Brief Biography:
Jeanette I. Webster Marketon, Ph.D. is an Assistant Professor in the Departments of Internal Medicine and Molecular and Cellular Biochemistry and an Associate Member of the Institute for Behavioral Medicine Research, The Ohio State University. Dr. Marketon received her bachelor’s degree in Biochemistry and Molecular Biology from the University of Leeds, Great Britain and her PhD from the University of Sheffield, Great Britain working in Photosynthesis Research. She completed a postdoctoral position at Stockholm University, Sweden in Photosynthesis Research before changing to the field of Nuclear Receptors during a postdoctoral position at the Karolinska Institutet, Sweden and as a Visiting Fellow at the National Institute of Mental Health, NIH. She worked as a senior scientist at ProteinOne Inc., before joining The Ohio State University as an Assistant Professor in 2006. Her research focuses on the molecular action of the glucocorticoid receptor and particularly on how the function of this cellular receptor is altered by infectious agents. Her findings have been published in the Proceedings of the National Academy of Sciences, Molecular and Cellular Endocrinology and Endocrinology. She has written several book chapters and review articles including a review in the Annual Review of Immunology in 2002 which has been cited over 300 times. She serves as a reviewer for several journals.
Academic positions:
2006-present: Assistant Professor, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH
2006-present: Associate Member, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH
2006-present: Assistant Professor, Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH
2006-present: Associate Investigator, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH.
2006-present: Graduate Faculty, Integrated Biomedical Science Graduate Program (IBGP), The Ohio State University.
2006-present: Graduate Faculty, The Ohio State Biochemistry Program (OSBP), The Ohio State University.
2007-2009: Co-director of the Integrative Immunobiology Training Grant Journal Club
2007–present: Graduate Faculty, Molecular, Cellular and Developmental Biology (MCDB) graduate program, The Ohio State University.
2008-present: Member, the Center for Critical Care, The Ohio State University Medical Center, Columbus Ohio.
2009–present: Participating Faculty member, Medical Scientist Program, The Ohio State University Medical Center.
2010-present: Member, The Center for Microbial Interface Biology (CMIB), The Ohio State University.
2010-present: Member. Center for Clinical and Translational Science (CCTS), The Ohio State University Medical Center.
2010-present: Member, OSU Comprehensive Cancer Center (OSUCCC), The Ohio State University Medical Center.
Research interests:
My research has focused on the mechanism of action of glucocorticoid receptors with particular emphasis on the effect of infections agents on glucocorticoid receptor function. I believe this is a poorly investigated arena that would provide useful information for the clinical effectiveness of glucocorticoids.
We have shown that the anthrax lethal toxin can repress glucocorticoid receptor function. This is one of the first demonstrations of an infectious agent interfering with glucocorticoid receptor function. In addition, we now show that this may be a more common phenomenon. We have recently shown that a virus, respiratory syncytial virus can also repress glucocorticoid receptor function by interfering with GR-DNA binding. This paper was published in Endocrinology in February (2011). We are continuing to understand the moecular mechanism of how this respiratory virus intereferes with glucocorticoid receptor signaling. Understanding how infectious agents interfere with glucocorticoid receptor function at the molecular level could provide novel information for the development of more effective therapeutics.
In addition we have developed a whole blood assay to determine glucocorticoid sensitivity that could be useful for the clinic. We have used this assay to look at glucocorticoid receptor function during pregnancy.
Any other information:
Publications:
Peer-review journal publications:
1. Allen, R.G., Lafuse, W.P., Powell, N., Webster Marketon, J.I., Stiner-Jones, L.M., Sheridan, J.F. & Bailey, M.T. (2012) Stressor-induced increases in microbicidal activity of splenic macrophage are dependent on peroxynitrite production. Infection and Immunity. In Press.
2. Burnsides, C., Corry, A., Alexander, J., Balint, C., Cosmar, D., Phillips, G. & Webster Marketon, J.I. (2012) Ex vivo stimulation of whole blood as a means to determine glucocorticoid sensitivity. Journal of Inflammation Research. In press
3. Cormet-Boyaka, E., Rennolds, J., Jolivette, K., Hassan, F., Mehta, P., Tridandapani, S., Webster Marketon, J.I. & Boyaka, P.N. (2011) An NFkB-independent and Erk 1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium. Toxicological Sciences, 125, 418-429.
4. Hinzey, A., Alexander, J., Corry, J., Adams, K.M., Claggett, A.M., Traylor, Z., Davis, I.C., & Webster Marketon, J.I. (2011) Respiratory Syncytial Virus Represses Glucocorticoid Receptor Mediated Gene Activation. Endocrinology, 152, 483-494.
5. Webster Marketon, J.I. & Sternberg, E.M. (2010) The Glucocorticoid Receptor – A Revisited Target for Toxins? Toxins, 2 1357-1380.
6. Yang, E.V., Webster Marketon, J.I., Chen, M., Lo, K.W., Kim, S.J. & Glaser, R. (2010) Dexamethasone activates Epstein Barr Virus lytic replication through the upregulation of immediate early BZLF1 gene expression. Brain Behavior and Immunity, 24, 1089-1096.
7. Kang, Z., Webster Marketon, J.I., Johnson, A. & Sternberg, E.M. (2009) Bacillus anthracis lethal toxin represses MMTV promoter activity through proteolysis of multiple transcription factors. Journal of Molecular Biology, 389, 595-605.
8. Yang, E.V., Kim, S.J., Donovan, E.L., Chin, M., Gross, A.C. Webster Marketon, J.I. Barsky, S.H. & Glaser, R. (2009) Norepinephrine upregulates VEGF, IL-8 and IL-6 expression in human melanoma tumor cell lines: Implications for stress-related enhancement of tumor progression. Brain, Behavior and Immunity, 23, 267-275.
9. Webster Marketon, J.I. & Glaser, R. (2008) Stress hormones and immune function. Cellular Immunology, 252, 16-26.
10. Webster, J.I. & Sternberg, E.M. (2005) Anthrax lethal toxin represses glucocorticoid receptor (GR) transactivation by inhibiting GR-DNA binding in vivo. Molecular and Cellular Endocrinology 241, 21-31.
11. Moayeri, M., Webster, J.I., Wiggins, J.F., Leppla, S.H. & Sternberg, E.M. (2005) Endocrine perturbation increases susceptibility to anthrax lethal toxin. Infection and Immunity 73, 4238-4244.
12. Webster, J.I., Moayeri, M. & Sternberg, E.M. (2004) Novel repression of the glucocorticoid receptor by anthrax lethal toxin. Annals of the New York Academy of Sciences 1024, 9-23.
13. Webster, J.I. & Sternberg, E.M. (2004) Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products. Journal of Endocrinology 181(2), 207-211.
14. Eskandari, F., Webster, J.I. & Sternberg, E.M. (2003) Neural Pathways and their Connection to Inflammatory Diseases. Arthritis Research and Therapy 5, 251-265.
15. Webster, J.I., Tonelli, L., Moayeri, M. Simons, S.S. Jr., Leppla, S.H. & Sternberg, E.M. (2003) Anthrax Lethal Factor Represses Glucocorticoid and Progesterone Receptor Activity. Proceedings of the National Academy of Sciences U.S.A. 100, 5706-5711
16. Webster, J.I. & Carlstedt-Duke, J. (2002) Involvement of Multidrug Resistance Proteins (MDR) in the Modulation of Glucocorticoid Response. Journal of Steroid Biochemistry and Molecular Biology 82, 277-288.
17. Tonelli, L., Kramer, P., Webster, J.I., Wray, S., Listwak, S & Sternberg, E. (2002) Lipopolysaccharide-Induced Oestrogen Receptor Regulation in the Paraventricular Hypothalamic Nucleus of Lewis and Fischer Rats. Journal of Neuroendocrinology 14, 847-852.
18. Webster, J.I., Tonelli, L. & Sternberg, E.M. (2002) Neuroendocrine regulation of Immunity. Annual Review of Immunology 20, 125-63.
19. Kauffmann, H-M., Pfannschmidt, S., Zöller, H., Benz, A., Vorderstemannm B., Webster, J.I. & Schrenk, D. (2002) Influence of pro-/antioxidants and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology 171, 137-146.
20. Tonelli, L. Webster, J.I., Rapp K.L. & Sternberg, E.M. (2001) Neuroendocrine responses regulating susceptibility and resistance to autoimmune/inflammatory disease in inbred rat strains. Immunological Reviews 184, 203-211.
21. Weihua, Z., Mäkela, S., Andersson, L.C., Salmi, S., Saji, S., Webster, J.I., Jensen, E.V., Nilsson, S., Warner, M. & Gustafsson, J-Å. (2001) A role for estrogen receptor beta in regulation of growth of the ventral prostate. Proceedings of the National Academy of Sciences U.S.A. 98, 6330-6335.
22. Yang, D.H., Webster, J., Adam, Z., Lindahl, M. & Andersson, B. (1998) On the induction of acclimative proteolysis of the light-harvesting chlorophyll a/b protein of photosystem II (LHCII). Plant Physiology 118, 827-834.
23. Lindahl, M., Funk, C., Webster, J., Bingsmark, S., Adamska, I. & Andersson, B. (1997) Expression of ELIPs and PS II-S protein in spinach during acclimative reduction of the photosystem II antennae in response to increased light intensities. Photosynthesis Research 54, 227-236.
Book chapters:
1. Webster Marketon, J. I. & Sternberg, E.M. (2008) Neural Immune Interactions. In “Fundamental Immunology” Sixth Edition. ed. W.E. Paul. Lippincott, Williams and Wilkins. ISBN: 978-0781765190, Chapter 32 pp. 1027-1042.
2. Webster Marketon, J.I. & Sternberg, E.M. (2008) Neuroendocrinology of Inflammatory Disorders. In “The Hypothalamus-Pituitary-Adrenal Axis, Neuroimmune Biology, Volume 7”. (ed. A. del Rey, G. Chrousos and H.O. Besedovsky) Elsevier. ISBN: 978-0-444-53040-0, Chapter 17 pp. 321-350.
3. Webster, J.I., Moayeri, M. & Sternberg, E.M. (2006) Anthrax lethal factor represses glucocorticoid and progesterone receptor activity. In “Neural and neuroendocrine mechanisms in host defense and autoimmunity” (Eds. J. Welsh, M. Meagher and E. Sternberg). Springer publishers. ISBN: 0-387-31411-3, Chapter 4 pp. 57-80.
4. Webster, J.I., Tonelli, L. & Sternberg, E.M. (2005) Neural Immune Interactions in Inflammatory/Autoimmune Disease. In “Clinical Neuroimmunology” (ed. J. Antel, G. Birnbaum, H.-P. Hartung and A. Vincent) Oxford University Press. ISBN: 0-1985-1068-3, chapter 32 pp 65-76.
5. Webster, J.I. & Sternberg, E.M. (2004) Neuroendocrine host factors in susceptibility and resistance to autoimmune/inflammatory disease. In “ImmunoEndocrinology in Health and Disease”. Eds. V. Geenen and G. Chrousos. Dekker/CRC Press, ISBN: 0824750608, chapter 20 pp. 393-416.
6. Sternberg, E.M. & Webster, J.I. (2003) Neural Immune Interactions in Health and Disease. In “Fundamental Immunology” Fifth Edition. ed. W.E. Paul. Lippincott, Williams and Wilkins, ISBN: 0-7817-3514-9, chapter 32 pp. 1021-1042.
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