Research articles

By Dr. Abdulrahman A Meccawy
Corresponding Author Dr. Abdulrahman A Meccawy
Department of Surgery, Faculty of Medicine, King Abdel-Azez University, Jeddah, KSA, Jeddah, KSA - Saudi Arabia 000
Submitting Author Dr. Christine N Grace

Obesity, Bariatric, BMI, Fatty Liver, Diabetes Mellitus, Blood Pressure

Meccawy AA. Multiple Risk Factors for Non-Alcoholic Fatty Liver Disease in Obese Children and Adolescents. WebmedCentral GENERAL MEDICINE 2011;2(5):WMC001926
doi: 10.9754/journal.wmc.2011.001926
Submitted on: 15 May 2011 08:13:08 PM GMT
Published on: 20 May 2011 04:34:03 PM GMT


Background: Obesity is associated with many risk factors as fatty liver and a higher risk of death. Bariatric (weight loss) surgery for obesity is usually only considered in the last step to the morbid obese patients.
Objective: The aim of this study was to evaluate the association between obesity and liver fat content in order to evaluate the risk factors associated with obesity in both children and adults.
Design: The sample study was eligible for surgery that have a body mass index (BMI) greater than 40 or greater than 35 with some related conditions such as type fatty liver or type 2 diabetes mellitus which was detected by preoperative assessment which was conducted in 226 morbidly obese patients undergoing surgery for obesity. Assessment included blood tests in the form of investigations (blood picture, liver enzymes, lipid profile, blood sugar, insulin and glucagon hormones). Blood pressure was measured and liver ultrasound was done for the entire sample. Then the sample was divided into two groups according to liver condition (fatty liver and normal liver).
Results: Of the 226 patients enrolled in the study, 97 (43%) has fatty liver and 129 (57%) has normal liver structure. The body mass index (BMI) of both groups (fatty liver and normal liver) for “children and adults” was of very high significance (p-value = 0.000) with average of 44.42±0.71 and 49.89±1.1 for normal liver patients and fatty liver patients respectively. Obesity has proven to appear more in childhood 162 (76.8%), followed by adults 30 (4.2%), and then at the age of puberty 19 (9%) while 15 (6%) was not detected. Liver enzyme assessment revealed that only serum bilirubin showed significance (p-value = 0.006) between the 2 groups of patients. Diabetes showed significance (p-value = 0.031) in fatty liver patients. For lipid profile and hypertension there was no significance.
Conclusion: Obesity is becoming a major health problem as it is considered a risk factor in metabolic diseases and fatty liver. It is also becoming more popular in children increasing the incidence of its morbidity disorders due to the longer exposure. Bariatric surgery for morbid obesity with multiple risk factors is usually only considered when all other treatments have failed.

Source(s) of Funding

It is a registry study, 226 morbidly obese patients were recruited in the present study and they had undergone preoperative blood tests and liver ultrasound. Different tests were done for preoperative assessment which includes blood tests e.g. Hb level, blood sugar, TG, SGOT, SGPT, GGT, alkaline phosphatase, serum albumin and bilirubin, T4, TSH and the levels of cortisone both in the morning and evening. Blood pressure was measured and liver ultrasound was done which considered the most commonly used modality for the diagnosis of a fatty liver. The sonographic findings of fatty liver include increased echogenicity of the liver parenchyma and blurring of the vascular margins.
Enrolled patients were evaluated to see the incidence of fatty liver in obese patients. The data were analyzed based on overall and liver status (normal or fatty) to see if there is any significant difference between study groups in terms of abdominal ultrasound and liver function.

Competing Interests



This article has been downloaded from WebmedCentral. With our unique author driven post publication peer review, contents posted on this web portal do not undergo any prepublication peer or editorial review. It is completely the responsibility of the authors to ensure not only scientific and ethical standards of the manuscript but also its grammatical accuracy. Authors must ensure that they obtain all the necessary permissions before submitting any information that requires obtaining a consent or approval from a third party. Authors should also ensure not to submit any information which they do not have the copyright of or of which they have transferred the copyrights to a third party.
Contents on WebmedCentral are purely for biomedical researchers and scientists. They are not meant to cater to the needs of an individual patient. The web portal or any content(s) therein is neither designed to support, nor replace, the relationship that exists between a patient/site visitor and his/her physician. Your use of the WebmedCentral site and its contents is entirely at your own risk. We do not take any responsibility for any harm that you may suffer or inflict on a third person by following the contents of this website.

4 reviews posted so far

Obesity with fatty liver
Posted by Dr. Christine G Daood on 05 Jun 2011 09:16:47 AM GMT

Posted by Dr. Remon R Talaat on 20 May 2011 05:30:47 PM GMT

0 comments posted so far

Please use this functionality to flag objectionable, inappropriate, inaccurate, and offensive content to WebmedCentral Team and the authors.


Author Comments
0 comments posted so far


What is article Popularity?

Article popularity is calculated by considering the scores: age of the article
Popularity = (P - 1) / (T + 2)^1.5
P : points is the sum of individual scores, which includes article Views, Downloads, Reviews, Comments and their weightage

Scores   Weightage
Views Points X 1
Download Points X 2
Comment Points X 5
Review Points X 10
Points= sum(Views Points + Download Points + Comment Points + Review Points)
T : time since submission in hours.
P is subtracted by 1 to negate submitter's vote.
Age factor is (time since submission in hours plus two) to the power of 1.5.factor.

How Article Quality Works?

For each article Authors/Readers, Reviewers and WMC Editors can review/rate the articles. These ratings are used to determine Feedback Scores.

In most cases, article receive ratings in the range of 0 to 10. We calculate average of all the ratings and consider it as article quality.

Quality=Average(Authors/Readers Ratings + Reviewers Ratings + WMC Editor Ratings)