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Submited on: 04 Nov 2015 11:56:26 AM GMT

Published on: 04 Nov 2015 12:03:58 PM GMT

Gait Analysis in Uner Tan Syndrome Cases with Key Symptoms of Ataxia, Quadrupedal Locomotion, Mental Impairment, and Dysarthric or No Speech

Posted by Dr. Juliana Dushanova on 10 Nov 2015 12:16:35 PM GMT Reviewed by WMC Editors

What are the main claims of the paper and how important are they?
The findings support the hypothesis coming from the evolution of bipedal locomotion in human beings and devolution in the quadrupedal locomotion in Uner Tan syndrome cases.
Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.
This study reports a new quantitative gait analysis of Uner Tan syndrome cases, healthy human subjectsand nonhuman primates.
Are the claims properly placed in the context of the previous literature?

Besides Uner Tan syndrome cases, a recently recognized pathological condition (or uniquely different neurological disorder), a number of diseases were considered as Darwinian disorders, such as Huntington's disease, depression, fatigue, epilepsy, obsessive compulsive disorder, schizophrenia, Alzheimer's disease.

Besides Uner Tan syndrome cases, a recently recognized pathological condition (or uniquely different neurological disorder), a number of diseases were considered as Darwinian disorders, such as Huntington's disease, depression, fatigue, epilepsy, obsessive compulsive disorder, schizophrenia,Alzheimer's disease.
Do the results support the claims? If not, what other evidence is required?

The author reports UTS cases walk with straight rather than flexed legs.

The results showed that the quadrupedal locomotion is mostly lateral sequence and similarities in gait characteristics with terrestrial primate locomotion.

The quadrupedal locomotion in healthy subjects has similarities with arboreal primate locomotion.

The author reports UTS cases walk with straight rather than flexed legs.

The results showed that the quadrupedal locomotion is mostly lateral sequence andsimilarities in gait characteristics with terrestrial primate locomotion.

The quadrupedal locomotion in healthy subjectshave similarities with arboreal primate locomotion.
If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

Yes
Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

Yes
Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

The paper could win by a head If the authors make a comparison with one of the diseases considered as Darwinian disorders.

The paper could win by a head If the authors make comparison with one of as Darwinian disorders.
Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?
Yes
Other Comments:
No
Competing interests:
.
Invited by the author to review this article? :
Yes
Have you previously published on this or a similar topic?:
No
References:
None
Experience and credentials in the specific area of science:

Different neurological disorders
How to cite: Dushanova J .Gait Analysis in Uner Tan Syndrome Cases with Key Symptoms of Ataxia, Quadrupedal Locomotion, Mental Impairment, and Dysarthric or No Speech [Review of the article 'Gait Analysis in Uner Tan Syndrome Cases with Key Symptoms of Ataxia, Quadrupedal Locomotion, Mental Impairment, and Dysarthric or No Speech ' by Tan U].WebmedCentral 2015;6(11):WMCRW003257

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