Submited on: 12 Feb 2013 04:18:25 PM GMT
Published on: 13 Feb 2013 07:15:18 AM GMT
 
Hypomagnesemia and Type 2 Diabetes
Posted by Dr. William J Maloney on 13 Feb 2014 07:20:44 PM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The aim of the authors is to analyze what effect hypomagnesemia has on Type 2 diabetes.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    No


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes- it would be a great lecture for medical students.


  • Other Comments:

    Hypomagnesemia has been implicated in adversely affecting diabetic complications.  The authors reccomend periodic determination of magnesium levels and appropriate magnesium replacement.  They feel that this will promote better glycemic control.  Oral magnesium replacement therapy corrects hypomagnesemia after a minimum treatment period of three months.

  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Clinical associate professor

  • How to cite:  Maloney W J.Hypomagnesemia and Type 2 Diabetes[Review of the article 'Hypomagnesemia and its Implications in Type 2 Diabetes Mellitus- A Review Article ' by Chhabra N].WebmedCentral 2013;5(2):WMCRW002979
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  • What are the main claims of the paper and how important are they?

    Implication of Hypomagnesemia in Type 2 Diabetes Mellitus.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    This is a review article.


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    N/A


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    N/A


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    More intricate details on hypomagnesemia  to be incorporated and better emphasis and schematization required, for improvisation. Obesity, risk factors associated with cardiovascular diseases, type 2 diabetes and renal nephropathy could have been incorporated. Reports on recent advances is lacking, (no recent reoprts have been quoted)


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes, for its clinical aspects


  • Other Comments:

    N/A

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:

    No

  • Experience and credentials in the specific area of science:

    N/A

  • How to cite:  Mani A .Review of Hypomagnesemia and its Implications in Type 2 Diabetes - A Review Article[Review of the article 'Hypomagnesemia and its Implications in Type 2 Diabetes Mellitus- A Review Article ' by Chhabra N].WebmedCentral 2013;4(4):WMCRW002695
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An excellent review by Dr Sahil
Posted by Prof. Gowrishankar Ramadurai on 21 Mar 2013 11:32:41 AM GMT

  • What are the main claims of the paper and how important are they?

    The author has undertaken a thorough review of the status of Magnesium influence on Diabetes. He has taken pains to refer to as many literature as possible to discuss the pros and cons of various previous results. In the context of growing need for effective control and minimization of diabetic disorder, this paper requires a sure reading.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    This is a review article. The author has carefully studied the existing literature and drawn conclusions based on them. One cannot attribute novelty to the claims as the author has only reviewed all the ealrlier works. However, his conclusions are acceptable.


  • Are the claims properly placed in the context of the previous literature?

    Yes. The authors conclusions are based on the previous results only. Inferences made from earlier studies are in tune.


  • Do the results support the claims? If not, what other evidence is required?

    Yes. It is evident that magnesium has a major role to play in the various fucntions of the body. Whether magensium deficiency leads to diabetes or the other way is not clear from the studies conducted by earlier authors. However, as in the case of iron, manganese, etc, magnesium has its implications on diabetes.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    NA


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes. I would say that the author has taken pains to collect information from as many literature as possible and derive conclusions. There could be few more works related to micronutrient status and their effects on diabetes. Nevertheless the authors' efforts are substantial to make his claims valid.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Since this is a review article, one need not expect any additional expermental results.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes, this article will help many groups of people working with diabetes control and management. This is an excellent review article. Definitely this is worth presenting in any conference and should draw the attention of many.


  • Other Comments:

    This paper can initiate lots of new studies relating diabetes with magnesium content of the whole body or the blood serum. Definitely there is scope for many more works to be done, and it would be interesting to even physicists who are engaged on trace element studies.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:

    1. http://www.webmedcentral.com/wmcpdf/Article_WMC002026.pdf 2. Research & Reviews: A Journal of Medicine, Volume 1, Issue 3, December 2011, Pages 1–11.

  • Experience and credentials in the specific area of science:
    None
  • How to cite:  Ramadurai G .An excellent review by Dr Sahil[Review of the article 'Hypomagnesemia and its Implications in Type 2 Diabetes Mellitus- A Review Article ' by Chhabra N].WebmedCentral 2013;4(3):WMCRW002630
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  • What are the main claims of the paper and how important are they?

    The paper dealt with Hypomagnesemia and its implications in Type 2 Diabetes Mellitus


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    It is an almost new argument.


  • Are the claims properly placed in the context of the previous literature?

    No


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    Not applicable


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    No, it should be more linked to review article guidelines writing


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Yes, a major adherence to review's guidelines will improve the paper


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes because of greater development of DM2 and the effects of Hypomagnesemia on body function.


  • Other Comments:

    Bari, February, 05th, 2013

    Title: “Hypomagnesemia and its implications in Type 2 Diabetes Mellitus- A Review Article”.

    Dear Editor,

    We have read through the manuscript and we think that the manuscript seems to show important and major lacking news:

    1. English should be revised in order to correct flaws.
    2. No review aims had been outlined at the end of introduction section.
    3. Although it is a review article, it lacks some characteristics of this kind of scientific work:

    a) No inclusion/exclusion criteria had been included. Please provide.
    b) No articles number had been provided, nor the number of excluded article.
    c) No flow-chart of the study research had been provided.
    d) No tables resembling data, main outcomes, results, etc of the theme treated had been provided

    The authors’ worte: “Other potential causes of lower serum magnesium in obese type 2 diabetic patients include reduced intestinal magnesium absorption secondary to higher fat intake and lower fiber intake(27), and diabetic autonomic neuropathy that may reduce oral intake and gastrointestinal absorption”. It would be more creditworthy to better describe the possible mechanism underlining the previous sentences. Please provide.

    The authors’ wrote: “Insulin may induce a shift of magnesium from the plasma to the erythrocytes and smooth muscle cells, both in vivo and in vitro, helping to explain the abnormalities in magnesium circulating levels frequently reported in diabetic patients”. It would be more clear of the authors try to better explain this mechanism in agreement with literature data.

    The authors should better describe the studies considered in order to manage their scientific aims. They should better evaluate the characteristics of the studies considered and, above all, the limitations of these researches. Please provide.

    Yours sincerely,
    Dr. Pietro Scicchitano

    Address:
    Piazza G. Cesare 11 - 70124 Bari Italy
    Tel +39-3339801846
    e-mail: piero.sc@hotmail.it

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I work in intensive care unit of Cardiology Department

  • How to cite:  Scicchitano P .Review of Hypomagnesemia and its implications in Type 2 Diabetes Mellitus- A Review Article[Review of the article 'Hypomagnesemia and its Implications in Type 2 Diabetes Mellitus- A Review Article ' by Chhabra N].WebmedCentral 2013;4(2):WMCRW002488
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  • What are the main claims of the paper and how important are they?

    Hypomagnesemia is both a cause and as well a consequence of diabetes mellitus. Early intervention by correcting the magnesium levels can improve the glycemic stataus and improve the qualty of life of the affected diabetic.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes, these claims are novel. Magnesium is a forgotten cation despite the fact that it has an important role in many physiological and biochemical processes vital to life. Magnesium has significant role in the release of insulin and utilization of glucose, deficiency of magnesium worsens glycemic status , but timely interventions and that too in highly economical ways can check the progresion of the disease and delay the onset of diabetes related complications.


  • Are the claims properly placed in the context of the previous literature?

    Yes there is a proper flow of information. The details are relevant and appropriately placed


  • Do the results support the claims? If not, what other evidence is required?

    Yes, the results are as per the presumptions.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No such deviations


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes the methodology is valid and advanced.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Since the topic is vast in itself, there is still a potential to explore more about the role of magnesium in Diabetes and associted complications but sufficiant details have been provided in the article.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes, the article is well written and outstanding indeed, ofcourse can be presented any where .


  • Other Comments:

    A close attention is required to be paid to magnesium levels in patients suffering from diabetes mellitus as well in those having the family history of diabetes mellitus considering its significant  role in metabolic reactions.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    27 years

  • How to cite:  Chhabra N .Hypomagnesemia and its Implications in Type 2 Diabetes Mellitus- A Review Article [Review of the article 'Hypomagnesemia and its Implications in Type 2 Diabetes Mellitus- A Review Article ' by Chhabra N].WebmedCentral 2013;4(1):WMCRW002456
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Hypermagnesemia and its Implications in Type 2 Diabetes Mellitus
Posted by Anonymous Reviewer on 12 Dec 2012 07:19:58 AM GMT

  • What are the main claims of the paper and how important are they?

    The main claims are that Hypermagnesemia can affect both Insulin secretion and Insulin action. In addition hyperglycemia reduces tubular reabsorbtion of Mg ion.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    It is a review article, so yes.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    NA


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    NA


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Estimation of hs-CRP can be included to prove inflamatory response


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes, because there are other studies which suggest that severe hypomagnesemia was strongly associated with elevated hs-CRP and hs-CRP decreases with mg supplimentation in diabetic patients, also low mg levels lead to the induction of proinflamatory response, so low mg levels can be a reason for diabetic complications.


  • Other Comments:

    Which estimation out of the total serum mg ion levels or intracellular mg estimation is better indicator of hypomagnesemia, is not well documented.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Have guided a thesis on a similar topic

  • How to cite:  Anonymous.Hypermagnesemia and its Implications in Type 2 Diabetes Mellitus[Review of the article 'Hypomagnesemia and its Implications in Type 2 Diabetes Mellitus- A Review Article ' by Chhabra N].WebmedCentral 2013;3(12):WMCRW002391
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