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Meaning of p-value in Medical Research
By Dr. Brijesh Sathian , Dr. Jayadevan Sreedharan
Submited on: 06 May 2012 05:57:50 PM GMT
Published on: 07 May 2012 04:21:33 PM GMT
 
Meaning of p-value in Medical Research
Posted by Dr. William J Maloney on 10 Feb 2014 09:56:00 PM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The aim of the authors' is to demonstrate the importance of p-value in medical research.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    The aim of the authors is to demonstrate the importance of p-value in medical research.


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    No


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes- this would be a great seminar for anyone involved with medical research.


  • Other Comments:

    A p-value is a measure of how much evidence we have against the null hypothesis. The authors state that p-value is a very important concept for any medical researcher in understanding the research articles published and for making correct statistical and medical inferences in one's own writing.  The authors also caution that ythe p-value should not be interpreted as the probability that the null hypothesis is true.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:

    None

  • Experience and credentials in the specific area of science:

    Clinical associate professor

  • How to cite:  Maloney W J.Meaning of p-value in Medical Research[Review of the article 'Meaning of p-value in Medical Research ' by Sreedharan J].WebmedCentral 2014;5(2):WMCRW002966
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