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Ezrin and Metastatic Behavior of Common Estrogen Dependent Tumors

Posted by Dr. Constantino Ledesma-Montes on 24 Jul 2012 04:46:10 PM GMT

What are the main claims of the paper and how important are they?
The main idea of this paper is about ezrin and its application as a biomarker to breast and gynecological cancers.
Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.
Their claims are not novel, there are other articles reviewing this field.
Are the claims properly placed in the context of the previous literature?

Yes
Do the results support the claims? If not, what other evidence is required?

Yes
If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

Not apply
Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

Not apply
Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

There are few errors and mistakes in the language, references are not well done.
Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?
This is well done review which needs to be re-written to be considered as part of the refereces for research or manuscripts.
Other Comments:
No
Competing interests:
None.
Invited by the author to review this article? :
No
Have you previously published on this or a similar topic?:
No
References:
Experience and credentials in the specific area of science:

I am an Oral and Maxillofacial Pathologist with 30 years experience in cancer.
How to cite: Ledesma-Montes C .Ezrin and Metastatic Behavior of Common Estrogen Dependent Tumors[Review of the article 'Ezrin and Metastatic Behavior of Common Estrogen Dependent Tumors ' by Kim T].WebmedCentral 2012;3(7):WMCRW002127

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Ezrin and Metastatic Behavior of Common Estrogen Dependent Tumors

Posted by Anonymous Reviewer on 08 Jul 2012 03:50:29 PM GMT

What are the main claims of the paper and how important are they?
The main idea of this paper is about ezrin protein and its possible application as a clinical biomarker to breast and gynecological cancers. This is a well written review article, with poor format.

Format:
1. conserved globular amino – terminal(N- terminal); domain that bind to carboxy - terminal(C- terminal)
2. Description: inconsistent format
3. References: Reference list inside the text, starts with (1,2), and continues as [31,32].
4. Grammer and Punctuation Errors: whichis barely(page 3 last sentence, you need a space in between), page 4-endothelialICAM-1, needs a space
5. References list: reference -4 correct the ?, inconsistent format. ?.e., compare ref.4 and 5.

Its timing is correct since there are important research articles came on the same topic recently. These are:
1. Konstantinovsky S, Davidson B, Reich R. (2012). Ezrin and BCAR1/p130Cas mediate breast cancer growth as 3-D spheroids. Clin Exp Metastasis. 29(6):527-40.
2. Jiang QY, Xia JM, Ding HG, Fei XW, Lin J, Wu RJ. (2012). RNAi-mediated blocking of ezrin reduces migration of ectopic endometrial cells in endometriosis. Mol Hum. Reprod. May 21.
Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.
This is a review article. There are review articles with similar claims. The positive perspective of this article is that its emphasize to the therapeutic approach for breast and gynecologic cancers.

Other review articles are mostly focusing on structural biochemistry of ezrin protein. Examples:

1. Neisch, A. L, and Fehon R. G. (2011). Ezrin, Radixin and Moesin: key regulators of membrane-cortex interactions and signaling. Curr Opin Cell Biol. 23(4):377-82.

2. Arpin,M., Chirivino, D., Naba, A., and Zwaenepoel, I. Emerging role for ERM proteins in cell adhesion and migration (2011). Cell Adhesion & Migration 5:2, 199-206.

need a space
Are the claims properly placed in the context of the previous literature?

Yes
Do the results support the claims? If not, what other evidence is required?

Yes
If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

N/A
Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

N/A
Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

Please re-work on format.
Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?
This is a good review.
Other Comments:
No
Competing interests:
No
Invited by the author to review this article? :
No
Have you previously published on this or a similar topic?:
Yes
References:

Paxillin- an abstract submission to ENDO meeting.
Experience and credentials in the specific area of science:
None
How to cite: Anonymous.Ezrin and Metastatic Behavior of Common Estrogen Dependent Tumors[Review of the article 'Ezrin and Metastatic Behavior of Common Estrogen Dependent Tumors ' by Kim T].WebmedCentral 2012;3(7):WMCRW002046

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