998 to 2016, dental and skeletal effects of Twin Block, the Bionator and Frankel II. The final results fo..
- Use of TADs in Treatment of Class II Malocclusion: An overview
Abstract : The treatment of class II malocclusion during adolescence is an important challenge for orthodontists, moreover, if there are other growth factors that hinder the reaching of a normal occlusion. Maxillary molar distalization is an orthodontic treatment method that has obtained an important diffusion since last years fo..
- Treatment modalities for Anterior Open Bite: a Systematic Review
Abstract : Anterior open bite (AOB) is a very common malocclusion in the orthodontic practice. The management of this malocclusion is not easy because of its multifactorial etiology; indeed, there are many factors which determines its etiology: oral habits, alterated labial postures, tongue habits and a vertical facial growth pat..
- A short note on comparative analysis of acetylcholinesterase genes in mosquito genome
Abstract: Acetylcholineserase genes confer the organophosphate and carbamate resistance mechanism. A total of 46 acetylcholineserase genes in the 24 mosquito genomes were identified. In this study, all the anal..
- Dental Agenesis and Malocclusion: A Systematic Review
Abstract : The dental agenesis is a congenital disease that gives rise to the absence of one or more teeth and this can affect the deciduous dentition as the permanent too. This alteration is the result of a disorder of the dental lamina during the training process. These patients need a multidisciplinary treatment by the orthodo..
- Comparison of Twin Block and Herbst Appliances in Treatment of Class II Malocclusion: a Systematic Review
Abstract : In growing patients, it is possible to correct a second class skeletal mandibular retrusion with functional orthodontic appliances. We have viewed 1982-2016 PubMed articles to compare, in terms of compliance, timing, dental effects, and skeletal profilometric changes Twin block and Herbst appliances. The dental and ske..
- Comparison between Nolla and Demirjian dental age assessment methods: a Systematic Review
Abstract : Background: Estimation of age has great importance in clinical practice, not only in orthodontics, being commonly used forensic medicine, radiology and paediatrics. For this reason, the Nolla and Demirjian methods have been developed. Several studies have been performed to determine the chronological age analysing the ..
- The place of US for the diagnosis of clinically suspected abdominal bleeding in trauma patients
Abstract: Purpose: We present our experience in the diagnosis,follow-up and planning therapy of free abdominal collections in trauma patients using conventional and interventional ultrasound. Methods and Materi..
- Comparison of Orthodontic Techniques used for treating patients with severe form of scissor bite: a systematic review
Abstract : Background: Severe forms of scissor bite or Brodie syndrome is rare orthodontic malocclusion that occurs with a frequency of 0.01% in general population. Several methods have been described to obtain a correction from a dental, skeletal and soft tissutal points of view. In literature it was described: jaws osteotomies,..
- Toward Surreptitious Remote Sensing of Blood Alcohol Concentration: Results with Integrated Near-Infrared Spectral Imaging and Laser Speech Detection
Abstract: Alcohol abuse is a major problem in the United States. The most common measurement tool used in law enforcement for the determination of alcohol concentration in subjects is the breath analyzer (BrAC)..
- Mythology may NOT be Just A Myth: Theoretical Biology may NOT be Just A Theory: Connecting The Dots: Was "Sanjeevani" Naloxone?
Abstract: Steve Jobs, the co-founder of Apple Inc., once spoke that the connection among the past-dots happens in the present times, that explore the past in the retrospect. Henceforth, in the below-mentioned and elaborated text, the focus is on the possibility to explore the science underplayed when "Sanjeevani" (the reviver) w..
- "Paid" Medical Research For Students: Time For Minimum-Wage Medical Research Internships
Abstract: As a researcher myself, I have always wondered about what drives the pursuit of research. There is data to suggest the positive impact of medical student research for future evolution as academic physicians or physician-scientists. The data from undergraduate student research, however, suggests that pre-medical student..
- Connecting The Dots in Theoretical Anthropology: Was This One of The Earliest Contemplation About Homo sapiens sapiens' Fight for Survival and Interactions with Homo sapiens neanderthalensis and Homo sapiens denisova?
Abstract: Watching the documentary, "Ape to Man" (2005), make us wonder, whether the major plot in the Hindu mythological epic, "Ramayan", was one of the earliest contemplation about the fight for survival between the two evolving sub-species of human beings (anatomically modern humans and Neanderthals) and the coexistence of ap..
- Human Immuno-Deficiency Virus Drug Resistance, Nuclesoide Reverse Transcriptase Inhibitors, Non-nuclesoide Reverse Transcriptase Inhibitors and associated drug resistance mutations in the Reverse Transcriptase Gene of Human Immuno Deficiency Virus-1.
Abstract : Resistance develops due to mutations in the reverse transcriptase gene of HIV-1 genome that does not respond towards the presence of effective drugs. Emergence of HIV-1 variants in the presence of effective drugs is a common occurrence. Drug resistance mutation means “the development of resistance mutations in the dr..
- Active lingual retainer - A Case series
Introduction: Removable retainers are appliances used extensively to preserve stability and prevent relapse following orthodontic treatment. The magnitude of their importance as a part of routine retention procedur..
- Effectiveness of oil masage on weight gain among pre-term neonates in selected pediatric hospitals, Hyderabad
Abstract: Improved technology and treatment modalities have enhanced the outcomes of pre-term infants yet have increased the days they spend in the Neonatal Intensive Care Unit, thus are subjected to a highly s..
- Polymerase chain reaction in exploring endodontic infections
Abstract: Traditionally cultivation, microscopic and immunological based techniques were only the means by which endodontic microbiota were studied. Because of their several limitations in microbiological diagnosis, newer molecular genetic methods were introduced. Polymerase chain reaction -PCR is a widely spread advance in clin..
- Great Responsibility with Exposing Human Emotion: Explore Futuristic Automated Face Reading
Perspective: For the sake of its incorporation into clinical diagnosis and management when practicing medicine, Ragsdale et al [1] studied human emotions based on under-appreciated explicitness in the subtleties of human face, a phenomenon recently popularized by Dr. Paul Ekman. I have been interested in Dr. Ekman's courses [2] sin..
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