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Abstract: Background:  We report a 20 y.o. female with chronic cyclic edema who has a homozygous R116H substitution in the SLC12A1 gene. The patient was normotensive without any serum electrolyte or metabolic acid-base abnormalities. Urine studies showed significantly reduced 24 hr excretion of Na+, K+, Cl-, Ca2+, and Mg2+..

Abstract : It has been found that potassium bicarbonate supplements make the urine sufficiently alkaline that uric acid can be efficiently kept soluble and thus successfully excreted. This will prevent the destructive effects associated with gout. Some of the circumstances causing gout are discussed as well as some other ameliora..

Abstract : Rheumatoid arthritis (RA) is a chronic systemic connective tissue disease with multiple organ impairment and unknown aetiology.Rheumatoid arthritis leads to activation of immune processes and formation of abnormal antibodies. They participate in antigen-antibody complexes and accumulate in various tissues (mainly in sy..

Abstract : Infections of the urinary tract and asymptomatic bacteriuria become more frequent with age in both genders. The ascending path of infection dominates in elderly patients. Very important factor is the weakening of the protective mechanisms due to changes in the glomerules and the tubular interstitial system of the kidne..

Abstract : Diabetic Nephropathy (DNP) is a chronic disease caused by diabetes that leads to end stage renal diseases. Although various pathological mechanisms have been proposed till date on the progression of DNP, the exact cause of this disease is still unknown. Here, we have focused on the modifications of low density lipoprot..

Abstract : Ectopic Adrenocorticotropic (ACTH) secreting tumors are unusual causes of Cushing’s syndrome. Etiologies include small cell lung cancer (SCLC), medullary thyroid carcinoma and pheochromocytoma (1, 2, and 3) or carcinomas (such as hypernephromas, colon cancer, and paragangliomas). Neuroendocrine tumors of thymus are ..

My opinion: Previous quantitative approaches that model acid-base physiology and used to predict the equilibrium pH rely on the mathematical convenience of electroneutrality/charge balance considerations (1-4). This fact has caused confusion in the literature, and has led to the assumption that charge balance/electroneutrality is ..

Abstract : Diabetic Nephropathy (DNP) is a chronic disease caused by diabetes that leads to end stage renal diseases. Although various pathological mechanisms have been proposed till date on the progression of DNP, the exact cause of this disease is still unknown. Here, we have focused on the modifications of low density lipoprot..

Abstract : Infections of the urinary tract and asymptomatic bacteriuria become more frequent with age in both genders. The ascending path of infection dominates in elderly patients. Very important factor is the weakening of the protective mechanisms due to changes in the glomerules and the tubular interstitial system of the kidne..

Abstract : Rheumatoid arthritis (RA) is a chronic systemic connective tissue disease with multiple organ impairment and unknown aetiology.Rheumatoid arthritis leads to activation of immune processes and formation of abnormal antibodies. They participate in antigen-antibody complexes and accumulate in various tissues (mainly in sy..