Submited on: 30 Aug 2011 04:09:31 AM GMT
Published on: 30 Aug 2011 12:00:14 PM GMT
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? No
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The topic as well as the proposed methodology are interesting, however I see major points that require clarification and discussion and the lack of number of citations. I also list some minor points that would improve the clarity of the whole work

     

    Major points:

    A discussion on the potential benefits/advantages of Sesamine versus Domperidone or the lacks of Domperidone is crucial to understand the necessity of the current research

    Toxicity Analysis” results would deserve a table or a figure to quantify and support the Discussion section

    “literature survey” is named but not listed
    citation and summarized description of Lipinski's Rule of Five is missing,
    MarvinSketch, AutoDock, OpenTox citation missing

     

    Minor points:

    A figure illustrating the prolactin receptor pathway would be of great help while reading

    Fig 1a and 1b refer only to few of the compounds, this is not properly addressed in the section  "Collection of Compounds", it should be removed from there
    Section “Selection of the receptor” has “?” citation both in html and in pdf

    Hex docked deserves a description

    Discussion section, 1st row I would change “make out”

    what is SDF format? If not relevant in the text it should be removed, or (better) offered as supporting information

  • Competing interests:
    none
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I work in computational biology, I normally use databases and simulation tools to refine in silico biological hypotheses

  • How to cite:  Nardini C .In Silico Techniques for the Identification of Novel Natural Compounds for Secreting Human Breast Milk[Review of the article 'In Silico Techniques for the Identification of Novel Natural Compounds for Secreting Human Breast Milk ' by Aswathy Rajan M].WebmedCentral 2011;2(11):WMCRW001145
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    it is interesting to show a table with  157 compounds (material supplement)

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

      Bioinformatics and drug target selection

  • How to cite:  Isea R .In Silico Techniques for the Identification of Novel Natural Compounds for Secreting Human Breast Milk[Review of the article 'In Silico Techniques for the Identification of Novel Natural Compounds for Secreting Human Breast Milk ' by Aswathy Rajan M].WebmedCentral 2011;2(11):WMCRW001134
1 2 3 4 5 6 7 8 9
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The article is written well and projected software tools such as Q-site finder, Marvinsketch, OpenTox, etc.,. The students fo bioinformatics and others can adopt these tools and plan experiemnts. Under results section small correction: instead of "fitted directly" write "were fit directly". The rest is excellent.

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    If one goes through the google search > S.Krupanidhi, conservation homology among interleukins and Penicillin binding protein A, the references can be retrieved.
  • Experience and credentials in the specific area of science:

    We are having the programme of DBT BIF wherein we execute insilico work related to our phyologeny experiments and docking studies.

  • How to cite:  Sreerama K .http://www.webmedcentral.com/article_view/2120[Review of the article 'In Silico Techniques for the Identification of Novel Natural Compounds for Secreting Human Breast Milk ' by Aswathy Rajan M].WebmedCentral 2011;2(8):WMCRW00910
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