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Hot Melt Extrusion Technique
By Mr. Sandeep Singhal , Mr. Vikram K Lohar , Mr. Vimal Arora
Submited on: 14 Jan 2011 04:45:12 AM GMT
Published on: 16 Jan 2011 03:38:27 AM GMT
 
Review on Hot Melt Extrusion Technique for EGR 599
Posted by Mr. Benjamin Burdette on 19 Nov 2016 04:15:48 AM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The main claim of the paper is that Hot Melt Extrusion is an efficient technology for manufacturing drug delivery systems and has a wide scope of dosage it forms it can produce.  These claims are important as a majority of drugs currently being produced have low solubility, a problem Hot Melt Extrusion aims to solve.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    No.  This paper is a review paper over a popular technique to address poor drug solubility and doesn't address a new technique just developed.


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Claim did not require any results to be found.  Review paper merely required research into previous literature to make its claim regarding the benefits of Hot Melt Extrusion

     


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No protocal provided or needed, n/a


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Review paper of a technique, no experiments/analysis done, n/a


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Yes.  A comparison between Hot Melt Extrusion and Spray Drying; two seperate techniques that aim to address the same pharmaceutical problem of poor solubility would make the analysis of HME more complete and wouldn't take an enormous amount of work.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes.  The paper covers the technique fairly well and addresses the history of HME to how it works to what it's used for to the techniques used to analyze the products from HME.


  • Other Comments:

    n/a

  • Competing interests:
    .
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:

    .

  • Experience and credentials in the specific area of science:

    Spent ~6 months working with spray drying and hot melt extrusion technology to produce amorphous solid dispersion to address poor drug solubility

  • How to cite:  Burdette B .Review on Hot Melt Extrusion Technique for EGR 599[Review of the article 'Hot Melt Extrusion Technique ' by Arora V].WebmedCentral 2016;7(11):WMCRW003319
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