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Dr. Holly Holman

Adj Professor
Bioengineering, University of Utah

Brief Biography:

EDUCATION Institution Degree Dates Area of Research MRC Institute of Virology Ph.D. 2000 Neuro-Virology University of Glasgow (UK) Lyman Briggs College, B.S. 1996 Biology and Michigan State University Microbiology PUBLICATIONS 1. Holman, H.A., Nguyen, L., Tran, V.M., Sailaja Arungundram, S., Balagurunathan Kuberan, B., Rabbitt, R.D. BODIPY conjugated Xylosides Reveal Repair and Regeneration of the Semicircular Canal Cupula. Manuscript in Preparation. 2. Koshiba, T., Holman, H.A., Yasukawa, K, Kubara, K., Kawabata, S. Okamoto, K. and Shaw, J.M. (2011) Functional roles from both GTPase and EF-hand domains of Gem1p, a yeast Miro GTPase, are essential for mitochondrial inheritance. J Cell Bio. 286(1):354-62. PMID: 21036903 3. Holman, H.A. and A.R. MacLean. (2008) Neurovirulent factor ICP34.5 uniquely expressed in the HSV-1 delta-gamma-1-34.5 mutant 1716. J Neurovirol. 14(1); 28-40. PMID: 18300073 4. Sarmiento, C. H., W. Wang, A. Dovas, H. Yamaguchi, M. El-Sibai, V. Desmarias, H.A. Holman, S. Kitchen, J.M. Backer, A. Alberts, and J. Condeelis. (2008) The role of WASP family members and formins in actin reorganization in cell protrusions. J Cell Bio. 180(6);1245-60. PMID: 18362183 5. Eisenmann, K.M., E.S. Harris, S.M. Kitchen, H.A. Holman, H.N. Higgs, and A.S. Alberts. (2007) Dia-Interacting Protein Modulates Formin-Mediated Actin Assembly at the cell cortex. Curr Biol 17(7):579-91. PMID: 17398099 6. Wallar, B.J., Stropich, B.N., Schoenherr, J.A., Holman, H.A., Kitchen, S.M., and Alberts, A.S. (2006) The basic region of the diaphanous-autoregulatory domain (DAD) is required for autoregulatory interactions with the diaphanous-related formin inhibitory domain. J. Biol. Chem. 281(7):4300-4307. PMID: 16361707 7. Cook, W.J., M.F. Kramer, R.M. Walker, T.J. Burell, H.A. Holman, D.M. Coen, and D.M. Knipe (2004) Persistent Expression of Chemokine and Chemokine Receptor RNAs at Primary and Latent Sites of Herpes Simplex Virus 1 Infection. Virol J 1:5. PMID: 15507126 8. Kramer, M.F., W.J. Cook, F.P. Roth, J. Zhu, H. Holman, D.M. Knipe, and D.M. Coen (2003) Latent Herpes Simplex Virus Infection of Sensory Neurons Alters Neuronal Gene Expression. Journal of Virology 77(17); 9533-9541. PMID: 12915567 9. Holman, H.A. and A.R. MacLean. Herpes simplex virus type 2 expresses the neurotropic protein ICP34.5 from gamma(1)34.5 and the presence of an intron leads to expression of a second polypeptide. Poster Presentation at the Herpes International Workshop. (double major)


Academic positions:

2010-present Two projects; 1. Studying mitochondrial, calcium and temperature effects of pulsed infrared radiation and near infrared in HeLa cells. 2. Studying click-xylosides in the generation of glycosaminoglycans, repair and cell regeneration of the semicircular canal cupula. 2007-2010 Using yeast genetics, biochemistry and fluorescence microscopy to research pathways of mitochondrial inheritance and transport with Prof. J. Shaw. 2004-2007 Conducted mammalian in vitro biochemical and protein structure crystallization on formin protein domains involved in mitochondrial Rho GTPase interactions with Dr. A. Alberts under the direction of Dr. George Vande Woude. 2002- 2004 Dr. M.H. Shen, Prof H Cook, and Dr. Sarah Wedden, development and commercialization of a novel method for producing fully human monoclonal antibodies. This project was awarded Scottish Enterprise Proof of Concept Funding. Edinburgh, Scotland. 2000-2002 Prof D. Knipe mentored research on murine neuroimmunology of latent herpes simplex virus. Microbiology and Molecular Genetics, Harvard Medical School and Millennium Pharmaceuticals, Cambridge, MA. 1998-1999 Thesis Research Collaboration with Dr. N. Sawtell and Prof R. Thompson in vivo methods for reactivation of latent herpes simplex virus. The Cincinnati Children’s Hospital and Dept.of Genetics, Biochem. and Micro., University of Cincinnati, Cincinnati, OH.


Research interests:

My research aspirations are three-fold. First, my primary research interests are to study the etiologies of neurodegenerative diseases. I am particularly interested in studying the conserved cell signaling molecules between the blood enteric barrier and the blood brain barrier. Second, I believe that working with veterinarians we could bridge a large knowledge gap in human neurodegenerative diseases by studying domestic dog disorders such as Balo’s Disease, Krabbe’s Disease and Canine Degenerative Myelopathies by high throughput screens. Third, I see a great need to improve upon neurological examinations for better treatments and outcomes from various neurological conditions. Using imaging technologies such as MRI and PET we have come a long way in facilitating better understandings in neurology. However, current imaging techniques are cost prohibitive, bulky and not used routinely in clinics. I am interested in developing a device that will be cost effective and quantitatively provide clinicians and their patient’s sensory and motor neuronal feedback.


Any other information:

COARSES TAUGHT BIOEN 1020 Spring 2012 “Fundamentals of Bioengineering I” (126 undergraduate students) BIOEN 6050 Fall 2011 “Cellular Physiology for Engineers” (20 graduate students) http://www.bioen.utah.edu/education/syllabi.php?op=syllabus&sylID=33 BIOEN 1102 Spring 2011 “Fundamentals of Bioengineering I” BIOEN 6050 Fall 2010 “Cellular Physiology for Engineers”


What I think of the idea behind WebmedCentral:

Open access AND peer reviews of scientific research is an amazing tool to push scientific boundaries forward.


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