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http://www.webmedcentral.com/images/Header_Logo.giftext/html2011-03-16T22:19:53+01:00http://www.webmedcentral.com/Prof. Sherif H SalahChromosomal Aberrations and Nucleic Acids Systems Affected by Some Egyptian Medicinal Plants used in Treating Female Pregnant Diabetic Rats
http://www.webmedcentral.com/article_view/1758
The influences of medicinal plants Juniperus Phoenicea (Araar), Hyphaene thebaica (Doum), Anastatica hierochuntica (Kafta) and Cleome droserifolia (Sammo) as antidiabetic agents were investigated using female pregnant albino rats. Female rats were injected with 60 mg/kg b.w. alloxan to induce diabetes. Diabetic rats treated orally with the methanol extracts of tested plants till the 19 day of gestation. The present studies include the frequencies of chromosomal aberrations and nucleic acid system of liver in the female pregnant rats and their embryos. The results showed that injection of alloxan caused highly significant increase in chromosomal aberrations as well as in blood glucose levels as a result of diabetes in pregnant females. It also caused a high incidence of chromosomal deviation in embryos and decreased the liver soluble protein contents of female rats and their embryos. These effects in alloxanized animals were treated and improved by ingestion of the methanol extracts of the tested plants (Araar, Doum, Kafta and Somma) in which under their treatments, the inceased level of blood glucose of diabetic rats was deceased. Ingestion with the plants methanolic extracts improved and normalized the effects of diabetes in nucleic acids values of liver tissues. These were accompanied with nucleases (RNAase and DNAase) activities. The inhibited activities of both DNA ase and RNA ase of pregnant rats and their embryos were stimulated and readjusted around the normal values. Also administration of the plants methanol extracts decreased the percentage of chromosomal aberrations in the female rats and embryos. It is concluded that there are some biochemical dynamics which might occur in the metabolism of glucose, nucleic acids and proteins in order to prevent or to reduce the oxidative stress of diabetes by flavonoides treatment.text/html2011-11-22T09:12:09+01:00http://www.webmedcentral.com/Dr. Emeka E OjiyiCervical Cytology at a Teaching Hospital in Northern Ngeria
http://www.webmedcentral.com/article_view/2496
Background: Cervical cytology has not only been useful in screening for cervical intra-epithelial neoplasia (CIN) lesions but is also of value in the characterization of various genital tract infections. Objective: To assess the outcome of cervical cytology in randomly selected patients. Sample/Methods: The sample population were 450 randomly selected sexually active women attending the antenatal, postnatal, gynecology and family planning clinics in the Department of Obstetrics and Gynecology of the University of Maiduguri Teaching Hospital from April 2001 to May 2002.The pap smears of these patients were examined microscopically . A questionnaire assessing the ages of the patients was administered. Results: CIN lesions were identified in 16.2% of the study population. Sixty-six (14.7% of the 450 patients studied had specific infections, 12.9% had non-specific inflammation, 10.7% had HPV associated changes while 45.65 had a normal smear. Conclusion: Cervical cytology, besides screening for CIN lesions, is of value in the diagnosis of genital tract infections.text/html2011-12-03T20:05:24+01:00http://www.webmedcentral.com/Dr. Emeka E OjiyiThe Influence Educational Status on Genital Tract Infections
http://www.webmedcentral.com/article_view/2558
Background: Genital tract infections such as Gardnerella vaginalis vaginosis, trichomoniasis and candidiasis have continued to assume importance because of the particular unique features of their main causative organisms- Gardnerella vaginalis, Trichomonas vaginalis and Candida albicans, and myriads of clinical and pathological changes in affected persons.Aim: To study the association between educational status and genital tract infectionsMethods: The subjects were 450 randomly selected sexually active women attending antenatal, postnatal, gynecology and family planning clinics in the Department of Obstetrics and Gynecology of the University of Maiduguri Teaching Hospital from April 2001 to May 2002. The Pap smear of these patients were examined microscopically for the evidence of Candida albicans, Garnerella vaginalis and Trichomonas vaginalis. A questionnaire assessing the educational status of the patients was administered.Results: Sixty-six (66) of the 450 patients studied had specific infections giving a prevalence rate of 14.7%. Candida albicans, Gardnerella vaginalis, Trichomonas vaginalis and Candida albicans in conjunction with Gardnerella vaginalis contributed 7.1%, 5.15%, 2.4% and 1.8% respectively to this overall prevalence. Their ages ranged between 15 and 64 years, with a mean of 26± 3 years.Conclusion: Those with post secondary educational qualification are at increased risk of acquiring genital tract infections and should be the target in sporadic or organized sexually transmitted infections screening without discriminating other sexually active women.Key words: Cervical cytology, genital tract infections, educational status.