Submited on: 28 Aug 2011 01:38:40 PM GMT
Published on: 29 Aug 2011 09:17:12 AM GMT
 
DDCO
Posted by Ms. Yandira Salinas on 02 Nov 2017 02:56:43 AM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    Coartem threrapy rapidly clears malaria infections in pediatric populations. Yes, it is important because malaria is largest single agent killer in pediatrics.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    No, ACT are the standard of care for malaria treatment, especially in pediatric populations.


  • Are the claims properly placed in the context of the previous literature?

    Yes, ACT are commonly used in the treatment of pediatric malaria. The population studied is appropiate since most of malaria deaths occur in children under the age of 5.


  • Do the results support the claims? If not, what other evidence is required?

    No, the authors assumed that lack of returning to the HF PMV equates cure of malaria infection, that may not be the case.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    NA


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    The study would benefit from a more strict endpoint, perhaps some diagnostic testing post coartem therapy. HFs and PMVs may not be the right setting for this type of study, the drop off rate between treatment and endpoint is too high.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Diagnostic experiments would strengthen the paper, access to these test is a challenge in malaria endemic countries but there are currently new simple, affordable, and reliable diagnostic tools being developed.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    I would like to see this data presented with other ACT data.


  • Other Comments:

    NA

  • Competing interests:
    .
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:

    PMID: 25453091

  • Experience and credentials in the specific area of science:

    PMID: 25453091

  • How to cite:  Salinas Y .DDCO[Review of the article 'Outcomes of Malaria Treatment with Coartem among under five children in Yobe state, North Eastern Nigeria. ' by Abdulkadir J].WebmedCentral 2017;8(11):WMCRW003387
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? No
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? Yes
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? No
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Introduction
    Mortality from malaria in children under five years is about 25% or 30%?

    And without extensive references and punctuation errors.

    Methodology
    As patients were randomized?
    Missed a better description.

    Results
    They do not have adequate statistical analysis.
    Not consistent with the objectives of the study.

    here are many confounding and missing data

    Conclusion

    The conclusion of the study goes beyond the limits. You can not draw this conclusion with the goals and results.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

     

    Teacher of epidemiology

  • How to cite:  Campos M .Outcomes of malaria treatment with coartem among under five children in North Eastern Nigeria[Review of the article 'Outcomes of Malaria Treatment with Coartem among under five children in Yobe state, North Eastern Nigeria. ' by Abdulkadir J].WebmedCentral 2017;2(8):WMCRW00911
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Need Improvement
Posted by Dr. Manas Sarkar on 29 Aug 2011 10:44:31 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    1. Too many missing data points.

    2. No statistical analysis

    3. What is the incidence rate of malaria

    4. It is a simple case report type paper. I would pefer case-control study with in-depth stat analysis.

    5. Children under 5 yrs. may not be selected by the drug earlier. Therefore, they are susceptible to ACT treatment. I would love to see the drug resistance status and a detail study.

    6. However, it is a short limited informative paper written with clear consise English.

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have moe than 6.5 yrs experience in this specific field of science

  • How to cite:  Sarkar M .Need Improvement[Review of the article 'Outcomes of Malaria Treatment with Coartem among under five children in Yobe state, North Eastern Nigeria. ' by Abdulkadir J].WebmedCentral 2017;2(8):WMCRW00909
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Noted
Responded by Mr. Attahir Abubakar on 13 Dec 2011 11:49:53 AM