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Dr. Krishnan Manickam

Research Scientist
Pathology- The University of Texas Health Science Center
7703 Floyd Curl Drive, San Antonio, Texas USA

Brief Biography:

Dr. Krishnan Manickam received his M.S. and Ph.D. in Environmental Toxicology from University of Madras Chennai, India. After his Ph.D. program, he worked as an Assistant Professor and Assistant Research officer at Sri Ramachandra University, Chennai, India. He carried out his postdoctoral research at Stanford University CA USA and also at The University of Texas Health Science Center at San Antonio, Texas USA. He is currently employed at The University of Texas Health Science Center at San Antonio, Texas USA as a Research Scientist in Pathology.


Academic positions:

Research Scientist (2014-Present): The University of Texas Health Science Center at San Antonio, Texas. Postdoctoral fellow (2006-2012): The University of Texas Health Science Center at San Antonio, Texas Postdoctoral fellow (2004-2006): Stanford University CA USA Assistant Professor and Assistant Research officer (2001-2004): Sri Ramachandra University, Chennai, India


Research interests:

I am a research investigator for 18 years in the field of molecular cell biology, molecular imaging, cancer genetics (genetic epidemiology). My research expertise are on protein-protein interaction, cell signaling, cellular protein trafficking, non-invasive in-vivo imaging of living subjects and cellular pathway analysis relevant to cancer. My current studies on a sustained amplification of NF-kB-TNF-α positive feedback loop has any influence on stimulation of predisposing factors for radiation-induced carcinogenesis and potentiates pro-tumorigenic cells to pre-malignant phenotype. This study is also showing how TNF-α involves in the generation of oxygen free radicals that could cause persistent genetic damages. This genetic impairment could escape from the DNA repair mechanism and it contributes the genomic instability that leads to carcinogenesis in human primary cells and also in various cancer cells.  Another my study on the impairment of eNOS activity and deficient interaction between eNOSàIKKβàHsp90 functions in the human vascular system that leads to cardio-vascular complications in the human health. A portion of these are the studies have been published recently. I am a one of the key research study personnel to peruse on these studies in the current research projects by take up to the next level to develop in-vivo model systems to compare with clinical applications. I have also been performing several collaborative researches on cardio-vascular complication due to radiation. My current research is also on environmental and space radiation that potentiates pro-tumorigenic to pre-malignant cancer phenotype.


What I think of the idea behind WebmedCentral:

It is an innovative idea to provide potential opportunities to the biomedical researcher to share and publish their original scientific research work quickly.


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