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Dr. Alvaro Estevez

Associate Professor
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida
6900 lake Nona Blvd
 

Brief Biography:


1. Gonzalez Solveyra, C., Romeo, H.E., Rosenstein, R.E., Estévez, A.G., and Cardinali, D.P. (1988) Benzodiazepine binding in rat interscapular brown adipose tissue: Effect of cold environment, denervation and endocrine ablations. Life Sci. 42:393-402.
2. Gonzalez Solveyra, C., Estévez, A.G., and Cardinali, D.P. (1989) GABA and its neural regulation in rat adipose tissue. J. Neural. Trans. 78:17-22.
3. Rosenstein, R.E., Estévez, A.G., and Cardinali, D.P. (1989) Time-dependent effect of melatonin on glutamic acid decarboxylase activity and 36Cl-influx in rat hypothalamus. J. Neuroendo. 1:443-447.
4. Estévez A.G., Calamante, G., Goin M. and Jimenez de Asua L. (1991) Tunicamicin inhibits the initiation of DNA synthesis stimulated by prostaglandin F2 in Swiss mouse 3T3 cells. FEBS Lett. 290:239-242.
5. Bley, M.A., Simon, J.C., Estévez, A.G., Jimenez de Asua, L. and Baranao, L. (1992) Effect of follicle-stimulating hormone on insulin-like growth factor I-stimulated rat granulose cell deoxyribonucleic acid synthesis. Endocrinology 131: 1223-1229.
6. Estévez, A.G., Stutzmann, J.-M., and Barbeito, L. (1995) Excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures: Protective effect of riluzole. Eur. J. Pharmacol. 280: 47-53.
7. Estévez, A.G., Radi, R., Barbeito, L., Shin, J.T., Thompson, J.A., and Beckman, J. (1995) Peroxynitrite-induced cytotoxicity in PC12 cells: Evidence for an apoptotic mechanism differentially modulated by trophic factors. J. Neurochem. 65: 1543-1550.
8. Spear, N, Estévez, A.G., Barbeito, L., Beckman, J.S., and Johnson, G.V.W. (1997) Nerve growth factor protects PC12 cells against peroxynitrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase. J. Neurochem. 69: 53-59.
9. Peluffo, H., Estévez, A.G., Barbeito, L. and Stutzmann, J.M. (1997) Riluzole promotes motoneuron survival by stimulating trophic activity produced by spinal astrocyte monolayres. Neurosci. Lett. 228:207-211.
10. Estévez, A.G., Spear, N., Manuel, S.M., Radi, R., Henderson, C.E., Barbeito, L. and Beckman, J.S. (1998) Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. J. Neurosci. 18: 923-931.
11. Estévez, A. G., N. Spear, J. A. Thompson, T. L. Cornwell, R. Radi, L. Barbeito, and J. S. Beckman. (1998) Nitric oxide dependent production of cGMP supports survival of rat embryonic motor neurons cultured with brain derived neurotrophic factor. J. Neurosci. 18: 3708-3714.
12. Spear, N., Estévez, A.G., Johnson, G.V.W., Bredesen, D.E., Thompson, J.A. and Beckman, J.S. (1998) Enhancement of peroxynitrite-induced apoptosis in PC12 cells by FGF-1 and NGF requires p21RAS activation and is suppressed by Bcl-2. Arch. Biochem. Biophys. 356: 41-45.
13. Houston, M., Estévez, A.G., Chumley, P., Aslan, M., Marklund, S., Parks, D.A. and Freeman, B.A. (1999) Binding of xanthine oxidase to vascular endothelium: Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling. J. Biol. Chem. 274: 4985-4994.
14. Estévez, A.G., Spear, N., Peluffo, H., Kamaid, A., Barbeito, L., and Beckman, J.S. (1999) Examining apoptosis in cultured cells after exposure to nitric oxide and peroxynitrite. Meth. Enzymol. 301: 393-402.
15. Viera, L., Ye, Y., Estévez, A.G., and Beckman, J.S. (1999) Immunohistochemical methods to detect nitrotyrosine. Meth. Enzymol. 301: 373-381.
16. Eiserich, J.P., Estévez, A.G., Bamberg, T., Ye, Y.Z., Beckman, J.S. and Freeman, B.A. (1999) Altered microtubule structure and function by post-translational incorporation of nitrotyrosine into a-tubulin. Proc. Natl. Acad. Sci. USA 96: 6365-6370.
17. Estévez, A.G., Crow, J.P., Sampson, J.B., Reiter, C., Zhuang, Y., Richardson, G.J., Tarpey, M.M., Barbeito, L., and Beckman, J.S. (1999) Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science 286:2498-2500.
18. Beckman, J.S., Crow, J.P., and Estévez, A.G. (2000) Response to Toxicity of ALS-linked SOD1 mutants (Technical Comment). Science 288:399a-399b.
19. Estévez, A.G., Sampson, J.B., Zhuang, Y., Spear, N., Richardson, G.J., Crow, J.P., Tarpey, M.M., Barbeito, L., and Beckman, J.S. (2000) Liposome-delivered superoxide dismutase prevents nitric oxide-dependent motor neuron apoptosis induced by trophic factor withdrawal. Free Rad. Biol. Med. 28(3): 437-446.
20. Lang, J.D., Chumley, P., Eiserich, J.P., Estévez, A., Bamberg, T., Adhami, A., Crow, J., and Freeman, B.A. (2000) Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway. Am. J. Physiol. 279: L994-L1002.
21. Cassina, P., Peluffo, H., Pehar, M., Martinez-Palma, L., Ressia, A., Beckman, J.S., Estévez, A.G., and Barbeito, L. (2002) Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J. Neurosci. Res. 67:21-29.
22. Estévez, A.G., Spear, N., Kamaid, A., Thompson, J.A., Cornwell, T.L., Barbeito, L., and Beckman, J.S. (2002) Cyclic GMP prevents expression of neuronal nitric oxide synthase and apoptosis in motor neurons deprived of trophic factors, Neurosci. Let. 326: 201-205.
23. Raoul, C., Estévez, A.G., Nishimune, H., Cleveland, D.W., deLapeyrière, O., Henderson, C.E. Hasse, G., and Pettmann, B. (2002) Motoneuron death triggered by a specific pathway downstream of Fas: Potentiation by ALS-linked SOD1 mutants. Neuron 35: 1067-1083.
24. Beckman, J.S., Estévez, A.G., Barbeito, L., and Crow, J.P. (2002) CCS knockout mice establish an alternative source of copper for SOD in ALS. Free Rad. Biol. Med. 33: 1433-1435
25. Heldebran, M.P., Trushina, E.V., Perez-Terzic, C.M., Bortolon, R., Kovtun, I.V., Terzic, A., Estévez, A., Windebank, A.J., Dyer, R.B., Yao, J and McMurray, C.T. (2003) Single cell analysis of primary neurons: toxicity of the Hungtinton’s Disease protein initiates in the cytoplasm. Proc. Natl. Acad. Sci. USA, 100: 12171-12176
26. Pehar, M., Cassina, P., Viera, L., Vargas, M.R., Beckman, J.S., Estévez, A.G., Barbeito, L. (2004) Motor neuron apoptosis induced by astrocytic porduction of nerve growth factor and nitric oxide. J. Neurochem. 89: 464-473.
27. Pellufo, H., Shacka, J.J., Bisig, G., Ricart, K.C., Martínez-Palma, L., Pritsch, O., Ricart, K., Kamaid, A., Eiserich, J. P., Crow, J.P., Barbeito, L., and Estévez, A.G. (2004) Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine, J. Neurochem. 89:602-612.
28. Cassina, P., Pehar, M., Vargas, M.R., Castellanos, R., Barbeito, A.G, Estévez, A.G., Thompson, J.A., Beckman, J.S., and Barbeito, L. (2005) Astrocyte Activation by Fibroblast Growth Factor-1 and Motor Neuron Apoptosis: Implications for Amyotrophic Lateral Sclerosis. J. Neurochem. 93: 38-46.
29. Ricart, K., Pearson Jr., R.J., Viera, L, Cassina, P., Kamaid, A., Carroll, S.L., and Estévez, A.G. (2006) Interactions between ß-neuregulins and neurotrophins in embryonic motor neuron apoptosis, J. Neurochem. 97: 222-233
30. Schomhoff, C.M., Matsuoka, M., Tummala, H., Johnson, M.A. Estévez, A.G., Wu, R., Kamaid, A., Ricart, K.C., Hashimoto, Y., Gaston, B., Macdonald, T.L., Xu, Z., and Mannick, J.B. (2006) S-nitrosothiol depletion in amyotrophic lateral sclerosis. Proc. Natl. Acad Sci. USA 103: 2404-2409
31. Shacka, J.J., Sahawneh, M.A. Gonzalez, J.D., D’Alessandro, T.D., Barnes, S., and Estévez, A.G. (2006) Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells. Cell Death Differ. 13: 1506-1514
32. Estévez, A.G., Sahawneh, M.A., Lange, P S., Bae, N., Egea, M., and Ratan, R.R. (2006) Arginase—regulation of nitric oxide production is key to the survival of trophic factor-deprived motor neurons. J. Neurosci. 26: 8512-8516
33. Ye, Y.Z., Quijano, C., Robinson, C.V., Ricart, K.C., Strayer, A.L., Sahawneh, M.A., Shacka, J.J., Kirk, M., Barnes, S., Radi, R., Beckman, J.S., and Estévez, A.G. (2007) Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides. J. Biol. Chem. 282: 6324-6337
34. Lu, L., Estévez, A.G., Zheng, L., Suswam, E., Li, Y., Li, X., and King, P.H. (2007) Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes VEGF mRNA and downregulates its expression. J, Neurosci. 27:7929-7938
35. Finocchietto, P., Barreyro, F., Holod, S., Peralta, J., Franco, M.C., Méndez, C., Converso, D.P., Estévez, A.G., Carreras, M.C., Poderoso, J.J. (2008) Control of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: implications for the metabolic syndrome. PLoS ONE 3:e1749
36. Bishop, A., Gooch, R., Eguchi, A., Jeffreys, S., Smallwood, L., Anderson, J. and Estévez, A.G. (2009) Mitigation of peroxynitrite-mediated nitric oxide (NO) toxicity as a mechanism of induced adaptative NO resistance in the CNS. J. Neurochem. 109:74-84
37. Bishop, A. Hobbs, K.G., Eguchi, A., Jeffrey, S., Smallwood, L., Pennie, C., Anderson, J. and Estévez, A.G. (2009) Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: implications for multiple sclerosis. J. Neurochem. 109:93-104
38. Akiba, Y., Sasaki, H., Huerta, P.T., Estévez, A.G., Baker, H., Cave, J.W. (2009) Gamma-aminobutyric acid-mediated regulation of the activity-dependent olfactory bulb dopaminergic phenotype. J. Neurosci. Res. 87:2211-2221
39. Basso, M., Samengo, G., Nardo, G., Massignan, T., D'Alessandro, G., Tartari, S., Cantoni, L., Marino, M., Cheroni, C., De Biasi, S., Giordana, M.T., Strong, M.J., Estevez, A.G., Salmona, M., Bendotti, C., Bonetto, V. (2009) Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis. PLoS One. 4:e8130.
40. Sahawneh, M.A., Ricart, K.C., Roberts, B.R., Bomben, V.C., Basso, M., Sahawneh, J., Ye, Y.-Z., Beckman, J.S., and Estévez, A.G. (2010) Stabilization of mutant and Zn-deficient SOD dimers by Cu,Zn SOD enhances Fas-mediated motor neuron death. J Biol Chem, 285:33885-97
41. Shi, Q., Xu, H., Yu, H., Zhang, N., Ye, Y.Z., Estévez, A.G., Deng, H., and Gibson, G.E. (2011) Inactivation and reactivation of the mitochondria ?-ketoglutarate dehydrogenase complex. J Biol Chem, 286:17640-17648
42. Magrané, J., Sahawneh, M.A., Przedborski, S., Estévez, A.G. Manfredi, G. (2011) Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons. J Neurosci 32:229-242

Articles Submitted/In Preparation
1. Strayer, A.l., Ricart, K.C., Franco, M.C., Bae, N., Ye, Y.Z., and Estévez, A.G. HSP90 inhibition by geldanamycin induces motor neuron apoptosis through activation of Fas. In preparation
2. Byun, Y., Armstrong, J., Dennys, C. Levy, C., Virgilio, J., Gandelman, M., Estévez, A.G. Paradoxical effects of riluzole on cardiotrophin 1 expression. In preparation.
3. Rossi, F.H., Franco, M.C., Estévez, A.G. Cell culture models of amyotrophic lateral sclerosis. Neurology research International, in preparation.
4. Franco, M.C., Ye, Y.-Z., Refakis, C.A., Feldman, J., Stockes, A.L., Basso, M., Melero Fernandez de Mera, R.M., Calingasan, N.Y., Kiaei, M., Rhoads, T.W., Barnes, S., Beal, M.F., Joseph S. Beckman, Mehl, R., Estévez, A.G. Activation of an HSP90 gain-of-function by nitration of a single tyrosine: A mechanism for nitrative stress-induced motor neuron death.

Submitted.
BOOK CHAPTERS AND REVIEWS
1. Spear, N., Estévez, A.G., Radi, R. and Beckman, J.S. (1997) Peroxynitrite and cell signaling. In "Oxidative Stress and Signal Transduction" H.J. Forman and E. Cadenas, Eds. Chapman & Hill, New York. pp. 31-51.
2. Estévez, A.G., Spear, N., Manuel, S.M., Barbeito, L., Radi, R. and Beckman, J.S. (1998) Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture. Prog. Brain. Res. 118: 269-280.
3. Beckman, J.S., Estévez, A.G., Viera, L., Spear, N., Zhuang, Y.X, Ye, Y.Z. and Crow, J.P. (1998) Interactions between peroxynitrite and trophic support in apoptosis and cell survival. In “Pharmacology of Cerebral Ischemia 1998" J. Krieglstein Ed., Medpharm Scientific Publishers, Stuttgart. pp. 243-249.
4. Beckman, J.S., Viera, L., Estévez, A.G. and Teng, R.J. (2000) Nitric Oxide and peroxynitrite in the perinatal period. In: “Seminars in Perinatology” G. Chaudhuri, D. McNellis and C.Y. Spong Eds. W.B. Saunders, Philadelphia. pp. 37-41.
5. Estévez, A.G., Viera, L., Kamaid, A., and Beckman, J.S. (2000) Nitric oxide toxicity in neuronal injury and degeneration. In: "Nitric Oxide and Free Radicals in Peripheral Neurotransmission". S. Kalsner, Ed., Springer-Verlag, New York, NY, pp. 262-278.
6. Estévez, A.G. (2001) Zinc-deficient superoxide dismutase: A possible mechanism for ALS. In “Molecular Mechanism and Therapeutics of Amyotrophic lateral Sclerosis.” K. Abe, Ed., Elsevier, Amsterdam, Netherlands, pp. 71-78.
7. Beckman, J.S., Estévez, A.G., Crow, J.P., Barbeito, L. (2001) Superoxide Dismutase and the death of motoneurons in ALS. TINS. 24: S15-S20
8. Estévez, A.G. and Jordán, J. (2001) Nitric oxide and superoxide, a deadly cocktail. In “Nitric Oxide: Novel Actions, Deleterious Effects and Clinical Potential.” C. C. Chiueh, J.-S. Hong and S.K. Leong Eds. Ann. N.Y. Acad Sci. 926: 207-211
9. Barbeito, L., Pehar, M., Cassina, P., Peluffo, H., Viera, L., Estévez, A.G., Beckman, J.S. (2004) A role for astrocytes in motor neuron loss in Amyotrophic Lateral Sclerosis. Brain Res Review 47: 263-274.
10. Beckman, J.S. and Estévez, A.G. (2005) Superoxide dismutase, oxidative stress and ALS. In “Amyotrophic Lateral Sclerosis.” H. Mitsumoto, S Przedborski and P.H. Gordon Eds. Taylor & Francis, New York, NY. Pp 339-354
11. Franco, F.C, and Estévez, A.G. (2012) Reactive nitrogen species in motor neuron apoptosis. In “Amyotrophic Lateral Sclerosis.” M. H. Maurer Ed. InTech, Rijeka, Croatia, pp 314-334
12. Drechesel, D.A., Estévez, A.G., Barbeito, L., and Beckman, J.S. (2012) Nitric oxide-mediated oxidative damage and progressive demise of motor neurons in ALS. Neurotox Res, in press

 

Academic positions:


* 2010 – present Associate Professor, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida
* 2010 Research Associate Professor, Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon
* 2006 – 2009 Associate Professor, Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York
* 2005 – 2009 Director, Laboratory of Motor Neuron Biology, Burke Medical Research Institute, White Plains, New York
* 2004 – present Associated Investigator (Grado 4), Biology, PEDECIBA, Montevideo, Uruguay
* 2000 – 2005 Assistant Professor, Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL
* 2000 – 2005 Assistant Professor, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL
* 1999 - 2000 Research Assistant Professor, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL
* 1994 - 2003 Assistant Investigator (Grado 3), Biology, PEDECIBA, Montevideo, Uruguay
* 1993 - 1999 Instructor, División Neurociencias, School of Sciences, Universidad de la República, Montevideo, Uruguay

 

Research interests:


The long-term goal of our research is to understand the mechanisms of reactive oxygen and nitrogen species-induced motor neuron degeneration in ALS and other motor neuron diseases to develop new therapeutic strategies for these diseases. Our research focus on three major aspects:
1) the mechanism of mutant SOD toxicity,
2) the role and mechanisms involved in the induction of motor neuron apoptosis by reactive nitrogen species, and
3) how the interactions of motor neurons with surrounding cell populations could be involved in the regulation of cell death.
We have found that the strong oxidant peroxynitrite, formed by the reaction of superoxide with nitric oxide, plays a central role in the induction of motor neuron apoptosis by trophic factor deprivation and activation of the death receptor Fas. Peroxynitrite also seems to play an important role in the induction of motor neuron death by mutant SOD. We have also found that induction of apoptosis by peroxynitrite is not due to unspecific oxidative damage to the cell but rather to the activation of selective death pathways. In particular, we found that oxidative modification of one protein is sufficient to stimulate cell death.

 

Any other information:


Invited lectures
* 1993 “Neurotoxicity mediated by excitatory amino-acids in motor neuron-enriched cultures.” Argentinian Neurochemistry Society Annual Meeting. Villa Giardino, Córdoba, Argentina
* 1994 “Nitric oxide- and peroxynitrite-induced programmed cell death in PC12 cells.” Latin-American Society for Physiology Annual Meeting. Montevideo, Uruguay. 1995 “Peroxynitrite cytotoxicity in PC12 cells.” Uruguayan Society for Biology Annual Meeting, Piriápolis, Uruguay.
* 1998 “Endogenous peroxynitrite formation induces apoptosis in trophic factor deprived motor neurons.” Third International Conference on Biochemsitry and Molecular Biology of Nitric Oxide, Los Angeles, CA
* 1998 “Zinc-deficient SOD induction of motor neuron apoptosis requires nitric oxide.” IX Biennial Meeting of the International Society for Free Radical Research, São Paulo, Brazil.
* 1998 “Induction of Motor Neuron Apoptosis by Trophic Factor Deprivation and by Zinc-Deficient SOD Involves Peroxynitrite Formation.” The ALS Association Young Investigator Workshop, Philadelphia, PA.
* 1999 “Nitric Oxide-dependent induction of motor neuron apoptosis by trophic factor deprivation and zinc-deficient SOD.” College de France, Paris, France.
* 1999 “Effects of ALS-Mutant SOD on motor neuron survival.” Institut de Biologie du Développement de Marseille, Marseille, France.
* 1999 “Role of peroxynitrite in apoptosis of trophic factor-deprived neurons.” Symposium on Neuronal Apoptosis, Tübingen, Germany.
* 1999 “Zinc-Deficient ALS Mutant SOD Induces Motor Neuron Apoptosis by an Oxidative Mechanism Requiring Nitric Oxide.” Forth International Conference on Biochemistry and Molecular Biology of Nitric Oxide, Stockholm, Sweden.
* 1999 “Loss of Zinc from SOD is sufficient to induce motor neuron apoptosis by an oxidative mechanism requiring nitric oxide.” 10th International Symposium on ALS/MND, Vancouver, Canada
* 2000 “Loss of Zinc from SOD induces motor neuron apoptosis by an oxidative mechanism requiring nitric oxide.” Forth Dutch Endo-Neuro Meeting, Doorwerth, Holland
* 2000 “The role of peroxynitrite in motor neuron death.” Interantional Symposium in Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Kurashiki, Japan
* 2000 “Zinc-deficient SOD: A possible mechanism for ALS” Neuroscience Seminar Series Massachusetts General Hospital/Harvard Medical School, Boston, MA
* 2000 “Trophic factors: more is not always better” Neurology Department, Harvard Medical School, Boston, MA
* 2001 “Contrasting actions of nitric oxide in motor neuron death in ALS” Gordon Conference on the Biochemistry of Nitric Oxide. Ventura, California
* 2001 ”Regulation of apoptosis in neurons: Trophic factors and oxidants” VI Latinamerican School of Neuroscience. Montevideo, Uruguay
* 2001 “Superoxide, Nitric Oxide and SOD: A Mechanism for Amyotrophic Lateral Sclerosis Pathogenesis. Seminars in Molecular and Cellular Pathology. Department of Pathology. University of Alabama at Birmingham.
* 2002 “Regulation of Motor Neuron Death by Tophic Factors and Astrocytes In Amyotrophic Lateral Sclerosis.” Seminars in Cellular and Molecular Neurobiology. Instituto de Investigaciones Biológicas Clemente Estable. Montevideo, Uruguay.
* 2002 “Death Factors for Motor Neurons” Seminar Series. Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL.
* 2002 “Induction of motor neuron apoptosis by different stimuli require the production of peroxynitrite” Linus Pauling Institute, Oregon State University, Corvallis, OR.
* 2002 “Tyrosine nitration by superoxide and nitric oxide produced by motor neurons.” Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL.
* 2002 “Induction of apoptosis by peroxynitrite.” Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL.
* 2002 “A new Fas mechanism for the induction of motor neuron apoptosis involving superoxide, nitric oxide and SOD. Neurobiology Retreat. Department of Neurobiology. University of Alabama at Birmingham, Birmingham, AL.
* 2002 “Superoxide dismutase and motor neuron death in ALS” 9th Annual Meeting of the Oxygen Society, San Antonio, TX
* 2003 “Regulation of motor neuron death by trophic factors.”
* 2003 South American School of Neurosciences. IBRO, Montevideo, Uruguay.
* 2003 “Mechanisms of Motor Neuron Apoptosis.” Department of Cell Biology Seminar Series, University of Alabama at Birmingham, Birmingham, AL.
* 2003 “Reactive Nitrogen Species in Motor Neuron Apoptosis.” Department of Physiology. University of Kentucky, Lexington, KY.
* 2003 “Reactive Nitrogen Species in Motor Neuron Apoptosis.” Biomolecular Science Center, University of Central Florida, Orlando, Florida.
* 2003 “Reactive Nitrogen Species in Motor Neuron Apoptosis.” Farber Institute for Neurosciences, Jefferson University Medical College, Philadelphia, Pennsylvania.
* 2003 “Reactive Nitrogen Species-induced Apoptosis.” Burke/Cornell Medical Research Institute, White Plains, New York.
* 2003 “Reactive Nitrogen Species in Motor Neuron Apoptosis.” Department of Medicine, University of Massachusetts Medical School, Worchester, Massachusetts.
* 2004 “”Molecular pathways of peroxynitrite induced apoptosis” Departamento de Medicina, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
* 2004 “Interactions between Zn-deficient and Cu,Zn SOD in ALS” Symposium in Neurodegenerative Diseases, 12th Biennial Meeting of the International Society for Free Radicals, Buenos Aires, Argentina
* 2004 “Molecular pathways of peroxynitrite-induced apoptosis.” Environmental Health Sciences Institute, Oregon State University, Corvallis, Oregon
* 2004 “SOD subunit exchange and motor neuron death.” Amyotrophic Lateral Sclerosis: Mutant SOD1, Neurodegeneration, and Therapeutic Approaches” Muscular Dystrophy Association, University of Massachusetts Medical School, Worcester, Massachusetts
* 2005 “Nitrotyrosine, Muscle and Motor neuron Degeneration” New Approaches to ALS Pathology, Punta del Este, Uruguay
* 2005 “Reactive Nitrogen Species in Motor Neuron Apoptosis”
* 2005 Neurosciences Retreat, Weill Medical College of Cornell University
* 2006 “Reactive Nitrogen Species in Motor Neuron Apoptosis” University of Alabama in Huntsville, Huntsville, Alabama
* 2007 “Reactive Nitrogen Species in Motor Neuron Apoptosis” Seminar Series on Neurosciences, Weill Medical College of Cornell University, New York, New York
* 2007 “Reactive Nitrogen Species in Motor Neuron Apoptosis” Mario Negri Institute, Milan, Italy
* 2007 “Role of Nitration in Peroxynitrite-Induced Apoptosis” Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama
* 2008 “Astrocytes and Reactive Nitrogen Species in Neuronal Cell Death” New York State Spinal Cord Injury Center of Research Excellence, White Plains, New York
* 2008 “Induction of Cell Death by Peroxynitrite: A Relevant Process in Neurodegeneration” Institute Pasteur of Montevideo, Montevideo, Uruguay
* 2008 “Induction of Cell Death by Peroxynitrite: A Relevant Process in Neurodegeneration” Department of Medicine, University Hospital José de San Martín, Facultad de Medicina, Universidad de Buenos Aires
* 2008 “Reactive oxygen and nitrogen species in neurodegeneration: and love and hatred story” Department of Physiology and Molecular Biology, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires
* 2009 “Personalized Medicine: How Much Do We Know”
* 2009 Symposium of the Biology Club and Department of Biological Sciences, University of Alabama in Huntsville “Your Genes, Your Medicine: Personalized Medicine and the Use of Gene Expression to Tailor Medical Care.” Huntsville, Alabama
* 2009 “Role of Nitration in Peroxynitrite-Induced Apoptosis” University of Alabama in Huntsville, Huntsville, Alabama
* 2009 “Hsp90 nitration in peroxynitrite induced cell death” Seminar Series Burke Medical Research Institute, White Plains, New York
* 2009 “Activación de la apoptosis por peroxinitrito: un oxidante, una proteína, un residuo” Seminar series Department of Pharmacology, Facultad de Medicina, Universidad Complutense. Madrid, Spain
* 2009 “Una historia de oxidants y oxidados” Opening conference VI Jornadas de Investigadores Jóvenes, Universidad de Castilla-La Mancha, Albacete, Spain.
* 2009 “Induction of cell death by peroxynitrite: Unspecific oxidative damage versus selective oxidative modifications” University of Missouri, Columbia, Missouri
* 2009 “Induction of cell death by peroxynitrite: Unspecific oxidative damage versus selective oxidative modifications” University of Texas – San Antonio, San Antonio, Texas
* 2010 “Peroxynitrite-induced motor neuron death: nitration of one residue in one protein is enough” Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida
* 2010 “Activation of a HSP90 toxic gain-in-function by tyrosine nitration: A molecular mechanism for peroxynitrite toxicity” Pre-Meeting Workshop “New approaches for examining nitrative and oxidative stress in biology.” 17th Annual Meeting of the SFRBM and SFRR International XV Biennial Meeting, Orlando, Florida
* 2011 “From Unespecific Oxidative damage to Selective Oxidative Modification: Nitration of Hsp90 is Sufficient to Stimulate Cell Death” Seminar co-sponsored by the UAB Center for Free Radical Biology and Medicine and the Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama

 

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I strongly support open access publication of good quality research. Not every paper from every laboratory deserves to be published simple because there are to many low quality experiments. I strongly support an open forum review of manuscripts where bias and conflict of interest in the review of science become evident. Today more than ever, there is at least a perception that some groups of people defines what gets publish in some fields and as a consequence, who receives the resources in that field. Open publication of good quality articles with a transparent review process will plain the field and will strength both the diversity and quality of the scientific literature. I strongly believe that this approach would lead to a quantum leap advancing scientific discovery.

 

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