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Mr. Rajeev Singla

SERB-Young Scientist/PI
Division of Biotechnology, Netaji Subhas Institute of Technology, University of Delhi, Azad Hind Fauz Marg, Sector-3, Dwarka-110078

Brief Biography:

My research work is focused on molecular modeling, computer aided drug design with model development for 2D-QSAR, 3D-QSAR equations, Pharmacophore mapping, Docking mainly of bioactive molecules, Synthesis of heterocyclic compounds(Conventional method as well as microwave synthesis), Green Chemistry, Evaluation of biological profile using in vitro models. I studied on the anti candidal activity of 1,2,4-Triazoles and generated robust 2D-QSAR and 3D-QSAR equations to get lead molecules. I had synthesized 1,2,4-Triazoles and evaluated their antioxidant, antimicrobial and anticancer activity. In addition, I had synthesized chalcones, 2-Pyrazolines, 1,5-benzodiazepines, Tetracyclic compounds(Novel Scaffold) and elucidating their structures. In addition to this core contribution, I had also assisted fellow members to synthesize triazolothiadiazoles, imidazolones, quinazolinones, benzimidazoles and evaluation of in vivo anticancer activity. My area of interest has a bend for natural products also. I had evaluated antioxidant, antimicrobial, in vitro and in-vivo antihypertensive activity of cocos nucifera endocarp extracts and isolating its active constituents. At the time of swine flu pandemic, I had hypothesized a cost effective therapy with possible mechanism of action. At present, I am working on green chemistry and 2D-QSAR; 3D-QSAR models to augment the drug discovery.


Academic positions:

1. July, 2012 to present  as Principal Investigator(Young Scientist-DST Project), Division of Biotechnology, Netaji Subhas Institute of Technology, University of Delhi.
2. Honorary Post: Editor-in-Chief, Indo Global Journal of Pharmaceutical Sciences ISSN 2249 - 1023, Since January 2011. An international quarterly published, refereed journal.
3. Oct, 2011 to April 2012: Assistant Professor & Vice Principal, Sadbhavna College of Management & Technology, Raikot, Punjab, India
4. 12th Jan 2011- 5th Oct, 2011: Assistant Professor, School of Pharmaceutical Sciences, Jaipur National University, Rajasthan, India
5. 1st July’10 – 10th Jan 2011: Lecturer in Pharmacy & Training cum Placement Officer, Member Secretary of IAEC, Joint Secretary of VPC, Vaish Institute of Pharmaceutical Education & Research, Haryana, India
6. 21st Oct’09 – 30th June’10: Lecturer in Department of Pharmaceutical chemistry, Head of Training & Placement Cell, Shri Gopichand College of Pharmacy, U.P affiliated to U.P.T.U, Lucknow, India.


Research interests:

Molecular modeling, Computer aided drug design with model development for 2D-QSAR, 3D-QSAR equations, Pharmacophore mapping, Docking mainly of bioactive molecules, Synthesis  of bioactive molecules, in vitro and in vivo screening, Extraction & Isolation of Phytoconstituents.


Any other information:


1. Rajeev K Singla, Varadaraj Bhat G. QSAR model for predicting the fungicidal action of 1,2,4-triazole derivatives against candida albicans. Journal of enzyme inhibition and medicinal chemistry. October 2010; 25(5): 696-701.  DOI: 10.31.09/14756360903524296.
2. Rajeev K. Singla, Babita Aggarwal, Mohd. Ali, Vijender Singh. Isolation and characterization of phytoconstituents from the stem of Ichnocarpus frutescens.Chinese Journal of Natural Medicines. 2010, 8(6); 401-404. doi: 10.3724/SP.J.1009.2010.00401.
3. Rajeev K. Singla, Girish R. Bankar, Pawan G Nayak, Punit Bansal, Piya Paul, K S R Pai,  Varadaraj G. Bhat. Vasorelaxant and antihypertensive effect of cocos nucifera linn. Endocarp on isolated rat thoracic aorta and DOCA salt induced hypertensive rats. Journal of Ethnopharmacology.2011; 134: 50-54.  doi:10.1016/j.jep.2010.11.047
4. Rajeev K Singla, Varadaraj Bhat G. Honey Bee sting and venom offering active as well as passive immunization could reduce Swine flu pandemic A(H1N1). Medical Hypotheses. 2010; 74(3) : 617-618.  
5. Soma Jayalakshmi, Ashoke K Ghosh, Birendra Shrivastava, Rajeev K Singla. Preliminary Investigation of Antipyretic Activity of Trinpanchmool Extracts. International Journal of Phytomedicine. 2011; 3: 147-150.
6. Preliminary investigation of antipyretic activity of trinpanchmool extracts. International Journal of Phytomedicine, vol. 3, no. 2, pp. 147–150, 2011.
7. John O. Igoli, Alexander I. Gray, carol J. Clements, Phooran kantheti, Rajeev K Singla. Anti-trypanosomal activity of isolated constituents from lichen Cetraria islandica: Possibly by inhibition of Riboflavin kinase. Bioorganic and medicinal chemistry letters. 2012. (Communicated) For more details, visit     http://scholar.google.co.in/citations?hl=en&user=EmfbCekAAAAJ&view_op=list_works&cstart=20


What I think of the idea behind WebmedCentral:

I will do anything for science and willing to join groups who are stepping towards it.


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