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Reviews
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Other Comments:
The author's rationale is reliable and sound.
Key antioxidants to neutralize ROS are covered in detail.
Exercise and age may tax the mitochondria life span and raise ROS levels, with modest exercise rebound mechanisms reducing ROS post-exercise.
The author presents an excellent idea for reducing the degenerative processes observed in diabetic neuropathy. Reduced Ubiquinone may be a treatment protocol that larger studies conducted to may determine favorable effects and dose.
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Competing interests:
None
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Invited by the author to review this article? :
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Have you previously published on this or a similar topic?:
Yes
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References:
Misner B., Does Glutathione Enhance Exercise Performance? - A Case Study. The Townsend Letter For Doctors & Patients. July 2003:66. http://www.townsendletter.com/ Misner B . Coenzyme Q-10 Effects Endurance Runner's Performance - A Case Report . WebmedCentral ALTERNATIVE MEDICINE 2011;2(11):WMC002437 http://www.webmedcentral.com/article_view/2437 -
Experience and credentials in the specific area of science:
Misner B . Coenzyme Q-10 Effects Endurance Runner's Performance - A Case Report . WebmedCentral ALTERNATIVE MEDICINE 2011;2(11):WMC002437 http://www.webmedcentral.com/article_view/2437
- How to cite: Misner B .Diabetic Neuropathy Mitochndria Required Antioxidant-Need for Coenzyme Q10[Review of the article 'Diabetic Neuropathy And The Mitochondria,Can Coenzyme Q Be Of Help ' by Arora P].WebmedCentral 2011;2(11):WMCRW001118
- Other Comments: The manuscript is easy to follow and it is well written. It is interesting and of general interest.
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
One Year - How to cite: Sharma J .Diabetic neuropathy and the mitochondria: Can Coenzume Q be of help?[Review of the article 'Diabetic Neuropathy And The Mitochondria,Can Coenzyme Q Be Of Help ' by Arora P].WebmedCentral 2011;1(10):WMCRW0052
The authors propose that the anti-oxidant properties of Coenzyme Q may help diabetic neuropathy by reducing oxidative stress.
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The paper gives a plausible hypothesis regarding the treatment of diabetic neuropathy using the anti-oxidant properties of Coenzyme Q.
There are some grammatical concerns, but none the less the authors provide an interesting review on the literature. It's certainly plausible that ongoing mitochondrial oxidative stress may contribute to lipid peroxidation, etc. and cellular breakdown. The idea is also supported by the literature regarding the benefint of alpha-lipoic acid (please see: A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol. 2012 Oct;167(4):465-71). This area certainly needs more research. What is the dose and frequency that shoud be used? Should we be giving our patient anti-oxidant cocktails, with Coenzyme Q being only one component? Of note, the Parkinson's disease literature regarding the role of Coenzyme Q in mitochondral health and improves outcome is encouraging (please see: Cochrane Database Syst Rev. 2012 May 16;5:CD008150), but more studies on both fronts are needed before any conclusive recommendations can be made.
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General neurology