I appreciate the references concerning our article introduced by the reviewer, Dr. Tomonaga. Especially, Vriens et al's article was very interested for me. They classified four distinct subsets of heat-sensitive neurons. The largest group of them is heat-sensitive neurons that respond to both neuroactive steroid pregnenolone sulfate (PS) and capsaicin, suggesting coexpression of TRPV1 and TRPM3. Second and third are heat-sensitive neurons that respond to capsaicin but not PS (TRPV1-expressing), or to PS but not to capsaicin (TRPM3). Fourth, a fraction of heat-activated neurons unresponsive to both PS and capsaicin, indicating the existence of a TRPM3- and TRPV1-independent heat-sensing mechanism. From this, it seems that the remaining neurons after capsaicin treatmen are their fourth type heat-sensitive neurons, accordingly the animals treated with capsaicin at neonate can sense noxious heat normally.
We use cookies on this website to measure and improve performance. By continuing to browse the site, you are agreeing to our use of cookies.
I appreciate the references concerning our article introduced by the reviewer, Dr. Tomonaga. Especially, Vriens et al's article was very interested for me. They classified four distinct subsets of heat-sensitive neurons. The largest group of them is heat-sensitive neurons that respond to both neuroactive steroid pregnenolone sulfate (PS) and capsaicin, suggesting coexpression of TRPV1 and TRPM3. Second and third are heat-sensitive neurons that respond to capsaicin but not PS (TRPV1-expressing), or to PS but not to capsaicin (TRPM3). Fourth, a fraction of heat-activated neurons unresponsive to both PS and capsaicin, indicating the existence of a TRPM3- and TRPV1-independent heat-sensing mechanism. From this, it seems that the remaining neurons after capsaicin treatmen are their fourth type heat-sensitive neurons, accordingly the animals treated with capsaicin at neonate can sense noxious heat normally.