Submited on: 09 Nov 2011 03:33:20 PM GMT
Published on: 10 Nov 2011 03:57:26 PM GMT
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? No
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    2. See second part of comment 6.

    6. I wodul separate Materials from Methods in its own section.

    Elaboration of this sentence at the end of the results and discussion is necessary to understand the importance of the results "These validated results of the docking analysis demonstrate the inhibitory effect of BLG-col peptides on MMP-9, hence a newer role can be assigned for BLG-col." Fo rexample some dissertation on the next step to be undertaken to effectively implement the new role of BLG-col (future experiments etc.)

    8. There are sveral missing commas in the structures of the sentnces which soulld make the articel more readable (for example: "the class of enzymes involved in the degradation of extra cellular matrix and surrounding cells, are known to be expressed during cancer cell invasion")

    9. there is no reference to any of the figures that are provided. Also figures showing the results of the bionformatics procedure woudl benefit from indicating the quantitative inormation about the top ranking peptides

  • Competing interests:
    none
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I work with in silico approaches, although not on dicking

  • How to cite:  Nardini C .Docking Studies of Tryptic Peptides from Colostrum β-Lactoglobulin to Matrix Metalloproteinase 9 (MMP-9)[Review of the article 'Docking Studies of Tryptic Peptides from Colostrum β-Lactoglobulin to Matrix Metalloproteinase 9 (MMP-9) ' by S A].WebmedCentral 2012;3(2):WMCRW001458
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Docking Studies of Sryptic Peptides from Colostrum β-Lactoglobulin to Matrix Metalloproteinase 9 (MMP-9) .

    The title shows the word Sryptic. Is it tryptic?or Sryptic?

    The rest of the article is written well and explored techniques and software tools and deduced results.

    This article is a routene work related to protein biology. Article is written well and neately conceived the ideas.

  • Competing interests:
    NO
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    B N Ramya Jyothi, K.Siva Prasad and S.Krupanidhi: 2011: Docking and molecular modeling of the target - Penicillin binding protein -1 A of Haemophilus influenzae. Current trends in Biotechnology and Pharmacy, vol.5 (3) 1310-1315.
  • Experience and credentials in the specific area of science:

    We have done multiple sequence alignment and also docking studies.

  • How to cite:  Sreerama K .Docking Studies of Sryptic Peptides from Colostrum ?-Lactoglobulin to Matrix Metalloproteinase 9 (MMP-9) [Review of the article 'Docking Studies of Tryptic Peptides from Colostrum β-Lactoglobulin to Matrix Metalloproteinase 9 (MMP-9) ' by S A].WebmedCentral 2012;2(11):WMCRW001122
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Thank you very much for comments on our article. The title shows the word Sryptic. Is it tryptic?or Sryptic? Ans- It is Tryptic. Once again thank you very much for your kind attention. With Regards, Rohit
Responded by Mr. Rohit Chougule on 13 Nov 2011 08:10:52 AM