The paper submitted by Choudhury and colleagues addresses and interesting and important topic in the field of targeted drug delivery. Metronidazole has been used as an essential drug and targeted delivery to the colon remains a core issue. The current study addresses the formulation, stability, and release profile for various ethyl cellulose formulated microspheres. The authors build upon a small body of knowledge that establishes ethyl cellulose as a delivery vehicle for colon-targeted drugs. Overall the paper is well written - some methods (e.g. particle size determination) have not been well defined and should be revised or added. The diction requires some improvements - certain sentences are not comprehensible although the message that the authors wish to convey gets across.

Pharmacists, teaching pharmacy students