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Prof. Marc-Eric Halatsch

Vice Chair
Department of Neurosurgery
University of Ulm School of Medicine
Albert-Einstein-Allee 23

Brief Biography:

Medical School: Göttingen (Germany), Cincinnati (Ohio), New York City (Mount Sinai School of Medicine), 1987-93

Neurosurgical Residency: University of Göttingen School of Medicine, 1993-96, 1998-2003
M.D. Thesis: “Molecular alterations during pancreatocarcinogenesis: Studies regarding oncogene activation, tumor suppressor gene and adhesion receptor expression”, University of Göttingen School of Medicine, 1996

Postdoctoral Fellowship: Division of Neoplastic Diseases, Mount Sinai School of Medicine, New York City, 1996-98

Board Certification Neurosurgery: 2003

Ph.D. Thesis: “Experimental therapeutic strategies targeting epidermal growth factor receptors in glioblastoma”, University of Göttingen School of Medicine, 2004


Academic positions:

Associate Professor of Neurosurgery and Attending Neurosurgeon, University of Heidelberg School of Medicine, Heidelberg, Germany, 2005-09

Vice Chair, Professor of Neurosurgery and Senior Attending Neurosurgeon, University of Ulm School of Medicine, Ulm, Germany, 2009 to date


Research interests:

Clinical Interests: Neurooncology; Intraoperative Imaging; Spinal Surgery; Pediatric Neurosurgery
Research Interests: Neurooncology; Glioblastoma, Epidermal Growth Factor Receptor, Targeted Therapy


Any other information:


1. Combined Inhibition of HER1/EGFR and RAC1 Results in a Synergistic Antiproliferative Effect on Established and Primary Cultured Human Glioblastoma Cells.
2. A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care.
3. Real-Time Ultrasound Monitoring During Intracranial Needle Biopsies: Operative Results and Detection of Complications in 100 Cases.
4. Aldehyde dehydrogenase and HSP90 co-localize in human glioblastoma biopsy cells
5. Matrix metalloproteinase-2 and -9 in glioblastoma: a trio of old drugs-captopril, disulfiram and nelfinavir-are inhibitors with potential as adjunctive treatments in glioblastoma.
6. Why dapsone stops seizures and may stop neutrophils' delivery of VEGF to glioblastoma.
7. [Intraoperative magnetic resonance imaging. Fifteen years' experience in the neurosurgical hybrid operating suite].
8. Irrigation can cause prolonged intracranial pressure elevations during endoscopic treatment of intraventricular haematomas.
9. Editorial: targeted therapy for glioblastoma multiforme.
10. Erlotinib in glioblastoma: lost in translation?
11. The rationale of targeting neutrophils with dapsone during glioblastoma treatment.
12. Drug combinations enhancing the antineoplastic effects of erlotinib in high-grade glioma.
13. Vertebroplasty combined with image-guided percutaneous cement augmented transpedicular fixation for the treatment of complex vertebral fractures in osteoporotic patients.
14. Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?
15. Ribozyme-mediated inhibition of 801-bp deletion-mutant epidermal growth factor receptor mRNA expression in glioblastoma multiforme.
16. Congenital duplication of the superior sagittal sinus and parietal encephalocele after vacuum extraction delivery.
17. The epidermal growth factor receptor as a therapeutic target in glioblastoma multiforme and other malignant neoplasms.
18. Therapeutic inhibition of the epidermal growth factor receptor in high-grade gliomas: where do we stand?
19. An ultrasound study of brain tissue biomechanics in patients following craniectomy.
20. Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome.
21. Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation.
22. Self-help activities of brain tumour patients and their relatives.
23. Pathogenetic pathways leading to glioblastoma multiforme: association between gene expressions and resistance to erlotinib.
24. Epidermal growth factor receptor pathway gene expressions and biological response of glioblastoma multiforme cell lines to erlotinib.
25. Characteristics of thoracolumbar intramedullary subependymomas.
26. Intracranial dermoid cysts: variations of radiological and clinical features.
27. Minimally invasive approach for the treatment of lateral lumbar disc herniations. Technique and results.
28. [Occipital giant encephalocele].
29. Lumbar subdural haematoma after temporomesial resection in epilepsy patients--report of two cases and review of the literature.
30. Uniform MDM2 overexpression in a panel of glioblastoma multiforme cell lines with divergent EGFR and p53 expression status.


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