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Dr. Amanjot Kaur Riar

Research Laboratory Manager
Brigham and Women's Hospital
Harvard New Research Building, 77 Avenue Louis Pasteur, Rm 641

Brief Biography:

I joined Brigham and Women’s Hospital (BWH), Harvard affiliated hospital as a Research Manager in the Department of Medicine in 2016. Prior to coming to BWH, I worked as a Senior Research Associate at Mount Sinai School of Medicine, New York. I received B.S in Pharmacy from India and Ph.D. and MBA from Texas Tech University Health Sciences Center, Texas, USA. During my doctoral training, my research project was focused on exploring the molecular mechanisms underlying abnormal neurogenesis in fetal alcohol syndrome. I investigated the effect of ethanol on Tbr2-positive basal progenitor cell proliferation which populate the cortical layers and conversely the mechanism of alcohol-induced cerebral cortex abnormalities resulting from impaired proliferation. I have shown that ethanol inhibits the proliferation of basal progenitors through altering the expression of cell cycle proteins. My studies also revealed that ethanol alters the activity of glycogen synthase kinase 3? (GSK-3?) signaling pathway in central nervous system, where it is predominantly found and modifies various neurogenetic processes by regulating downstream targets. My postdoctoral research involved understanding the role of mitochondrial unfolded protein response (UPR) in SOD1-G93A model of amyotrophic lateral sclerosis (ALS). I investigated the intermembrane space (IMS)-UPRmt in G93A-SOD1 mouse model of familial ALS, since mutant SOD1 is known to accumulate in the IMS of neural tissue and cause mitochondrial dysfunction. Using a mouse model in which G93A-SOD1 was selectively targeted to the IMS, I demonstrated that the IMS-UPRmt could be specifically initiated by mutant SOD1 localized in the IMS.

Academic positions:

2016 – Current Research Manager Brigham and Women’s Hospital- Harvard Medical School Department of Medicine Harvard New Research Building 77 Avenue Louis Pasteur, 641 Boston, Massachusetts 02115 USA Phone: 617-525-7251 Email: ariar@bwh.harvard.edu 2015 – 2016 Senior Associate Researcher Mount Sinai Hospital Icahn School of Medicine 1 Gustave l Levy Place New York, NY 10029 USA 2014 – 2015 Research Associate University of Miami Miller School of Medicine 1475 NW 12th Avenue Miami, Florida 33136

Research interests:

Fetal Alcohol Syndrome Amyotrophic Lateral Scheloris (ALS) Neurosciences Cancer Biology Environmental toxicology Neurobiology Neurogenesis Cerebral cortex Mitochondrial biology Unfolded protein response Substance Abuse Protein misfolding Signal transduction Gene expression Cell cycle

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