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"Should Hyperhomocysteinemia be ignored?" A case control prospective study to assess the magnitude of risk associated with hyperhomocysteinemia in chronic stable angina and the implications of Folic acid, B6 and B12 therapy.
By Dr. Sahil Chhabra , Dr. Sarah Chhabra , Mr. Kavish Ramessur , Dr. Sahiba Kukreja , Dr. Namrata Chhabra
Submited on: 10 Dec 2012 06:53:38 AM GMT
Published on: 10 Dec 2012 01:56:45 PM GMT
 
Should Hyperhomocysteinemia be Ignored ? A case control prospective study to assess the magnitude of risk associated with hyperhomocysteinemia in chronic stable angina and the implications of folic acid, B6 and B12 therapy
Posted by Anonymous Reviewer on 14 Mar 2013 07:33:21 PM GMT

  • What are the main claims of the paper and how important are they?

    The main claim is to highlight the importance of hyperhomocystienemia as an independent risk factor in the causation of ischemic heart disease


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes these claima are novel and also not paid proper attention in clinical practice


  • Are the claims properly placed in the context of the previous literature?

    Yes, these are well placed and well compared with conventional risk factors of IHD


  • Do the results support the claims? If not, what other evidence is required?

    Yes, the results well support the claims.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    There are no deviations.


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes, the the methodology is advanced and well described.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    No the article is well written and is complete in itself.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Of course it is outstanding.yes, i would like to discuss the work and also i would like to advance the stydy on a larger population.


  • Other Comments:

    Hyperhomocystenemia should not be ignored,it can be the sole risk factor to cause IHD, and the best thing is that the levels of homocysteine can be lowered down by simple and economical way by supplementing vitamins.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    27 years

  • How to cite:  Anonymous.Should Hyperhomocysteinemia be Ignored ? A case control prospective study to assess the magnitude of risk associated with hyperhomocysteinemia in chronic stable angina and the implications of folic acid, B6 and B12 therapy[Review of the article '"Should Hyperhomocysteinemia be ignored?" A case control prospective study to assess the magnitude of risk associated with hyperhomocysteinemia in chronic stable angina and the implications of Folic acid, B6 and B12 therapy. ' by Chhabra N].WebmedCentral 2013;4(3):WMCRW002608
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