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Abstract : Paclitaxel induced peripheral neuropathy (PIPN) is predominantly sensory. It usually appears with higher cumulative doses (>1,400 mg/m2), being less frequent with weekly regimens or lower doses.   Numbness, paresthesias and burning pain in a glove-and-stocking distribution, distal and symmetrical are the most frequen..

Abstract : TKIs against the human EGFR have become standard of care for patients with advanced EGFR mutant NSCLC. But despite the initial good results with first generation EGFR TKIs, patients’ cancers will progress after a median duration of response of around 12 months. And some patient will not even show response or only for..

Abstract : Triple-negative breast cancer is a separate entity that comprises several molecular subtypes driven by specific genetic alterations that might potentially be targeted. However, currently most patients continue to receive standard chemotherapy regimens. Neoadjuvant treatment is accepted for larger tumours and locally ad..

Abstract: Venous thromboembolism (VTE) is a major complication in cancer patients despite anticoagulation. In fact this is the second cause of death in them, only behind the malignancy itself. Therefore, optimal treatment is crucial. Low-molecular-weight heparin (LMWH) and direct oral anticoagulants (DOACs) have been included as..

Abstract : Metastatic colorectal cancer continues to be very frequent and although the improvements in its systemic treatment throughout the past decade have been noticeable, much needs still to be done. Patients’ survival has been prolonged with good quality of life, being still suitable for further treatment, thus further opt..

Introduction: CancerCancer is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via lymph or blood). These three malignant properties of cancers dif..

Abstract: Tumor angiogenesis leads to the development of pathologic vessels and blood flow insufficiency that results in tumor hypoxia, which can be an obstacle for effective radiotherapy. Tumor perfusion enhancement, through increased oxygenation, is a recognized method for tumor radiosensitization, but no clinically efficient ..

Abstract: Pyrrolidon carboxypeptidase (Pcp) (E.C 3.4.19.3) is an omega peptidase widely distributed in animal fluids and tissues, which hydrolyzes N-terminal pyroglutamic residues from biologically active peptides such as gonadotropin releasing hormone (GnRH). Previous results obtained in our laboratory showed a decrease of Pcp ..

Abstract : Adenomatosis (adenoma, papillary adenoma, florid papillomatosis) of the nipple is a rare benign disorder involving the nipple witch can be mistaken clinically for Paget's disease and pathologically be misinterpreted as an adenocarcinoma. It occurs mostly in middle-aged women and is extremely rare in adolescents and chi..

Abstract: Purpose:We examined the outcome of urethral dilation in elderly patients of the Igbo ethnic group in Nigeria for stricture that supervened on radical prostatectomy.Methods:In this study, 10 men aged 65 years or older with proved urethral strictures underwent dilation. Their disease followed radical prostatectomy during..