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This is an interesting article decribing to investigate the genetic polymorphism in SDF-1 in kenya population. The authors need to provide the datas as figures / as a table. Please also include the methodology used to calculate the frequency of polymorphism in different population of kenya. You need to change ml to microliter for Polymerase chain recation description. Can the author provide a graphical abstract showing the frequency of polymorphism of SDF-1 in different parts of Kenya. It will also support the data better if the author do sequencing of SDF-1 in different population to further validate the datas.
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Experience and credentials in the specific area of science:
I was working on polymorphism of a Abumndant larval transcript genes in parasite. But we performed sequencing of this genes in parasite derived from different geographical area.
- How to cite: Mishra P K.Occurrence of Stromal Derived Factor-1 Polymorphism In Kenyan Population- please provide the figures and tables for the result section[Review of the article 'Occurrence of Stromal Derived Factor-1 Polymorphism In Kenyan Population ' by Khamadi S].WebmedCentral 2012;3(4):WMCRW001750
It makes a first effort to determine the frequency of chemokine gene polymorphisms associated with resistance to HIV infection in the Kenian population.
The study is novel insofar as it addresses the Kenian population.
The claims are compatible with the preexisting literature.
The results are compatible with the conclusions. Data on HIV infection rates, which are discussed, were not presented, but are required to allow the reader to properly interpret the molecular data.
Not applicable
The methodology is valid for the molecular studies, but incomplete as to the epidemiology of HIV infection. Some of the P values reported approach the significance limit, and it would be advisable to enlarge the sample, because significant differences are likely to appear.
The paper is confusely written, with extensive reiteration of results in discussion.
Nomenclature must be correct, such as the misuse of mutagen (for mutation) and gene (for genotype). Results must be presented in Table form, and organized, with support of a concise text. The author must focus the actual data, rather than the theoretical background.
It is not an outstanding paper.
Discussions that go against current accepted standards of dealing with human populations should be eliminated, or at least made clear to why they are being raised. I refer to the suggestion that generation of a human population resistant to HIV should be achieved by planned interbreeding of polymorphism carriers. This is nonscientific, unethical and impractical, in my point of view, but I am open to reading arguments that defend inclusion of this proposal in a molecular biology report.
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1. Azevedo ZM, Moore DB, Lima FC, Cardoso CC, Bougleux R, Matos GI, Luz, RA, Xavier-Elsas P, Sampaio EP, Gaspar-Elsas MI, Moraes MO. 2012. Tumor Necrosis Factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: importance in ARDS in septic pediatric critically ill patients. Human Immunol. (in press).
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