Dr. Shabir Qureshi

Brief Biography:

Qureshi SH., Yang L, Rezaie AR. Contribution of the NH2-terminal EGF-domain of factor IXa to the specificity of intrinsic tenase. Thromb Haemost. 2012 Sep 26;108(6): 1154-64. Yang L, Manithody C, Qureshi SH., Rezaie AR. Role of the residues of the 39-loop in determining the substrate and inhibitor specificity of factor IXa. J Biol Chem. 2010, 285(37):28488-95. Manithody C, Qureshi SH,, Rezaie AR. Inhibitory properties of the P1 Tyr variant of antithrombin. Biochemistry. 2010, 49(12); 2680-6. Yang L, Manithody C,, Qureshi SH., Rezaie AR Contribution of exosite occupancy by heparin to the regulation of coagulation protease by antithrombin. Thromb Haemost. 2010. 103(2) 277-83. Yang L, Qureshi SH., Manithody C, Rezaie AR. Role of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases. Biochem Biophys Res Commun. 2009, 389(1); 162-7. Qureshi SH., Yang L, Manithody C, Iakhiaev AV, Rezaie AR. Mutagenesis Studies toward Understanding Allostery in Thrombin. Biochemistry. 2009, 48(34); 8261-70. Qureshi SH., Yang L, Manithody C, Rezaie AR. Membrane-Dependent Interaction of Factor Xa and Prothrombin with Factor Va in the Prothrombinase Complex. Biochemistry. 2009, 48 (22); 5034-41. Xie F, Qureshi SH., Papadakos GA, Dupureur CM. One- and two-metal ion catalysis: global single-turnover kinetic analysis of the PvuII endonuclease mechanism. Biochemistry. 2008, 47(47); 12540-50. Rezaie AR, Bae JS, Manithody C, Qureshi SH., Yang L. Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z. J. Biol Chem. 2008, 283(29); 19922-6. Yang L, Manithody C, Qureshi SH., Rezaie AR. Factor Va alters the conformation of the Na+-binding loop of factor Xa in the prothrombinase complex. Biochemistry. 2008, 47(22); 5976-85. Qureshi SH., Yang L, Manithody C, Bae JS, Rezaie AR. Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C. Biochim Biophys Acta. 2008, 1780(9); 1080-6. Qureshi SH., Manithody C, Bae JS, Yang L, Rezaie AR ) Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays. Biophys Chem. 2008, 134(3); 239-45. Qureshi SH, Yang L, Yegneswaran S, Rezaie A.R. FRET studies with factor X mutants provide insight into the topography of the membrane-bound factor X/Xa.Biochem J. 2007, 407; 427-33. Moza, B., Qureshi, SH., Islam, A., Singh, R.K., Anjum, F., Movahedi, A.A.M., Ahmad, F. A Unique Molten Globule State Occurs during Unfolding of Cytochrome-c by LiClO4 Near Physiological pH and Temperature: STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION . Biochemistry. 2006, 45; 4695-4702. Moza, B., Qureshi, SH., and Ahmad, F. Equilibrium Studies of the Effect of Difference in Sequence Homology on the Mechanism of Denaturation of Bovine and Horse Cytochromes-c. Biochimica et Biophysica Acta. 2003, 1646; 49-56. Qureshi, SH., Moza, B., Yadav, S., Ahmad, F. Conformational and Thermodynamic Characterization of the Molten Globule State Occurring During Unfolding of Cytochromes-c Using Weak Salt Denaturants. Biochemistry. 2003, 42; 1684-1695. P Dinarvand , Hassanian SM., Qureshi SH., Manithody C, Eissenberg JC., Yang L and Rezaie AR. Polyphosphate amplifies proinflammatory responses of nuclear proteins through interaction with receptor for advanced glycation end products and P2Y1 purinergic receptor. Blood 2013 (In Press)

Academic positions:

Positions and Employment

1. 7/2006 – Present: Postdoctoral Research Scientist, Saint Louis University School of
Medicine, Dept. of Biochemistry and Molecular Biology
2. 4/2004 – 6/2006: Visiting Fellow, University of Missouri, St.Louis Dept. of
Chemistry and Biochemistry
3. 09/2003 to 3/2004: Research Associate, Protein Research Lab, Department of
Biosciences, Jamia Millia Islamia, New Delhi, India.
4. 06/2000 to 9/2003: Senior Research Fellows, (CSIR, N. Delhi) Department of Biosciences,
Jamia. Millia Islamia, New Delhi, India.
5. 6/1998 to 05/2000: Junior Research Fellow, (CSIR, N. Delhi) Department of Biosciences,
Jamia Millia Islamia, New Delhi, India.

Awards/Fellowships

1. National Eligibility Test (NET) in 2001 conducted jointly by CSIR and UGC, New Delhi India. A national test conducted for eligibility for research fellows and assistant professors in Universities and research institutes in India.
2. State Level Eligibility Test (SLET) in 2000 conducted by Jammu University, Jammu. A national test conducted for eligibility for assistant professors and lecturer in Indian Universities and higher education institutes.
3. National Eligibility Test (NET) in 1998 conducted by Agriculture Scientist Research Board (ASRB) Indian Council for Agriculture Research New Delhi. A national test conducted for eligibility for scientists and research fellows in Indian Universities.
4. Graduate Aptitude Test for Engineering (GATE) in 1998 conducted jointly by IIT Delhi and UGC. A national test that primarily tests the comprehensive understanding of various undergraduate subjects in engineering and science.

Research interests:

Structure function relation, Biophysics, Fluorescence and luminescence, Enzymology.

Any other information:

Publications

1. P. Dinarvand , Hassanian SM., Qureshi SH., Manithody C, Eissenberg JC., Yang L and Rezaie AR. Polyphosphate amplifies proinflammatory responses of nuclear proteins through interaction with receptor for advanced glycation end products and P2Y1 purinergic receptor. Blood. 2013 Nov 19. [In press]
2. Qureshi SH., Yang L, Rezaie AR. Contribution of the NH2-terminal EGF-domain of factor IXa to the specificity of intrinsic tenase. Thromb Haemost. 2012 Sep 26;108(6): 1154-64.
3. Yang L, Manithody C, Qureshi SH., Rezaie AR. Role of the residues of the 39-loop in
determining the substrate and inhibitor specificity of factor IXa. J Biol Chem. 2010,
285(37):28488-95.
4. Manithody C, Qureshi SH,, Rezaie AR. Inhibitory properties of the P1 Tyr variant of antithrombin. Biochemistry. 2010, 49(12); 2680-6.
5. Yang L, Manithody C,, Qureshi SH., Rezaie AR Contribution of exosite occupancy by heparin to the regulation of coagulation protease by antithrombin. Thromb Haemost.
2010. 103(2) 277-83.
6. Yang L, Qureshi SH., Manithody C, Rezaie AR. Role of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases. Biochem Biophys Res
Commun. 2009, 389(1); 162-7.
7. Qureshi SH., Yang L, Manithody C, Iakhiaev AV, Rezaie AR. Mutagenesis Studies toward Understanding Allostery in Thrombin. Biochemistry. 2009, 48(34); 8261-70.
8. Qureshi SH., Yang L, Manithody C, Rezaie AR. Membrane-Dependent Interaction of Factor Xa and Prothrombin with Factor Va in the Prothrombinase Complex. Biochemistry. 2009, 48 (22); 5034-41.
9. Xie F, Qureshi SH., Papadakos GA, Dupureur CM. One- and two-metal ion catalysis: global single-turnover kinetic analysis of the PvuII endonuclease mechanism. Biochemistry. 2008, 47(47); 12540-50.
10. Rezaie AR, Bae JS, Manithody C, Qureshi SH., Yang L. Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z. J. Biol Chem. 2008,
283(29); 19922-6.
11. Yang L, Manithody C, Qureshi SH., Rezaie AR. Factor Va alters the conformation of
the Na+-binding loop of factor Xa in the prothrombinase complex. Biochemistry. 2008,
47(22); 5976-85.
12. Qureshi SH., Yang L, Manithody C, Bae JS, Rezaie AR. Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C. Biochim Biophys Acta. 2008, 1780(9); 1080-6.
13. Qureshi SH., Manithody C, Bae JS, Yang L, Rezaie AR. Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays. Biophys Chem. 2008, 134(3); 239-45.
14. Qureshi SH, Yang L, Yegneswaran S, Rezaie A.R. FRET studies with factor X mutants
provide insight into the topography of the membrane-bound factor X/Xa. Biochem J.
2007, 407; 427-33.
15. Moza, B., Qureshi, SH., Islam, A., Singh, R.K., Anjum, F., Movahedi, A.A.M., Ahmad,
F. A Unique Molten Globule State Occurs during Unfolding of Cytochrome-c by LiClO4 Near Physiological pH and Temperature: STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION. Biochemistry. 2006, 45; 4695-4702.
16. Qureshi, SH., Moza, B. and Ahmad, F. Equilibrium Studies of the Effect of Difference in Sequence Homology on the Mechanism of Denaturation of Bovine and Horse Cytochromes-c. Biochimica et Biophysica Acta. 2003, 1646; 49-56.
17. Qureshi, SH., Moza, B., Yadav, S., Ahmad, F. Conformational and Thermodynamic Characterization of the Molten Globule State Occurring During Unfolding of Cytochromes-c Using Weak Salt Denaturants. Biochemistry. 2003, 42; 1684-1695.
18. Yang L, P. Dinarvand, Qureshi SH., Rezaie A.R. Engineering D-Helix of Antithrombin in Alpha-1-proteinase Inhibitor Confers Anti-inflammatory Properties on the Chimeric Serpin. Thromb. Haemost. (Under revision).

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