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Dr. Antoine Taly

Researcher
CNRS / IBPC
13 rue Curie Paris
 

Brief Biography:


2009 –
Researcher (chargé de recherche) at CNRS
Laboratoire de Conception et Application de Molécules Bioactives. UMR 7199 (Université de Strasbourg / CNRS)
- Modeling Ligand Gated Ion Channels (nicotinic, GABA and P2X receptors) activation mechanism with homology modeling and normal mode analysis;
- Study of the binding of ligands (docking);
- study of pathological mutations related to epilepsy and myasthenia.

2006 – 2009
Post-doctoral researcher
Université de Strasbourg, In the lab of Prof. Martin Karplus.
- Modeling nicotinic acetylcholine receptors activation mechanism with homology modeling and normal mode analysis.
- Study of the binding of ligands (docking)

2008 – 2009
Research contract with Servier
Université de Strasbourg
- Preparation of structures for virtual screening.

2003 – 2006
Post-doctoral researcher
Institut Pasteur, In the lab of Prof. Jean-Pierre Changeux:
- Modeling nicotinic acetylcholine receptors activation mechanism with homology modeling and normal mode analysis.
--> Proposed a model for the activation mechanism that was recently validated experimentally.
- Support to experimentalists in the analysis and design of experiments.
 

1999 – 2003
Ruprecht-Karls-Universität Heidelberg/Université Paris Sud (Paris XI)
PhD, Computational Molecular Biophysics
In the lab of prof. Jeremy Smith/Prof. Pierre Sebban
Advisor: Matthias Ullmann

 

Academic positions:


Researcher at CNRS

Teacher at the undergraduate interdisciplinary program "Frontières du Vivant" at Université Paris Descartes

 

Research interests:


Modeling of protein structure/function relationships including allostery.

Current focus on the gating mechanism of ligand gated ion channels (nicotinic, GABA and P2X receptors). Analysis of the effect of mutations and effect of ligands including drugs.
Specialties

Homology Modeling, Docking, Normal Mode Analysis, Molecular Dynamics.

 

What I think of the idea behind WebmedCentral:


Having fast and transparent publication process is a good idea. I am curious to se how a rigourous publication scheme can be maintained with post-processing reviewing and hope to contribute on that aspect.