Submited on: 08 Feb 2011 08:08:57 AM GMT
Published on: 08 Feb 2011 09:38:27 PM GMT
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? No
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    I suggest:

    1.       Adding more information about the clinical and pathological data of the patients since the number of CTCs depends on the stage of the tumor.

    2.       Using gold standard technique such as IHC to justify for the number of the detected tumor cells

    3.       Consider the presence of ~20% of EpCAM negative cells

    4.       Blood samples from normal volunteers, patients with benign breast lesions would be advantageous.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have worked on CTCs from body fluids in bladder and colorectal cancer. I also worked on circulating RNA in breast cancer.

  • How to cite:  El-Abd E I.Comparing Sequential Steps For Detection Of Circulating Tumor Cells: More Specific Or Just Less Sensitive? [Review of the article 'Comparing Sequential Steps For Detection Of Circulating Tumor Cells: More Specific Or Just Less Sensitive? ' by Pachmann K].WebmedCentral 2011;2(2):WMCRW00451
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