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Dr. Parthasarathy Seshacharyulu

University of Nebraska medical centre
Dept of Biochemistry and Molecular Biology 985870 Nebraska Medical Center Omaha Nebraska 68198

Brief Biography:



Parthasarathy Seshacharyulu








Bharathidasan University, TN, India


Bharathidasan University, TN, India


University of Madras, Tamil Nadu, India


Univ. of Neb. Med. Center, Omaha, NE





















Biochemistry and Cancer Biology


Academic positions:

2003 - 2005

Guest Faculty , Department of Biotechnology, Anna University, Chennai

2004 - 2005

Research Assistant , Chennai Medipoint (P) Ltd, Chennai

2005 - 2006

Project fellow granted by UGC, Government of India, Unit of Biochemistry, University of Madras, Chennai, TN

2006 - 2010

Senior Research Fellow, Unit of Glycotechnology, University of Madras, Chennai, TN

2010 - 2013

Postdoctoral Research Associate, Department of Biochemistry and Molecular biology, University of Nebraska Medical Centre, Omaha, NE

2013 - 2015

Senior Research Associate, Department of Biochemistry and Molecular biology, University of Nebraska Medical Center, Omaha, NE

2015 - Present

Instructor, Department of Biochemistry and Molecular biology, University of Nebraska Medical Centre, Omaha, NE


Research interests:

Cancer Biology


Any other information:

Awards and Professional Activities

Recipient of Best Poster Award in 48th Annual Conference of Indian Society of Gastroenterology ISGCON-2007, 15th-18th November, 2007.

Recipient of Best Poster Award in 47th Annual Conference of Indian Society of Gastroenterology ISGCON-2006, 8th-12th November, 2006.

Invited Presentation at National conference on new frontiers and current trends in biotechnology organized by Department of biochemistry, University of Madras, 18th-19th October 2008.

Recipient of award for outstanding science students during 1995-1996 under the national leprosy eradication programme from the Department of Education, Government of Tamil Nadu, India.

Selected to participate in the national level interactive meet on Motivation of Youth in Science on the occasion of India-European Union Ministerial Science conference organized by the Department of Science and Technology, Government of India, February, 2007.

Other Experience and Professional Memberships

2012 -

Member, American Pancreatic association (APA)

2013 -

Editorial Board member, Mutation & Cancer studies, Scigmoid Publications, Cancer-BioMed Central Journal’s

2013 -

Reviewer, Molecular Cancer, Plos One

2014 -

Reviewer, Cancer Research

2015 -

Reviewer, Cancer Management and Research, Clinical and experimental gastroenterology, Gastrointestinal Cancer: targets and Therapy, Edorium Journol of Biochemistry, Cell Health and cytoskeleton, Oncotarget and therapy, Oncology, Gastroeneterology and Hepatology Reports, Cancer and Experimetal and Molecular Pathology.

2016 -

Reviewer, Breast Cancer: Basic and Clinical Research


(i) Research articles

  1. Hein AL, Seshacharyulu P, Rachagani S, Sheinin YM, Ouellette MM, Ponnusamy MP, Mumby MC, Batra SK and Yan Y (2016). PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling. Cancer Research (in press). PMID: 26893480.
  2. Lakshmanan I, Rachagani S, Hauke R, Krishn SR, Paknikar S, Seshacharyulu P, Karmakar S, Nimmakayala RK, Kaushik G, Johansson SL, Carey GB, Ponnusamy MP, Kaur S, Batra SK and  Ganti AK (2016). MUC5AC interaction with integrin β4 enhances the migration of lung cancer cells through FAK signaling. Oncogene (in press). PMID: 26751774.
  3. Seshacharyulu P, Ponnusamy MP, Rachagani S, Lakshmanan I, Haridas D, Yan Y, Ganti AK, Batra SK (2015) Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer. Oncotarget 6 (7): 5164-5181. PubMed PMID: 25686822; PubMed Central PMCID: PMC4467140.
  4. Lakshmanan I, Seshacharyulu P, Haridas D, Rachagani S, Gupta S, Joshi S, Guda C, Yan Y, Jain M, Ganti AK, Ponnusamy MP, Batra SK (2015) Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells. Oncotarget 6 (25): 21085-21099. PubMed PMID: 26035354; PubMed Central PMCID: PMC4673252.
  5. Mimeault M, Rachagani S, Muniyan S, Seshacharyulu P, Johansson SL, Datta K, Lin MF, Batra SK (2015) Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer. Oncotarget 6 (6): 3887-3903. PubMed PMID: 25682877; PubMed Central PMCID: PMC4414161.
  6. Rachagani S, Macha MA, Heimann N, Seshacharyulu P, Haridas D, Chugh S, Batra SK (2015) Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer. Adv Drug Deliv Rev 81:16-33. PubMed PMID: 25453266; PubMed Central PMCID: PMC4465296.
  7. Pandey P*, Rachagani S*, Das S*, Seshacharyulu P*, Sheinin Y, Naslavsky N, Pan Z, Smith BL, Peters HL, Radhakrishnan P, McKenna NR, Giridharan SS, Haridas D, Kaur S, Hollingsworth MA, MacDonald RG, Meza JL, Caplan S, Batra SK, Solheim JC (2015) Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis. Oncotarget 6 (4): 2064-2075. PubMed PMID: 25576918; PubMed Central PMCID: PMC4385836.
  8. Vaz AP, Ponnusamy MP, Seshacharyulu P, Batra SK (2014) A concise review on the current understanding of pancreatic cancer stem cells. J Cancer Stem Cell Res 2: e1004. PubMed PMID: 26451384; PubMed Central PMCID: PMC4594952.
  9. Macha MA, Seshacharyulu P, Krishn SR, Pai P, Rachagani S, Jain M, Batra SK (2014) MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers. Curr Pharm Des 20 (33): 5287-5297. PubMed PMID: 24479799; PubMed Central PMCID: PMC4113605.
  10. Haridas D, Ponnusamy MP, Chugh S, Lakshmanan I, Seshacharyulu P, Batra SK (2014) MUC16: molecular analysis and its functional implications in benign and malignant conditions. FASEB J 28 (10): 4183-4199. PubMed PMID: 25002120.
  11. Seshacharyulu P*, Pandey P*, Datta K, Batra SK (2013) Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Cancer Lett 335 (1): 9-18. PubMed PMID: 23454242; PubMed Central PMCID: PMC3665613.
  12. Pandey P*, Seshacharyulu P*, Das S, Rachagani S, Ponnusamy MP, Yan Y, Johansson SL, Datta K, Fong LM, Batra SK (2013) Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway. Br J Cancer 108 (12): 2590-2600. PubMed PMID: 23598299; PubMed Central PMCID: PMC3694226.
  13. Ponnusamy MP, Seshacharyulu P, Lakshmanan I, Vaz AP, Chugh S, Batra SK (2013) Emerging role of mucins in epithelial to mesenchymal transition. Curr Cancer Drug Targets 13 (9): 945-956. PubMed PMID: 24168188; PubMed Central PMCID: PMC3924542.
  14. Seshacharyulu P, Ponnusamy MP, Haridas D, Jain M, Ganti AK, Batra SK (2012) Targeting the EGFR signaling pathway in cancer therapy. Expert Opin Ther Targets 16 (1): 15-31. PubMed PMID: 22239438; PubMed Central PMCID: PMC3291787.
  15. Rachagani S, Torres MP, Kumar S, Haridas D, Baine M, Macha MA, Kaur S, Ponnusamy MP, Dey P, Seshacharyulu P, Johansson SL, Jain M, Wagner KU, Batra SK (2012) Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy. J Hematol Oncol 5:68. PubMed PMID: 23102107; PubMed Central PMCID: PMC3511181.
  16. Ponnusamy MP, Seshacharyulu P, Vaz A, Dey P, Batra SK (2011) MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells. J Ovarian Res 4 (1): 7-4. PubMed PMID: 21521521; PubMed Central PMCID: PMC3111401.
  17. Parthasarathy S, Dhayaparan D, Jayanthi V, Devaraj SN, Devaraj H (2011) Aberrant expression of epidermal growth factor receptor and its interaction with protein kinase C delta in inflammation associated neoplastic transformation of human esophageal epithelium in high risk populations. J Gastroenterol Hepatol 26 (2): 382-390. PubMed PMID: 21155880.

    (ii) Book Chapters

    1. Vaz AP*, Seshacharyulu P*, Ponnusamy MP, Batra SK. Identification of Ovarian Cancer Stem Cells: Molecular pathways.
    2. Ponnusamy MP, Seshacharyulu P, Batra SK. Recent advancements in the field of ovarian cancer stem cells. Textbook of gynecological oncology.



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