Dr.Herchline: "This is a trial with N=1, a single subject. No conclusions can be made from the data presented."
Dr.Misner: The final statement in the Abstract substantially limited this case study results to one subject male 71-years calling for more research with substantial numbers to confirm or deny the trend identified...Abstract final sentence declared: "For these results for one subject male 71-years to be conclusive the trend should further confirmed or denied by examining dose and performances associated from a larger contingent of male and female runners over age 40."
Dr. Herchline: "There are references within the body of the article, but no section at the end of the paper for listed references."
Dr. Misner: You are correct, thank you. The references were pasted in originally; I have contacted WebMedCentral to correct this omission.(a copy of the orignal copy references is listed below)


References
1.Badmaev V, Majeed M, Norkus E, Piperine, an alkaloid derived from black pepper increases serum response of beta carotene during 14 days of oral beta carotene supplementation. Nutr. Res. (1999) 19(3): 381-388.
2.Badmaev V, Majeed M, Prakash L, Piperine derived from black pepper increases the plasma levels of coenzyme q10 following oral supplementation. J Nutr Biochem. 2000 Feb 1;11(2):109-113.
3.Barbiroli, B., et al.  Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy.  Cell Mol Biol.  43(5):741-749, 1997.
4.Bargossi, A. M., et al.  Antioxidant effects of exogenous ubiquinone (Q10) in high level endurance runners.  Free Radicals and Antioxidants in Nutrition.  1993:63-74.
5.Bonetti A, Solito F, Carmosino G, Bargossi AM, Fiorella PL. Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects. J Sports Med Phys Fitness. 2000 Mar;40(1):51-7.
6.Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 2008 Mar 4;5:8.
7.Cornell University Age Calculator @: http://www-users.med.cornell.edu/~spon/picu/calc/agecalc.htm
8.Dhanasekaran M, & Ren J, The Emerging Role of Coenzyme Q10 in Aging, Neurodegeneration, Cardiovascular Disease, Cancer and Diabetes Mellitus, Current Neurovascular Research, 2(5): 447- 59, December 2005.
9.Ernster L, Dallner G: Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta, 1995; 1271: 195-204.
10.Gaby, Alan R, MD, Coenzyme Q10 - Textbook of Natural Medicine, NY: Churchill Livingstone, pp 663-71, 1999.
11.Gökbel H, Gül I, Belviranl M, Okudan N. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res. 2010 Jan;24(1):97-102.
12.Lenaz, G., et al.  Oxidative stress, antioxidant defenses and aging.  Biofactors.  8:195-204, 1998.
13.Papucci, L., et al.  Coenzyme Q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical-scavenging property.  J Biol Chem.  20
14.Quinzii CM, DiMauro S, Hirano M. Human coenzyme Q10 deficiency. Neurochem Res. 2007 Apr-May;32(4-5):723-7. Epub 2006 Nov 10.Review.
15.Rosenfeldt FL, Pepe S, Ou R, Mariani JA, Rowland MA, Nagley P, Linnane AW. Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue. Biofactors. 1999;9(2-4):291-9.
16.World Association of Veteran Athletes (WAVA) Age-grading calculator 2006 (updated 2010) @: http://www.howardgrubb.co.uk/athletics/wmalookup06.html
Dr. Bill Misner requests Dr. Herchline repeat his review in light of this respectfully-intended correction.

• competing interests: None
• Invited by the author to make a review on this article? :
• Experience and credentials in the specific area of science:

  Misner B., & Cranton E., Endurance Performance Gains Following Intravenous EDTA Chelation Therapy In A Healthy 60-year Old Athlete. CLINICAL PRACTICE OF ALTERNATIVE MEDICINE, Volume 2, Number 2, Summer 2001: Pages 135 & 136. http://www.acam.org/summer_2001.php
  
  Bagchi D, Misner B, Bagchi M, Kothari SC, Downs BW, Fafard RD, Preuss HG.  Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10. PMID: 12837047 [PubMed - indexed for MEDLINE]
  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12837047&dopt=Abstract
  
  Misner, B.  Food alone may not provide sufficient micronutrients for preventing deficiency.  Journal of the International Society of Sports Nutrition.  3(1):51-55, 2006. http://www.sportsnutritionsociety.org/site/journal/abstract.php?article_id=59
  
  Misner B. A Novel Device Reduces Spoilage from Aerobic Bacterial Growth in Refrigerated Apples
  Townsend Letter for Doctors & Patients October 2005 #267; page 71. http://www.townsendletter.com/Oct2005/noveldevice1005.htm
  
  Misner B., Does Glutathione Enhance Exercise Performance? - A Case Study. The Townsend Letter For Doctors & Patients. July 2003:66. http://www.townsendletter.com/
  
  Misner B. "Does the Growth Rate of Aerobic Bacterial Cells in Organic Plant Foods Reflect the Health Potential of that Food in Human Cells?" Townsend Letter for Doctors & Patients - The Examiner Of Medical Alternatives. August/September 2004: 78-80. http://www.townsendletter.com/
  
  Misner Bill. Fifty Nutrient Associations That Influence Health State, TOWNSEND LETTER, http://www.townsendletter.com/Jan2008/50assn0108.htm
  
  Misner Bill. Novel Oral Compound May Inhibit Upper-Respiratory Infection, Townsend Letter October 2009. http://www.townsendletter.com/Oct2009/Oct2009.html
  
  Misner Bill. "Is Milk Associated with Obesity?" The Townsend Letter for Doctors and Patients. May 2010. http://www.townsendletter.com/

   

  Bill Misner experience in running competitions  1989-2011

  2011 USA National 50K Trail National Champion - ages 70-up.
  2011 USA National 15K Trail National Champion - ages 70-up.
  2011 USA National Half Marathon Trail Champion - ages 70-up.
  2010 USA National 15K Trail Championship Runnerup ages 70-up.
  2008-2011 Twelve-Time All American Honors - Competitive Running - 5K to Half Marathon Runs, USA National Masters News
  2007 PBAA Top 15 Perimeter Cyclists - All Time World Ranking 13th
  2006 PBAA Top 15 Perimeter Cyclists - All Time World Ranking 14th
  2005 PBAA Top 20 Perimeter Cyclists - All Time World Ranking 16th
  2002-2004 PBAA Most Mountain Perimeter Cycling World Records (18)
  1998 - Two World Records (1) 10,000 miles (2) 20,000 kilometers c in the "Million Mile Ultra."
   (First person in recorded history to run 10,000 miles and 20,000 kilometers in an organized running event.)
  1998 - Who's Who in Running, Runners Hall of Fame 
   http://www.runtheplanet.com/resources/historical/whoswhoinrunning.asp
  1992 - USA Masters National Champion 4 X 800 meters USA TF Track and Field
  1991 - USA Masters 50-mile National Champion ages 50+
  1991 - USA Masters 12-hour National Record Masters age group 50-54
  1990 - USA Masters 24-hour runner-up National Championships (21st Place USA)   
  1989 - USA Masters 50-mile National Champion ages 40+
  1985 - USA 20-mile National Record Masters age group 45-50

• Publications in the same or a related area of science: No
  
• References: None

Dr. Misner's response to Dr. Shenkman's review comments 1, 2, 3:

Dr. Shenkman: 1-"The data presented do not support the conclusions."
Dr. Misner: The last sentences in both the Abstract and Competing Interest paragraphs clearly associate these performance results with the single subject only. Abstract: "For these results for one subject male 71-years to be conclusive the trend should further confirmed or denied by examining dose and performances associated from a larger contingent of male and female runners over age 40." Competing Interests: "No competing interests declared, the author was the single subject of this case study, therefore the results are associated with his performance only. This case study calls for more measures collected from other subjects, male and female ages 40-and-over to confirm or deny the trend this single-subject case study discusses."

Dr. Shenkman: 2-"It would have been useful to see the actual times for each run in each of the three categories. Running times should have been presented as the mean and SD of each category, and not as the best time in each category."
Dr. Misner: Table I shows the best times recorded in two each 90-day test-dose periods. This table lists the times and dates and the exact age of the test subject the day they were recorded. Performance optimums are difficult to predict but it is the opinion of many sport scientists that performance peaks can be attained after 90-day training period within 12-14 weeks by testing performance trials when resting heart rate reaches lowest point confirming recovery from training stress. This is why during the Ubiquinol period, 12-timed trials were collected but during the Ubiquinone period (the second 90-day period), only 8-timed performance trials were collected. The differences between mean timed performances and SD's were similar and may not add information to the results reported.

Dr. Shenkman: "The structure of a standard paper contains the Discussion at the end, not prior to Methods and Results."
Dr. Misner: Most, not all, journal-style scientific papers are subdivided into: Title, Authors and Affiliation, Abstract, Introduction, Methods, Results, Discussion, Acknowledgments, and Literature Cited, which parallel the experimental process. Moving the Discussion section to precede the Methods, Results sections presents information that explains information paramount to Methods and Results sections.

Addendum: I read Dr. Shenkman's research years ago "Serum enzyme activities following long-distance running: comparison between Ethiopian and white athletes.." I am pleased to have his esteemed review of my paper.
Bill Misner

• competing interests: None
• Invited by the author to make a review on this article? :
• Experience and credentials in the specific area of science:

  Author: Dr. Bill Misner, Ph.D.
  
  AAMA Board Certified Alternative Medicine Practitioner Certification #32872409

• Publications in the same or a related area of science: Yes
  
• References: None

i must say that it is a well written and single case study as mentioned in the competing Interests sections so it is not for general study population. i strongly appreciate author efforts.      

• Invited by the author to make a review on this article? :
• Experience and credentials in the specific area of science: None
• Publications in the same or a related area of science: No
  
• References: None