Submited on: 25 Jan 2011 11:00:36 AM GMT
Published on: 26 Jan 2011 08:34:28 PM GMT
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The authors have shown the role of TLR’s in health and diseases. The down regulation of TLR related molecules or signaling as well as their up regulation has been shown in some of the disorders. The TLR mutants may be more prone to certain infections. The role of TLR is of importance in evolving therapeutic drug approach in various diseases. The oxidative stress in various diseases may be one of the factors in TLR regulation. Oxidative stress has been observed in various diseases due to formation of oxidized products, often exhibited as lipid peroxidation and changes in the antioxidant system.  The paper is well written and includes good information on TLR.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    The major area of our research is on free radical generation and role of antioxidants in various diseases. There are various conditions of toxicity including heavy metal and pesticide intoxication, where free radicals are formed. Some other area of our work includes antioxidants in foods such as polyphenols, isoflavones etc, which may have contribution in lowering oxidative stress. 

  • How to cite:  Bhatnagar D .Expression of soluble Toll like receptors and its correlation with the oxidative stress in diseased conditions[Review of the article 'Expression Of Soluble Toll- Like Receptors And Its Correlation With The Oxidative Damage In Diseased Conditions ' by Khanna H].WebmedCentral 2011;2(5):WMCRW00724
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The review article from H.D Khanna' s lab is well written and covers many aspects with regard to the role of toll like receptors in various diseases. The article mab be accepted as such with the comment that words 'oxidative damage' can be deleted from the title as the paper is genral in nature. Further some references in the text like Whalen et al etc should mention the year also.

  • Competing interests:
    No competing interests.
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    1. Bhalla P., Garg M L, Dhawan D.K (2010). Protective role of lithium during aluminium-induced neurotoxicity. Neurochemistry International 56(2):256-62. 2. Chadha V.D and Dhawan D (2010).Uptake and retention of 65Zn in lithium-treated rat liver: Role of zinc. Digestive and liver disease 42(6):446-50 3. Malhotra A, Nair P, Dhawan D K (2009). Modulatory effects of curcumin and resveratrol on lung carcinogenesis in mice. Phytotherapy Research 4. Bhalla P., Dhawan D.K (2009). Protective role of lithium in ameliorating the aluminium-induced oxidative stress and histological changes in rat brain. Cell Mol Neurobiol 29:513?521. 5. Vijayta Dani Punita Bhalla, and D.K Dhawan (2008). Zinc modulates lithium-induced hepatotoxicity in rats. Liver International: 28(4):558-65 6. P. Sidhu, M L Garg and D K Dhawan (2006). Zinc protects rat liver histoarchitecture from detrimental effects of nickel. Biometals 19: 301-313. 7. Pardeep Sidhu, M.L.Garg and D.K.Dhawan (2004). Protective role of zinc in nickel induced hepatotoxicity in rats: Chemico-Biological Interactions 150, 199-209.
  • Experience and credentials in the specific area of science:

    we have worked extensively in the area of oxidative stress induced by heavy metals as well as in lung and colon cacners. However, we have not worked on toll like receptors.

  • How to cite:  Dhawan D .Expression of soluble toll like recptors and its correlation with the oxidative damage in diseased conditions.[Review of the article 'Expression Of Soluble Toll- Like Receptors And Its Correlation With The Oxidative Damage In Diseased Conditions ' by Khanna H].WebmedCentral 2011;2(4):WMCRW00675
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Review for paper by Karki et al
Posted by Dr. Ravi Kiran on 25 Mar 2011 07:42:41 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? No
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? No
  • Other Comments:

    The paper is well written and the findings are interesting. It is a significant advancement in the exsisting knowledge

     

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    None
  • Experience and credentials in the specific area of science:

    Yes

  • How to cite:  Kiran R .Review for paper by Karki et al[Review of the article 'Expression Of Soluble Toll- Like Receptors And Its Correlation With The Oxidative Damage In Diseased Conditions ' by Khanna H].WebmedCentral 2011;2(3):WMCRW00624
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