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Role of Systemic Enzymes in Infections
By Dr. Sukhbir Shahid
Submited on: 12 Jan 2012 05:47:48 PM GMT
Published on: 13 Jan 2012 06:15:10 PM GMT
 
Enzymes in infections
Posted by Dr. bhumika desai on 21 Feb 2012 01:46:10 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    An excellent review on role of enzymes in infections.

    It could serve as an harbinger for further research in the field.

     

  • Competing interests:
    none
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    alternative medicine

  • How to cite:  desai b .Enzymes in infections[Review of the article 'Role of Systemic Enzymes in Infections ' by Shahid S].WebmedCentral 2012;3(2):WMCRW001514
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thanks for the suggestions
Responded by Dr. Sukhbir Shahid on 11 Jun 2012 05:14:54 AM
Enzymes in infections
Posted by Dr. jaspal mehta on 19 Jan 2012 12:49:13 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The article is an excellent review highlighting the various positive benefits of enzymes in treatment of infectious diseases. Usage of enzymes as supplementary aids in infections needs to be propagated. More studies with various enzyme combinations would be fruitful.

     

  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    supports enzymes and alternative modes of treatment

  • How to cite:  mehta j .Enzymes in infections[Review of the article 'Role of Systemic Enzymes in Infections ' by Shahid S].WebmedCentral 2012;3(1):WMCRW001404
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Dr. Mehta. Thanks. More studies would definitely benefit humankind but present studies also reveal a substantial benefit for its recommendation as a supplementary mode in treatment of infections.
Responded by Dr. Sukhbir Shahid on 20 Jan 2012 01:27:11 PM
Role of Enzymes Reduces Infection Severity
Posted by Dr. Bill Misner on 13 Jan 2012 10:35:53 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This paper is a brilliant review discussing a variety of pathways systemic enzymes reduce the severity of infection.  The author posed serious comments supporting a real adjunct supporting pharmacology resolution of infections. The problem for Enzyme dose is transtion beyond first pass metabolism, which the author addressed proposing enteric-coating protocols.

     

    As a WMC lead faculty, I salute Dr. Sukhbir Shahid 's manuscript, an excellent review of a seldom-discussed/neglected treatment regimen.

     

    Well-done!

     

    Dr. Bill Misner PhD {Emeritus}

  • Competing interests:
    None.
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    Misner B., & Cranton E., Endurance Performance Gains Following Intravenous EDTA Chelation Therapy In A Healthy 60-year Old Athlete. CLINICAL PRACTICE OF ALTERNATIVE MEDICINE, Volume 2, Number 2, Summer 2001: Pages 135 & 136. Bagchi D, Misner B, Bagchi M, Kothari SC, Downs BW, Fafard RD, Preuss HG. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10. PMID: 12837047 [PubMed - indexed for MEDLINE] Misner, B. Food alone may not provide sufficient micronutrients for preventing deficiency. Journal of the International Society of Sports Nutrition. 3(1):51-55, 2006.
  • Experience and credentials in the specific area of science:

     American Alternative Medical Association Commission on Certification

    {Board Certified Alternative Medicine Practitioner}

     
    Ph.D. Holistic Nutrition

    M.S.  Holistic Nutrition

  • How to cite:  Misner B .Role of Enzymes Reduces Infection Severity[Review of the article 'Role of Systemic Enzymes in Infections ' by Shahid S].WebmedCentral 2012;3(1):WMCRW001377
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Dear Dr. Bill Misner, Thank you for your comments. Hope doctors globally realize the role of enzymes and alternative natural ways to combat infections and illnesses with few/no side-effects.
Responded by Dr. Sukhbir Shahid on 17 Jan 2012 01:45:53 PM

Previous Version:

Role of Systemic Enzymes in Infections

Role of Systemic Enzymes in Infections
Posted by Dr. Jamalul Azizi Abdul Rahaman on 10 Jun 2012 03:58:15 PM GMT

  • What are the main claims of the paper and how important are they?

    The paper claims that systemic enzyme therapy may be a useful adjunct in infections where antibiotics have fail. This is important when dealing with resistant organisms 


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    The claims are novel


  • Are the claims properly placed in the context of the previous literature?

    Yes, they are properly placed 


  • Do the results support the claims? If not, what other evidence is required?

    The author has quoted many conditions to support his claims. However, more clinical studies need to be done to further substantiate the claims


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    The paper looks more like a review article. It is not a systematic review or meta-analysis. It's a very long and detailed review 


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Need randomized controlled trials to improve the paper. 


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    The paper is good and so is the idea.  It won't be incorporated in my lecture though


  • Other Comments:

    It is an interesting article and may assist clinicians in dealing with difficult to treat infections. Systemic enzymes may be an adjunct to antibiotics.

    I must admit that I am just a cinician and may not be tuned to the explanation at molecular level. However, it is an interesting concept.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    No
  • Experience and credentials in the specific area of science:

    No experience

  • How to cite:  Abdul Rahaman J .Role of Systemic Enzymes in Infections[Review of the article 'Role of Systemic Enzymes in Infections ' by Shahid S].WebmedCentral 2012;3(6):WMCRW001902
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Dear Dr. Jamalul, Thank u so much for sparing time to review my article. The comments and suggestions will be incorporated in the revised version. But as a matter of fact as u mentioned, more randomized and controlled trials are required especially because the resistance to bacteria is increasing worldwide rapidly. dr. shahid s.
Responded by Dr. Sukhbir Shahid on 14 Jun 2012 05:55:16 AM
review of enzymes in infections
Posted by Dr. Imel Rustogi on 22 Jan 2012 03:04:58 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    excellent review which brings forth the value of enzymes in the modern era of multi-drug resistant infections. 

  • Competing interests:
    none
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    conservatiove management 

  • How to cite:  Rustogi I .review of enzymes in infections[Review of the article 'Role of Systemic Enzymes in Infections ' by Shahid S].WebmedCentral 2012;3(1):WMCRW001413
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Thanks for the review and comments. Increasing resistance to antibiotics calls for research into alternative ways of controlling the various emerging, reemerging and resistant infections and its challenges.
Responded by Dr. Sukhbir Shahid on 23 Jan 2012 03:40:59 PM
enzymes in infections-peer review
Posted by Dr. jaspal s mehta on 23 Dec 2011 05:27:09 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The article has in detail explored the role of enzymes in infections in humans. They are specially valuable in this era of increasing antibiotic resistance. More informations on availability and pediatric dosing of these enzymes would further add to the usefulness of this article.

  • Competing interests:
    none
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    use of alternative medicine in chronic ailments

  • How to cite:  mehta j s.enzymes in infections-peer review[Review of the article 'Role of Systemic Enzymes in Infections ' by Shahid S].WebmedCentral 2012;2(12):WMCRW001299
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Dear Dr. Mehta, Thanks for your review of my article. The suggestions given have been noted and the same shall be incorporated in the revised version. Thank you Dr. Shahid SK
Responded by Dr. Sukhbir Shahid on 24 Dec 2011 05:32:27 AM
review on role of enzymes in infection
Posted by Dr. bhumika s desai on 23 Dec 2011 06:23:30 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Informative article. The usefulness of enzymes have been underrated. It could serve as a good supplement to antibiotics for treament and control of infections. 

  • Competing interests:
    none
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    infection control

  • How to cite:  desai b s.review on role of enzymes in infection[Review of the article 'Role of Systemic Enzymes in Infections ' by Shahid S].WebmedCentral 2012;2(12):WMCRW001297
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Dear Dr. Bhumika, Thank you for your valuable comments on my ms. More studies on usefulness of polyforms of enzymes would aid to enhance the role of enzymes in infections. With mounting drug-resistant infections, co-use of enzymes would aid in decreasing morbidity and mortality due to infections.
Responded by Dr. Sukhbir Shahid on 23 Dec 2011 03:18:29 PM
Review on article with comments by Dr. Sukhbir Shahid ?Role of Systemic Enzymes in Infections?.
Posted by Prof. Minaev V Sergey on 07 Dec 2011 07:06:07 AM GMT

  • Other Comments:

    In medicine hydrolytic enzymes are used for oral application in various indications. A combination of enzyme preparations has better effects than single enzymes. Enzyme preparations are well tolerated and very safe. Systemic Enzyme Therapy represents a special therapeutic approach consisting of an oral application of high doses of hydrolytic animal and plant enzyme combinations. The reviewing article is very actual and contemporary.

    • At the same time in the article has some inaccurate (see the correction on P.2-5).
    • In the part DOSING: comment of preparations and paediatrics doses.

    In conclusion, the article is produce evidence of Systemic Enzyme Therapy in Infections.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:
    None
  • How to cite:  Sergey M V.Review on article with comments by Dr. Sukhbir Shahid ?Role of Systemic Enzymes in Infections?.[Review of the article 'Role of Systemic Enzymes in Infections ' by Shahid S].WebmedCentral 2012;2(12):WMCRW001214
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Thanks for review of my article and the comments. They are highly appreciated. They would be useful for revising my article and the comments would be incorporated in the revised version.
Responded by Dr. Sukhbir Shahid on 07 Dec 2011 01:25:42 PM
A Review of Enzymes Reducing Infection
Posted by Dr. Bill Misner on 24 Nov 2011 05:40:50 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This paper is brilliant, proposing substances that may work with anti-inflammatories and anti-microbial medicines to restore health with a minimal if any side effects. The author supports observed effects of several potent enzymes in vivo when appropriately used to reduce a number of infections and autoimmune diseases.  I would like to see more on the issue po-dose enzyme absorption through gastrointestinal acidic pH exposure [i.e. first-pass metabolism]. Do we need to enteric coat oral enzymes in order to benefit systemic absorption rate. If this paper is revised, I ask the author to address that issue. Very, very interesting paper...this reviewer learned from reading this manuscript!

    Bill Misner PhD

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Graduate Master's and PhD courses on enzymes found in whole plant foods.

  • How to cite:  Misner B .A Review of Enzymes Reducing Infection [Review of the article 'Role of Systemic Enzymes in Infections ' by Shahid S].WebmedCentral 2012;2(11):WMCRW001156
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Dear Dr. Bill Misner, Thank you for your review and the comments on my paper. They are extremely valuable for me and would help for revising my paper. I have noted the points raised and would add it in my revised version. Thanking you again, Best rgds dr. shahid sk
Responded by Dr. Sukhbir Shahid on 24 Nov 2011 05:47:17 AM
 
 
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