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Abstract : Background: According to published medical literature, there is variable incidence of heparin-induced thrombocytopenia (HIT), a life-threatening pro-thrombotic state, complicating unfractionated heparin (UFH) or low-molecular weight heparin (LMWH) use with immunogenic activation cascade evolving into arteriovenous thro..

Introduction: The von Willebrand Factor (vWF) is the biggest multimeric protein in the body and plays an important role in hemostasis. Its main functions are to bind to collagen, to platelet GPIb and to coagulation factor VIII (FVIII). Von Willebrand Disease (vWD) is the most common bleeding disorder in the Caucasian population. If,..

Abstract : BMI1 is a polycomb group (PcG) proteins which maintain self-renewal of stem cells, and is overexpressed in leukemia. This study was aimed to investigate the expression of BMI1 chronic myeloid leukemia (CML) and its clinical significance. Expression levels of BMI1 in 45 CML patients and 10 healthy controls were measured..

Abstract: Mutations in ras genes have been observed in a variety of cancers and were found to play an important role in human leukemogenesis and in preleukemic disease as myelodysplastic syndrome (MDS). The purpose of this study was to determine the prevalence of mutated K-ras oncogene in 30 patients suffering of myelodysplastic..

Abstract: Coagulation factor VIII (FVIII) inhibitors are the most severe complications of haemophilia A treatment. We studied the effect of a non-activated prothrombin concentrate (PCC) combined with FVIII in vitro. FVIII antibodies minimised the in vitro thrombin generation of standard human plasma and prolonged the lag phase a..

Abstract: Coagulation factor VIII (FVIII) inhibitors are the most severe complications of haemophilia A treatment. We studied the effect of a non-activated prothrombin concentrate (PCC) combined with FVIII in vitro. FVIII antibodies minimised the in vitro thrombin generation of standard human plasma and prolonged the lag phase a..

Abstract: Mutations in ras genes have been observed in a variety of cancers and were found to play an important role in human leukemogenesis and in preleukemic disease as myelodysplastic syndrome (MDS). The purpose of this study was to determine the prevalence of mutated K-ras oncogene in 30 patients suffering of myelodysplastic..

Abstract : BMI1 is a polycomb group (PcG) proteins which maintain self-renewal of stem cells, and is overexpressed in leukemia. This study was aimed to investigate the expression of BMI1 chronic myeloid leukemia (CML) and its clinical significance. Expression levels of BMI1 in 45 CML patients and 10 healthy controls were measured..

Introduction: The von Willebrand Factor (vWF) is the biggest multimeric protein in the body and plays an important role in hemostasis. Its main functions are to bind to collagen, to platelet GPIb and to coagulation factor VIII (FVIII). Von Willebrand Disease (vWD) is the most common bleeding disorder in the Caucasian population. If,..

Abstract : Background: According to published medical literature, there is variable incidence of heparin-induced thrombocytopenia (HIT), a life-threatening pro-thrombotic state, complicating unfractionated heparin (UFH) or low-molecular weight heparin (LMWH) use with immunogenic activation cascade evolving into arteriovenous thro..