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Dr. Ileana Manduteanu

PhD
Institute of Cellular Biology and Pathology
8, BP Hasdeu Street, Bucharest
 

Brief Biography:

Personal Data

Full name: Ileana Manduteanu

Date and place of birth: May,5th, 1953, Bucharest, Romania

Address: Institute of Cellular Biology and Pathology “Nicolae Simionescu” 8, B. P. Hasdeu Street, Bucharest 79691, ROMANIA       

Education, degrees and diplomas

1968-1972: College “ Ion Luca Caragiale”, Bucharest, Romania

1972-1977: Faculty of physics, University of Bucharest, Department of Biophysics

1992: PhD in Cellular and molecular biology.

 

Academic positions:

Professional experience, former employers

1977 – 1978: IPRS (Semiconductor Devices Company) - physicist

1978 – 1980: IFA (Atomic Physics Institute) – research physicist in radiobiology

1980 – 1988: IBPC “N, Simionescu” – research in Cellular and molecular biology

1988 – 1989: Faculty of Medicine “Carol Davila” – didactic activities

1989 – present: IBPC “N, Simionescu”

1992: PhD in Cellular and molecular biology

Expert: 1. Expert evaluator at Ministry of Education, Research, Youth and Sport; 2. member of the Committee of Biology and Biochemistry of the National Council of Diploma Certificate of Titles, Diplomas and Academic Certificates. 3 .expert in POSDRU/107/1.5/S/82839, (EXCEL-FIN) Grant

 

Research interests:

Structural- functional characteristics of valvular endothelial cells and their alteration in diseases.

Interaction of endothelial cells and smooth muscle cells with blood cells.

Diabetes- induced modifications of plasma platelets.

The effects of anti-inflammatory drugs on endothelial cells: mechanisms involved.

The use of liposomes as carriers for site-specific delivery of drugs.

Role of cell adhesion molecules, cytokines and chemokines in vascular pathology.

 

Any other information:

Publications

 ISI  Articles

  1. Stan D, Calin M., Manduteanu I., et al. High glucose induces enhanced expression of resistin in human U937 monocyte-like cell line by MAPK- and NF-kB-dependent mechanisms, the modulating effect of insulin, Cell and tissue research, 2011, vol 343 pp 379-387
  2. Manduteanu I., Pirvulescu M., Gan AM., Stan D, Simion V, Dragomir E., Calin M., Manea A., Simionescu M., Similar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cells, Biochem Biophys Res Commun, 2010, vol 391(3) pp1443-8.
  3. Calin MV., Manduteanu I., Dragomir E., Dragan E., Nicolae M., Gan AM., Simionescu M. Effect of depletion of monocytes/macrophages on early aortic valve lesion in experimental hyperlipidemia. Cell Tissue Res. 2009, vol 336(2) pp 237-48.
  4. Manduteanu I., Dragomir E., Calin M., Gan A. M., Stan D., Pirvulescu M., Simionescu M. Resistin up-regulates fractalkine expression in human endothelial cells, lack of additive effect with TNF-alpha. Biochemical and Biophysical Research Commun, 2009, vol 381, pp 95-101,
  5. Dragomir E., Manduteanu I., Calin M., Gan A. M., Stan D., Koenen R.R., Weber C., Simionescu M. High glucose conditions induce up-regulation of fractalkine and MCP-1 in human smooth muscle cells. Thromb Haemost 2008, vol 100, pp1155–1165,
  6.  Manduteanu I., Dragomir E., Voinea M., Capraru M. and Simionescu M. Enoxaparin reduces H2 O2- induced activation of human endothelial cells by a mechanism involving cell adhesion molecules and nuclear transcription factors - Pharmacology, 2007, vol 79(3), pp154-62.
  7.  Dragomir E., M. Tarcol, Manduteanu I., Voinea M., Simionescu M., Aspirin and PPAR-a activators inhibit MCP-1 expression induced by high glucose concentration in human endothelial cells, Vascular Pharmacol, 2006 vol 44, pp 440-449.
  8. Voinea M, Manduteanu I, Dragomir E, Capraru M, Simionescu M. Immunoliposomes Directed Toward VCAM-1 Interact Specifically with Activated Endothelial Cells-A Potential Tool for Specific Drug Delivery, Pharm Res. 2005, vol 22, pp1906-1917
  9. Dragomir E., Manduteanu I., Voinea M., Costache G., Manea A., Simionescu M. - Aspirin rectifies calcium homeostasis, decrease reactive oxygen species, and increase NO production in high glucose-exposed human endothelial cells. Journal Of Diabetes and its complications 2004 vol 18, pp 289-299.
  10. Voinea M., Georgescu A., Manea A., Dragomir E., Manduteanu I., Popov D., Simionescu M. Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes. European Journal of pharmacology, 2004 vol 484, pp 111-118,
  11. Manduteanu I., Voinea M., Antohe F., Dragomir E., Capraru M., Radulescu L., Simionescu M. Effect of enoxaparin on high glucose-induced activation of endothelial cells. European Journal of Pharmacology, 2003, vol 477, pp269-275.
  12. Voinea M., Dragomir E., Manduteanu I., Simionescu M., Binding and uptake of transferrin-bound liposomes targeted to transferrin receptors of endothelial cells.Vascular Pharmacology, 2003, vol 39, pp13-20.
  13. Manduteanu I., Voinea M., Capraru M., Dragomir E., Simionescu M., A novel attribute of enoxaparin: Inhibition of monocyte adhesion to endothelial cells by a mechanism involving cell adhesion molecules. Pharmacology, 2002, vol 65, pp 32-37.
  14. Manduteanu I., Voinea M., Serban G., Simionesu M. High glucose induced enhanced monocytes on to valvular endothelial cells via a mechanism involving ICAM-1, VCAM-1 and CD18.EndotheliuM., 1999, vol 6(4), pp 315-324.
  15. Manduteanu I., Corot C., Simionescu N., Meyer D., Simionescu M. Experimental evaluation of the vascular effects and transport of an iodinated macromolecular contrast medium. Investigative Radiology 1997, vol 32, pp 447-452.
  16. Manduteanu I., Corot C., Simionescu N., Mayer D., Simionescu M. Transport of an iodinated macromolecular contrast medium. Acta Radiol., 1996, pp 353-355.
  17. Navarro P., Caveda L., Breviaro F., Manduteanu I., LampugnanI M.G., Dejana E. Catenin-dependent and independent functions of vascular endothelial cadherin, Journal of Biol. Chem., 1995, vol 270, pp 30965-30972.
  18. Lupu C., Manduteanu I., Calb M., Ionescu M., Simionescu N., Siminescu M., Some major plasmmalemal proteins of human diabetic platelets are involved in the enhanced platelets adhesion to cultured valvular endothelial cells. Platelets, 1993, vol 4, pp 79-84.
  19. Manduteanu I., Calb M., Lupu C., Simionescu N., Simionescu M., Increased adhesion of human diabetic platelets to cultured valvular endothelial cells, J. Sobmicrosc. Cytol. and Pathol., 1992, vol 24, pp 543-547.
  20. Manduteanu I., Vasile E., Simionescu M., Uptake of LDL by valvular endothelial cells in culture. Rev. Roum. Biochim. 1990, vol 27, pp 235-238.

 Scopus  Articles

1.Pirvulescu MM., Gan AM., Stan D, Simion V, Calin M., Butoi E., Tirgoviste CI., Manduteanu I. Curcumin and a Morus alba Extract Reduce Pro-Inflammatory Effects of Resistin in Human Endothelial Cells. Phytother Res. 2011, doi: 10.1002/ptr.3463

2. Manduteanu I., Popov D., Nistor A., Simionescu M., Calf cardiac valvular endothelial cells in culture. Production of glycosaminoglicans, prostacyclin and fibronectin. J. Molec. Cell. Cardiol 1988, vol 20, pp 103-118.

  1. Popov D., Manduteanu I., Synthesis and secretion of 3H-mannose labeled proteins by valvular endothelial cells in culture. Rev.Roum. Biochem. 1987, vol 24, pp 48-54.

Articles in national and international journals

  1. Voinea M., Dragomir E., Manduteanu I., Gene transfer into endothelial cells using transferrin bound cationic liposomes, Proc. Rom Acad, 2004 Series B, vol 3, pp 203-206,
  2. Radulescu L., Manduteanu I., Antohe F., Simionescu M. - Detection of new antigens in activated endothelial cells by high-resolution 2-D gel technology, Electophoresis-Tech NotE., Bio-Rad, 2003, pp2979
  3. Voinea M., Manduteanu I., Simionescu M. Effect of antioxidants on adhesion of monocytes to valvular endothelial cells grown in high glucose concentrations. Current problems and techniques in cellular and molecular biology. 1998, Vol 3, pp 141-145,
  4. Voinea M., Manduteanu I., Simionescu M. Interaction of liposomes with vascular endothelium. Current problems and techniques in cellular and molecular biology. 1998, Vol.3, pp.26-29.
  5. Manduteanu I., Radu A., Simionescu M., Isolation and cultivation of rabbit endocardial endothelial cells. Preliminary data. Morphol. Embriol, 1988, vol XXXIV, pp 165-169.

Communications at International Meetings as abstracts in ISI Thompson international Publications

  1. Gan AM., Butoi E., Stan D., Pirvulescu M., Simion V., Manduteanu I., Simionescu M. Fractalkine promotes a pro-inflammatory phenotype in human smooth muscle cells ,Conference Information: 78th Congress of the European-Atherosclerosis-Society, 2010, jun 20-23, Hamburg Germany, Source: Atherosclerosis supplements Volume: 11 Issue: 2 Pages: 138-138 Published: 2010.Meeting Abstract: MS143
  2. Stan D, Calin M., ButoI E., Gan AM., Pirvulescu MM., Simion V, Manduteanu I., Simionescu M. Resistin and high glucose modulate the expression of fractalkine receptor (CX3CR1) in human monocytes, Conference Information: 78th Congress of the European-Atherosclerosis-Society, jun 20-23, 2010 Hamburg Germany, Source: Atherosclerosis supplements Volume: 11 Issue: 2 Pages: 143-143 Published: 2010, Meeting Abstract: MS169
  3. Pirvulescu MM., Stan D., Gan AM., Simion V., Ionescu-Tirgoviste C., Manduteanu I. Morus alba extract and curcumin reduce resistin induced-human endothelial cells activation by a mechanism involving p38 MAPK, Conference Information: 78th Congress of the European-Atherosclerosis-Society, jun 20-23, 2010 Hamburg Germany, Source: Atherosclerosis supplements Volume: 11 Issue: 2 Pages: 191-191 Published: 2010, Meeting Abstract: MS402.
  4. Manduteanu I., Dragomir E., Calin M., et al. Resistin upregulates ICAM-1, P-selectin and fractalkine in human endothelial cells, source: Atherosclerosis supplements Volume: 9 Issue: 1 Pages: 66-66 Published: 2008
  5. Manduteanu I., Gan AM., Dragomir E., et al. Molecular mechanisms involved in resistin-induced activation of human endothelial cells, Conference Information: 16th European Congress, on obesity, may 14-17, 2008 Geneva Switzerland, Source: International journal of obesity Volume: 32 Pages: S62-S62 Published: 2008
  6. Voinea M., Georgescu A., Manea A., Dragomir E., Manduteanu I., Popov D., Simionescu M. Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes, Conference Information: 24th Conference of the European-Society-for-Microcirculation, AUG 30-SEP 02, 2006 Amsterdam Netherlands, Source: Journal of vascular research Volume: 43 Pages: 18-18 Published: 2006
  7. Manduteanu I., Dragomir E., Voinea M., et al., Molecular mechanisms involved in enoxaparin effect on hydrogen peroxide exposed human endothelial cells, Conference Information: World Congress of Cardiology, SEP 02-06, 2006 Barcelona SPAIN, Source: European heart journal Volume: 27 Pages: 127-127 Published: 2006
  8. Dragomir E., Voinea M., Manduteanu I., et al., High glucose stimulates fractalkine and MCP-1 expression in human aortic smooth muscle cells, Conference Information: 14th Meeting of the International-Society-of-Atherosclerosis, JUN 18-22, 2006 Rome ITALY, Source: Atherosclerosis supplements Volume: 7 Issue, 355-355, Published: 2006 Meeting Abstract: WeP1141
  9. Capraru MS, Dragomir E., Voinea M., Capraru D., Manduteanu I., Signaling pathways involved in CD40L induced fractalkine expression on synovial fibroblasts, Conference Information: Annual European Congress of Rheumatology, JUN 08-11, 2005 Vienna Austria, Source: Annals of the rheumatic diseases Volume: 64 Pages: 130-130 Published: 2005
  10. Capraru MS., Dragomir E., Voinea M., Manduteanu I, Capraru D, Sbarcea A. The effect of CD40 L-CD40 on fraktalkine expression on synovial fibroblasts, Conference Information: Annual European Congress of Rheumatology (EULAR 2004), JUN 09-12, 2004 Berlin GERMANY, Source: Annals of the rheumatic diseases Volume: 63 Pages: 137-137 Published: 2004
  11. Voinea M., Serban G, Manduteanu I., et al., ICAM-1 and VCAM-1 are involved in the increased adhesion of monocytes to valvular endothelial cells grown in high glucose concentrations, Source: Hypertension Volume: 30 Issue: 4 Pages: 65-65 Published: OCT 1997
  12. Manduteanu I., Corot C, Simionescu, N, et al., Ultrastructural investigation of the vascular transport of an iodinated macromolecular contrast medium., Conference Information: Contrast Media Research SymposiuM., jun 17-22, 1995 NaantalI Finland, Source: Academic radiology Volume: 3 Pages: S353-S355 Published: 1996.

Communications at international Meetings

  1. Gan E. M., Manduteanu I., Simion V., Stan D., Pirvulescu M., Butoi E. (Dragomir), M. Calin, Simionescu M. 2010, Efectele rezistinei asupra expresiei fractalkinei si a receptorului CX3RCR1 in celulele musculare vasculare umane. A XXVIII-a sesiune anuala a Societatii Romane de Biologie Celulara, 9- 12 iunie 2010, Constanta.
  2.  Pirvulescu M., Manduteanu I., Gan E. M., Stan D., Simion V., Calin M., Butoi E., Ionescu Tirgoviste C., 2010, Efectele extractului de Morus alba, curcuminei si enoxaparinei asupra celulelor endoteliale umane activate cu rezistina si concentratii crescute de glucoza. A XXVIII-a sesiune anuala a Societatii Romane de Biologie Celulara, 9- 12 iunie 2010, Constanta.
  3. Stan D., Calin M., Gan E. M., Pirvulescu M., Simion V., Butoi E. (Dragomir), Manduteanu I. Efectele concentratiilor crescute de glucoza si ale insulinei asupra expresiei de rezistina in monocitele umane. A XXVIII-a sesiune anuala a Societatii Romane de Biologie Celulara, 9- 12 iunie 2010, Constanta.
  4.  Calin M., Manduteanu I., Dragomir E. (Butoi), Stan D., Simionescu M., 2010, Targeted therapies for cardiovascular diseases using drug delivery nanocarriers, Second International Workshop on Advanced, Nano- and Biomaterials and Their Applications, 15-19 septembrie 2010, Sibiu, prezentare orala.
  5. Simion V., Gan E. M., Stan D., Pirvulescu M., Calin M., Dragomir E., Manduteanu I. 2010, Fractalkine-CX3CR1 interaction on chemotaxis of monocytes towards smooth muscle cells activated with resistin ± high glucosE., potential application for cell therapy with CX3CR1+ progenitor cells. Diaspora în Cercetarea ?tiin?ific? Româneasc? si Înv?t?mântul Superior”, 21-24 Septembrie
  6. Stan D., Calin M., Manduteanu I., Gan E. M., Pirvulescu M., Simion V., Dragomir E., Simionescu M. 2010, High glucose-enhanced expression of Resistin in human monocytes is suppressed by insulin. «Adipose Tissue: a key target for prevention of the metabolic syndrome», Joint Meeting of COST Action BM0602 and FP7 ADAPT, ToulousE., FrancE., June 3 – 5 2010.
  7. Manduteanu I., Dragomir E., M.Calin, Gan AM., Stan D., Pirvulescu M., Simionescu M. 2009, Resistin up-regulates fractalkine expression in human endothelial cells. Comunicare la “The 9Th world Congress on Inflammation 2009, Tokio, Japonia
  8. Manduteanu I., Dragomir E., Calin M., Gan A., Stan D., Pirvulescu M., Simionescu M. 2008, Resistin and high glucose induce ICAM-1, P-selectin and fractalkine in human endothelial cells.44th Annual meeting, RomE., 8-11 september, 2008, Diabetologia, vol 51/Suppl 1, S520.
  9. Manduteanu I., Dragomir E., Voinea M., Gan AM., Stan D, Simionescu M. 2008, Resistin upregulates ICAM-1, P-selectin and Fractalkine In endothelial cells. The 77 th European Atherosclerosis Society Congres, Istanbul, 2008
  10.  Dragomir E., Voinea M., Manduteanu I., Tircol M., Simionescu M. 2006, MAPKs signaling pathways are involved in high glucose induced MCP-1 and fractalkine expression in human smooth muscle cells. The 2nd International Congress of Cellular and Molecular Biology, The 24th Annual Meeting of the Romanian Society for Cell Biology, IasI., June 8-10, 2006 Abstr. Book p. 32.
  11. Manduteanu I., Dragomir E., Voinea M., Capraru M., Simionescu M. 2006, Molecular mechanisms involved in enoxaparin effect on hydrogen peroxide exposed human endothelial cells. World Congress of Cardiology, Barcelona, Spain, September 2-6, 2006
  12. Voinea M., Dragomir E., Manduteanu I., Capraru M., Simionescu M., 2006, VCAM-1 as a target for immunoliposome-mediated drug delivery to activated endothelial cells", ”Targeted Drug Delivery to the Microcirculation” SymposiuM., “24th European Conference on Microcirculation” 30 August-2 Septembrie 2006, AmsterdaM., Netherlands
  13.  Dragomir E., Manduteanu I., Voinea M., M. Tircol, A. Manea, Costache G., Simionescu M., 2006, Mechanisms involved in high glucose induced expression of chemokines involved in monocyte trafficking, the effect of aspirin and PPAR a activators. International Symposium “Advances in Cell and Molecular Biology and Pathology”, Bucuresti - Romania, October, 13, 2006, -
  14.  Dragomir E., Tircol M., Manduteanu I., Voinea M., Simionescu M., 2006, Mechanisms involved in anti-inflammatory drugs effects on MCP-1 expression induced by high glucose in vascular cells. Combating Cardiovascular Diseases and Diabetes Inaugural Workshop of the “Cardio-Diabetology Research Reports and Training Unit”, Bucharest, April 26-28, 2006 -
  15.  Dragomir E., Tircol M., Manduteanu I., Voinea M., Simionescu M. 2005, PPAR-a activators and aspirin inhibit MCP-1 expression induced by high glucose concentration in human endothelial cells, 3rd International Symposium on PPARS EFFICACY AND SAFETY From Basic Science to Clinical Applications, Monte Carlo (Monaco) - March 19-23, 2005
  16. Voinea M., Dragomir E., Manduteanu I., Capraru M., Simionescu M., 2005, VCAM-1 as target for immunoliposome-mediated drug delivery to activated endothelial cells, Vascular Endothelium: Translating Discoveries into Public Health PracticE., CretE., GreecE., June 25-July 2, 2005
  17.  Dragomir E., Tarcol M., Manduteanu I., Voinea M., Manea A., Simionescu M. 2004, Effects and mechanisms of anti-inflammatory drugs involved in high glucose induced MCP-1 expression. Anniversary Workshop “Cell and Molecular Biology-a Key to Defeat Global Risk Diseases: Atherosclerosis, Diabetes and Immune Disorders”, Bucharest, 2004.
  18. Voinea M., Dragomir E., Manduteanu I., Capraru M., Capraru D., Simionescu M., 2003, Immunoliposomes directed toward VCAM-1: vehicles for specific drug delivery to activated endothelial cells, 13th Balkan Biochemical Biophysical Days & Meeeting on metabolic disorders, prezentare orala, 12-15 October, KusadasI., Turkey, 2003, Turkish J. Biochem 28: p.83.
  19. Voinea M., Georgescu A., Manea A., Dragomir E., Manduteanu I., Popov D., Simionescu M., 2003, Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes, poster, ELSO meeting, 20 –24 septembriE., Dresda, Germania, 2003
  20. I.Manduteanu , Antohe F.., Dragomir E., Voinea M., Capraru M., Radulescu L., Simionescu M. 2003, Effects of enoxaparin on high glucose induced activation of human endothelial cells. XIX Congress of the International Society on Thrombosis and Haemostasis, 2003, Birmingham.
  21. Voinea M., Dragomir E., Manduteanu I., Simionescu M., 2002, Binding of VCAM-1 targeted immunoliposomes by activated human endothelial cells induces rises in intracellular calcium concentration, ELSO 2002, NicE., Franta
  22. Voinea M., Dragomir E., Manduteanu I., Simionescu M., 2001, Endothelial cells take up liposmes targeted to transfferrin receptors via a pathway followed by the receptors, EURESCO ConferencE., Membrane Dynamics in Endocytosis, octombrie 2001, Portugal
  23. Voinea M., Dragomir E., Manduteanu I., Simionescu M., 2001, Transferrin-bound liposomes interact with endothelial cell receptors, 12th Balkan Biochemical Biophysical Days: Molecular Biosciences in the Post-Genomic Era, may 2001, Romania
  24. Manduteanu I., Voinea M., Capraru M., Dragomir E., Simionescu M. 2001, Beneficial effect of clexan on glucose-induced activation of valvular endothelial cells, Abstract book, XVIII Congress of the International Society on Thrombosis and Haemostasis, Paris, 2001
  25. Manduteanu , Voinea M., Capraru M., Dragomir E., Simionescu M., 2000, Inhibitory effect of clexane on monocyte adhesion to activated valvular endothelial cells, Abstract Book, First International Congress of The Romanian Society for Cellular Biology, p39-p40, 2000.
  26. Voinea M., Dragomir E., Manduteanu I., Simionescu M., 2000, Liposomes targeted to endothelial receptors: vectors for specific drug delivery, Abstract Book, First International Congress of the Romanian Society for Cellular Biology, p39, 2000.
  27. Manduteanu , Voinea M., Capraru M., Dragomir E., Simionescu M., 2000, Clexane inhibits monocyte adhesion to activated valvular endothelial cells, NATO Advanced Study Institute Congress "Vascular Endothelium: source and target of inflammatory mediators", 2000, Greece.
  28. Voinea M., Dragomir E., Manduteanu I., Simionescu M., 2000, Binding and uptake of liposomes targeted to transferrin receptors by endothelial cells, NATO Advanced Study Institute Congress "Vascular Endothelium: source and target of inflammatory mediators", Greece.
  29. Manduteanu I. , Voinea M., Capraru M., Dragomir E., Simionescu M., 2000, Inhibitory effect of clexane on monocyte adhesion to valvular endothelial cells- 16th International Congress on Thrombosis, mai 2000, Portugal.
  30. Voinea M., Serban G., Manduteanu I., Simionescu M., 1997, ICAM -1 and VCAM-1 are involved in the increased adhesion of monocytes to valvular endothelial cells grown in high glucose concentrations - Second European Research Conference on Blood Pressure and Cardiovascular DiseasE., october 1997, Netherlands.
  31. Simionescu M., Sima A., Popov D., Manduteanu I. 1996. The vascular endothelium in diabetes - induced accelerated atherosclerosis. Texan Conference on “ New horizons in vascular endothelium” Berlin, sept. 24-27.
  32. Manduteanu I., Corot C., Simionescu N., Meyer D., Simionescu M., 1995. Ultrastructural investigation on the vascular transport of an iodinated macromolecular contrast medium. Poster la Contrast Media Research ConferencE., Naatak-Turku, Finland, June 17-22.
  33. Manduteanu I., Calb M., Lupu C., 1992. Cytochemical studies on human diabetic platelets interaction with cultured valvular endotheliuM., 5-th International Congress on Cell Biology, Madrid, Spain, Abstract, vol.1, p. 48.
  34. Manduteanu I., Calb M., Lupu C., 1990. Increased adherence of human diabetic platelets to valvular endothelial cells. Third european congress on cell biology, 2-7 september, 1990, Firenze., Italy.

Communications at national meetings

  1. Pirvulescu M., Manduteanu I., Gan E. M., Stan D., Simion V., Calin M., Butoi E., Tirgoviste C. I.. 2010, Efectele extractului de Morus alba, curcuminei si enoxaparinei asupra celulelor endoteliale endoteliale umane activate cu rezistina si concentratii crescute de glucoza. Congresul anual al Asociatiei Medicale RomanE., 6-8 mai 2010, BucurestI., Romania.

2.Calin M., Stan D., Manduteanu I., Dragomir E., Dragan E., Gan E. M., Simion V., Pirvulescu M., Simionescu M., 2010, Noi abordari terapeutice bazate pe nanotehnologii pentru a modula functiile monocitelor/macrofagelor in procesul inflamator asociat aterogenezei. Sesiunea ?tiin?ific? anual? “IBPC NS” la 31 de ani “Biologia celular? ?i molecular? - în slujba s?n?t??ii omuluI., BucurestI., 2010.

3.Simion V., Gan A. M., Manduteanu I., Stan D., Pirvulescu M., Calin M., Dragomir E., Simionescu M., 2010, Efectele a ctivarii celulelor musculare netede umane cu rezistina ±HG asupra chemotaxiei monocitelor. Sesiunea ?tiin?ific? anual? “IBPC – NS” la 31 de ani “Biologia celular? ?i molecular? - în slujba s?n?t??ii omului”, BucurestI., 2010

4.Gan E. M., Manduteanu I., Simion V, Stan D., Pirvulescu M., Dragomir E., Calin M., Simionescu M. 2010, Efectele rezistinei asupra expresiei fractalkinei si a receptorului CX3RCR1 in celulele musculare vasculare umane. Sesiunea ?tiin?ific? anual? “ IBPC – NS” la 31 de ani “Biologia celular? ?i molecular? - în slujba s?n?t??ii omului”, BucurestI., 2010

5.Stan D., Calin M., Manduteanu I., Gan E. M., Pirvulescu M., Simion V., Dragomir E., Simionescu M., 2010, Efectul insulinei asupra expresiei crescute de resistina indusa de hiperglicemie in monocite umane. Sesiunea ?tiin?ific? anual? “IBPC - NS” la 31 de ani “Biologia celular? ?i molecular? - în slujba s?n?t??ii omului”, BucurestI., 2010

6.Gan A.M., Manduteanu I., Dragomir E., Pirvulescu M., Stan D., Calin M., Simionescu M., 2009, Rezistina si glucoza crescuta induc fractalkina in celulele endoteliale umane. A XXVI-A sesiune anuala a Societatii Nationale de Biologie Celulara, Bistrita, 2009

7.Gan A.M., Manduteanu I., Dragomir E., Pirvulescu M., Stan D., Calin M., Simionescu M., 2009, Rezistina si glucoza crescuta induc fractalkina in celulele endoteliale umane. A XXVI-A sesiune anuala a Societatii Nationale de Biologie Celulara

8.Calin M., Manduteanu I., Dragomir E., Dragan E., Nicolae M., Simionescu M., 2009, Monocytes/ macrophages depletion by administration of clodronate-liposomes increases lipid and collagen content and reduces matrix metalloproteinases activity in hamster atherosclerotic lesions, Societatea Romana pentru Biologie Celulara la 25 anI., workshop aniversar, “From basic science to therapeutic applications”, 7-9 IuniE.,

9. Manduteanu I., Dragomir E., Voinea M., Gan A. M., Simionescu M., 2007, Mechanisms involved in the proinflammatory effects of resistin in human endothelial cells Societatea Romana pentru Biologie Celulara la 25 anI., workshop aniversar, “From basic science to therapeutic applications”, 7-9 IuniE., BucurestI., 2007.

  1. Dragomir E., Trusca V., Gan A. M., MihaI A., Stan D., Fenyo M., Fuior E., Gafencu A., Manduteanu I., Simionescu M., 2007, Inflamatia in ateroscleroza: modularea expresiei genice a fractalkinei si apoE de catre homocisteina si proteina C reactiva (CRP) in celulele peretelui vascular. Simpozion National de Cercetare Stiintifica Medicala de Excelenta, 25-26 octombriE., Sibiu, Romania, 2007.
  2.  Dragomir E., Manduteanu I., Calin M., Gan A. M., Simionescu M., Fractalkine expression is increased by c reactive protein and homocysteine in human endothelial and smooth muscle cells. Societatea Romana pentru Biologie Celulara la 25 anI., workshop aniversar, “From basic science to therapeutic applications”, 7-9 IuniE., BucurestI., 2007.
  3. Voinea M., Manduteanu I., Dragomir E., Sbarcea A., Dragan E., Simionescu M., 2006, Systemic depletion of macrophages by administration of clodronate liposomes aggravate atherosclerotic lesions in hyperlipemic hamsters, The 2nd International Congress of Cellular and Molecular Biology, The 24th Annual Session of the Romanian Society for Cellular Biology, Abstract book, 2006, p. 66
  4.  Dragomir E., Voinea M., Manduteanu I., Tircol M., Simionescu M., MAPKs signaling pathways are involved in high glucose induced MCP-1 and fractalkine expression in human smooth muscle cells. The 2nd International Congress of Cellular and Molecular Biology, The 24th Annual Session of the Romanian Society for Cellular Biology, Abstract Book, 2006, p32
  5. Voinea M., Burlacu A., Dragan E., Dragomir E., Manduteanu I., Simionescu M., 2006, Macrophage “suicide” technique by liposome-encapsulated clodronate”, Workshop: “ Liposomes as drug delivery systems. Potential applications in therapy”, the 11st of November, 2005, Bucharest, Romania.
  6.  Dragomir E., Tircol M., Manduteanu I., Voinea M., Simionescu M. 2005, PPAR-alpha activators and aspirin inhibit MCP-1 expression induced by high glucose concentration in human endothelial cells. International One Day Symposium “New Insights in Molecular Medicine”, the 4th of November, 2005, Bucharest, Romania
  7. Voinea M., Georgescu A., Manea A., Dragomir E., Manduteanu I., Popov D., Simionescu M., 2005, The effect of superoxide dismutase entrapped-liposomes administration on the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes, International One Day Symposium “New Insights in Molecular Medicine”, the 4th of November, 2005, Bucharest, Romania.
  8. Voinea M., Burlacu A., Dragan E., Manduteanu I., Dragomir E., 2005, Macrophage “suicide” technique by liposome-encapsulated clodronate. The XXIIIth Congress of The Romanian Society for Cellular Biology, Sibiu, 9-12 iuniE., Buletin SNBC, nr. 33, p. 94, 2005
  9.  Dragomir E., Tircol M., Manduteanu I., Voinea M., Simionescu M., 2005, Aspirin and PPAR-alpha activators inhibit MCP-1 expression induced by high glucose concentration in human endothelial cells, The XXIIIth Congress of The Romanian Society for Cellular Biology, Sibiu, 9-12 iuniE., Buletin SNBC, nr. 33, p. 91, 2005
  10.  Dragomir E., Manduteanu I., Tircol M., Voinea M., Costache G., Manea A., Simionescu M., 2004, Efectul aspirinei asupra disfunctiilor induse de concentratia crescuta de glucoza asupra celulelor peretelui vascular. Mecanisme de actiunE., a A XXII-a Sesiune Anuala a Societatii Nationale de Biologie Celulara, Sighisoara, 10-13 iuniE., Buletin SNBC, nr. 32, 2004
  11. Voinea M., Georgescu A., Manea A., Dragomir E., Manduteanu I., Popov D., 2004, Efectul administrarii de superoxid dismutaza incorporata in liposomi asupra relaxarii arterelor de rezistenta provenite de la hamsteri diabeticI., A XXII-a Sesiune Anuala a Societatii Nationale de Biologie Celulara, Sesiunea Anuala a SNBC, Sighisoara, 10-13 iuniE., Buletin SNBC, nr. 32, 2004, poster
  12. Manduteanu I., Dragomir E., Voinea M., Capraru M., Simionescu M., 2004, Mechanisms involved in the effects of enoxaparin on high glucose induced activation of human endothelial cells.Poster la Anniversary Workshop “Cell and Molecular Biology-a Key to Defeat Global Risk Diseases: Atherosclerosis, Diabetes and Immune Disorders”, Bucharest, Abstract Book, pag. 52, 2004, poster
  13.  Dragomir E., Tircol M., Manduteanu I., Voinea M., 2003, Concentratia mare de glucoza induce cresterea expresiei MCP-1 in celulele peretelui vascular A XXI Sesiune Stiintifica anuala a Societatii Nationale de Biologie Celulara, 6-10 iunie 2003, Zalau, in Buletinul SNBC, pag.69
  14. Voinea M., Dragomir E., Manduteanu I., Simionescu M., 2003, Interactia liposomilor cuplati cu anti-VCAM-1 cu celulele endoteliale umane activate", poster premiat, A XXI Sesiune Stiintifica anuala a Societatii Nationale de Biologie Celulara, 6-10 iunie 2003, Zalau, in Buletinul SNBC, pag.85
  15. Manduteanu I., Antohe F., Dragomir E., Voinea M., Radulescu L., Capraru M., Simionescu M., 2002, Efectul enoxaparinei asupra expresiei de molecule de adeziune induse de concentratii crescute de glucoza pe celule endoteliale umane.,
  16.  Manduteanu I., Antohe F., Dragomir E., Voinea M., Radulescu L., Capraru M., Simionescu M., Buletinul SNBC p: 198, A XX-a Sesiune Stiintifica Anuala a SNBC, 6-9 iunie 2002, Satu
  17.  Dragomir E., Manduteanu I., Voinea M., Costache G., Simionescu M., 2002, Aspirina reduce mobilizarea calciului intracelular in celule endoteliale expuse la concentratii crescute de glucoza, poster, SNBC, 2002, Satu Mare
  18. Voinea M., Dragomir E., Manduteanu I., Simionescu M., 2002, Cuplarea anti-VCAM-1 la suprafata liposomilor determina legarea specifica de endoteliul vascular activat, prezentare orala, SNBC, 6-9 iunie 2002, Satu Mare
  19. Voinea M., Dragomir E., Manduteanu I., 2001. Liposomii cationici cuplati cu transferina cresc eficienta de transfectie a celulelor endoteliale in cultura. Abstract, Buletin SNBC, nr.29, p.98.
  20. Dragomir E., Manduteanu I., Voinea M., 2001. Efectul aspirinei asupra moleculelor de adeziune celulara exprimate la suprafata endoteliului. Abstract, Buletin SNBC, nr.29, p96.
  21. Manduteanu I., Voinea M., Capraru M., Dragomir E., Simionescu M., 2001.Enoxaparina (clexan) reduce activarea celulelor endoteliale valvulare indusa de concentratii crescute de glucoza. Abstract, Buletin SNBC, nr.29, p.86
  22. Manduteanu I., Voinea M., State M., Simionescu M.,1999. Efectul clexanului asupra adeziunii monocitelor la endoteliul valvular.Abstract, Buletin SNBC, nr 27, p.61.
  23. Voinea M., Manduteanu I., Simionescu M.,1998. Interactia liposomilor cu endoteliul vascular. Abstract, Buletin SNBC, nr26, p.69.
  24. Voinea M., Manduteanu I. 1998. Efectul antioxidantilor asupra adeziunii monocitelor la celule endoteliale valvulare cultivate in conditii de glucoza crescuta. Abstract Buletin SNBC, nr.26, p.68.
  25. Manduteanu I., Voinea M., Serban G., Simionescu M., 1997. Implicarea moleculelor de adeziune celulara ICAM-1 si VCAM-1 in adeziunea monocitelor la celule endoteliale valvulare cultivate in concentratii crescute de glucoza, Sesiunea anuala a SNBC, Abstract, Buletin SNBC, nr.25, p.69.
  26. Manduteanu I., Serban G., Milea T., Simionescu M., 1996. Expresia moleculelor de adeziune de catre celule endoteliale valvulare si celule endoteliale aortice bovine expuse la concentratii crescute de glucoza. Sesiunea stiintifica anuala a SNBC, Abstract, Buletin SNBC nr.24, p.76.
  27. Manduteanu I., Serban G., Simionescu N., Simionescu M., 1995. Amplificarea adeziunii monocitelor la celule endoteliale valvulare cultivate in prezenta de glucoza crescuta. SNBC, Abstract Buletin SNBC, nr 23, p. 59.
  28. Manduteanu I., Serban G., Simionescu N., Simionescu M., 1995. Adeziunea celulelor U937 la celule endoteliale expuse la concentratii crescute de glucoza. Poster la Colocviul “Louis Pasteur- Stiinta in serviciul omului”, BucurestI., 4-6 oct.
  29. Manduteanu I., Lampugnani M.G., Navarro P., Dejana E., 1994. Localizarea ultrastructurala a caderinei endoteliale vasculare si a PCAM-ului in diferite tipuri celulare. Sesiunea stiintifica anuala a SNBC, Abstract, Buletinul SNBC, nr 22, p, 80.
  30. Manduteanu I., Lupu C., Simionescu M., Simionescu N, 1993. odificarile celulelor endoteliale valvulare in diabetul experimental, Sesiunea stiintifica anuala a IBPC, Abstract Buletin SNBC, nr21, p.58.
  31. Lupu C., Manduteanu I., Calb M., Simionescu M., Simionescu N., 1992. Implicarea unor glicoproteine din membrana plachetelor diabetice in adeziunea crescuta a plachetelor la CEV in cultura. Sesiunea stiintifica anuala a IBPC.
  32. Manduteanu I., Lupu C, Calb M., Simionescu M., 1992. Caracterizarea biochimica a suprafetei celulelor endoteliale valvulare in concentratii crescute de glucoza, Sesiunea sttintifica anuala a IBPC, Abstract Buletin SNBC, nr 20, p.51.
  33. Manduteanu I., 1991. Integrinele si rolul lor in adeziunea celulara. Referat, Sesiunea sttintifica anuala a SNBC, Abstract, Buletin SNBC, nr 19, p. 18.
  34. Manduteanu I., Calb M., Lupu C., 1990. Cresterea adeziunii plachetelor umane diabetice la celulele endoteliale valvulare in cultura. Sesiunea stiintifica anuala a IBPC. Abstract, Buletinul SNBC, nr18, p.57.
  35. Bulla A., Manduteanu I., Nistor A., Simionescu M., 1987. Caracterizarea partiala a LDL transcitate prin celulele endoteliale valvulare in cultura. Sesiunea anuala a IBPC. Abstract in Buletinul SNBC, nr 12, p.12.
  36. Manduteanu I., Lupu F., Simionescu M., 1987. Date preliminare privind organizarea citoschelrtului celulelor endoteliale ale valvelor cardiace. Sesiunea stiintifica anuala a IBPC. Abstract, Buletinul SNBC, nr 12, p. 69.
  37. Manduteanu I., 1986. Celule endoteliale in cultura. Buletin SNBC nr 10, p.86.
  38. Manduteanu I., Simionescu M., 1986. Proprietati ala celulelor endoteliale valvulare in cultura. Abstract Buletin SNBC, nr8, p.43.
  39. Badea M., Manduteanu I., Nistor A, Bulla A., Horer O., 1986. Interactia dintre LDL umane si celulele endoteliale valvulare bovine. Masuratori de fluiditate plasmalemala. Sesiunea stiintifica anula a IBPC. Abstract, Buletin SNBC, nr 9, p.86.
  40. Manduteanu I., Nistor A., Bulla A., Simionescu M., 1986. Preluarea de 125LDL de catre celulele endoteliale in cultura. Sesiunea anuala a IBPC. Abstract, Buletinul SNBC, nr9, p. 80.
  41. Manduteanu I., Popov D., Simionescu M., 1984. Izolation, culture and partial caracterization of endothelial cells from atrio-ventricular valves. Fourth US-Roumanian Workshop on Biomedical research: Celular and molecular events in Atherogenesis. Program -abstracts, p.49.
  42. Manduteanu I., Popov D., Alexandru D., Simionescu M., Simionescu N., 1984. Incorporarea a 35 SO4 de catre celulele endoteliale din endocard, Buletinul SNBC, nr 3, p.52.
  43. Manduteanu I., Simionescu M., Abstract, Buletinul SNBC, 3, p51.
  44. Manduteanu I., Simionescu M., Simionescu N., 1984. Izolarea si cultivarea de celule din endocard. Sesiunea stiintifica anuala a IBPC.
  45. Manduteanu I., Simionescu M., Simionescu N., 1983. Izolare si cultivarea de celule din endocard. Date preliminare. Sesiunea stiintifica anuala a IBPC.
  46. Manduteanu I., Simionescu M., Simionescu N., Bergeron J., 1982. Cercetari radioautografice asupra receptorilor la prolactina din inima, ficat si suprarenala. Sesiunea sttintifica anuala a IBPC.
  47. Manduteanu I., Bergeron J., Simionescu M., 1981. Cercetari radioautografice asupra receptorilor la serotonina din pancreas. Analiza microscopo-optica. Sesiunea stiintifica anuala a IBPC.

Monograph chapter

Vasile E., Manduteanu I., 1991. Transport of LDL in “Endothelial transport of macromolecules: “Transcytosis and endocytosis”, Simionescu Simionescu M N., editors. Cell Biology Reviews, 25, 1, 39-41.

Book chapters

  1. Manduteanu I. et al, Mechanisms involved in the anti-inflammatory effects of heparin. - In “Cellular Dysfunction in Atherosclerosis and Diabetes-Reports from Bench to Bedside”, D.(eds), 363-372, 2004.
  2. Butoi E. (Dragomir) and Manduteanu I., Fractalkine and its receptor in vascular dysfunction. ‘From Vascular Cell Biology to Cardiovascular Medicine’, Ed: A. Georgescu, F. Antohe., published by Research Signpost Transworld research network, ISBN - 978-81-7895-503-2, in press 2011.
 

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Very good and very usefull for disseminating good science.

 
 
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