Submited on: 04 Nov 2010 12:57:25 PM GMT
Published on: 06 Nov 2010 10:19:34 AM GMT
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Thank you for the invitation to review the manuscript: “Evolution of the Biosynthetic Glove for Hand Burns”.

     

    Very good review and well detailed background information.

    At the moment several skin substitute are available for the management of the burn wound and finding the right one still constitute a greater challenge.

     

    The incorporation of embryonic stem cells directly on the AWBAT Plus 3D matrix open doors for a new era in the treatment of the burn wound and definitely represent a new generation of the temporary skin substitutes. Besides the desirable properties of an ideal skin substitute like cost-effectiveness, adherence, permeability and infection control, the cosmetic outcome today, is added to the wish list with the same importance. This article provides a well documentation of the evolution of the burn wound. Further prospective clinical trials are required to validate the benefits of these findings.

  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    1. E. Aubrey Woodroof, PhD, MBA,a Richard P. Phipps, PhD,b John E. Greenwood, MD,c William Hickerson, MD,d and David Herndon, MDe The Search for an Ideal Temporary Skin Substitute: AWBAT Plus, a Combination Product Wound Dressing Medical Device Eplasty. 2010; 10: e60. Published online 2010 September 15. 2. Lal S, Barrow RE, Wolf SE, Chinkes DL, Hart DW, Heggers JP, Herndon DN Biobrane improves wound healing in burned children without increased risk of infection. Shock. 2000 Sep; 14(3):314-8; discussion 318-9. 3. Barret JP, Dziewulski P, Ramzy PI, Wolf SE, Desai MH, Herndon DN Biobrane versus 1% silver sulfadiazine in second-degree pediatric burns. Plast Reconstr Surg. 2000 Jan; 105(1):62-5. 4. Pereira C, Gold W, Herndon D. Review paper: burn coverage technologies: current concepts and future directions. J Biomater Appl. 2007 Sep; 22(2):101-21. 5. Branski LK, Mittermayr R, Herndon DN, Norbury WB, Masters OE, Hofmann M, Traber DL, Redl H, Jeschke MG. A porcine model of full-thickness burn, excision and skin autografting. Burns. 2008 Dec;34(8):1119-27. Epub 2008 Jul 10. 6. Branski LK, Herndon DN, Celis MM, Norbury WB, Masters OE, Jeschke MG. Amnion in the treatment of pediatric partial-thickness facial burns. Burns. 2008 May;34(3):393-9. Epub 2007 Oct 24.
  • Experience and credentials in the specific area of science:

    High

  • How to cite:  Herndon D .Evolution of The Biosynthetic Glove for Hand Burns[Review of the article 'Evolution Of The Biosynthetic Glove For Hand Burns ' by Thomas S].WebmedCentral 2010;2(1):WMCRW00352
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Posted by Dr. Paul Silverstein on 13 Dec 2010 01:17:13 PM GMT

  • Other Comments:

    The above paper traces the 30 year evolution of physiologic dressings in the treatment of hand burns. Burns of the hands and feet are unique because of the difficulty in applying dressings to fingers and toes that both provide therapeutic intervention while preserving mobility and allowing observation of the wound progression.  The Biobrane glove, introduced in the 1980's provided the above properties, and allowed the application of antimicrobial creams or solutions tot he burn injuries att he same time.  The current model of the glove (and stocking) now provide the addition of vitamins C & E, as well as Chondroitin sulfate and Immuno-10 to the collagen peptide structure of the membrane, to further promote healing in a moist environment, while preserving mobility of the fingers and toes, and visualization of the wound.This new dressing, named AWBAT Plus is currently being evaluated clinically.
    The major features of AWBAT therapy that may render it superior to other forms of burn therapy include:
    Starting mobility and rehabilitation physical therapy as soon after injury as the wound can be reasonably debrided of eschar;and  fewer dressing changes and therefore less pain for the patient to endure (resulting in less analgesic administration).
    The structure of the AWBAT Plus glove also provides a template for future incorporation and delivery of stem cells  to further support re-epitheliazation and faster healing of the burn wound, as well as a novel drug delivery system to protect the wound from colonization by pathologic microrganisms.-  I believe that this novel new approach to hand & foot burn therapy will form a valuable part of the burn surgeon's armamentarium.

  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:
    None
  • How to cite:  Silverstein P .Untitled[Review of the article 'Evolution Of The Biosynthetic Glove For Hand Burns ' by Thomas S].WebmedCentral 2010;1(12):WMCRW00242
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Posted by Dr. Carlos Blanco on 24 Nov 2010 01:34:24 PM GMT

  • Other Comments:
    Thank you for asking me to review the paper "EVOLUTION OF THE BIOSYNTHETIC GLOVE FOR HAND BURNS" by Woodroof, et al.
    1.AWBAT PLUS has been evaluated at the JMS Burn Center in Augusta, GA with very good results. The technology is comparable to TransCyte and found to stimulate wound healing better than other skin substitutes.
    2.The Biosynthetic Glove is very well constructed to save wound closure time, and is an excellent way to achieve early rehabilitation and function of the burn hand.
    3.The possibility of incorporating adult and embryonic stem cells in the 3D matrix offers promise to solving unmet needs in regenerative medicine.
    4.The AWBAT Plus Glove is a big improvement when compared to the BIOBRANE glove.
    5.The paper is well written and well researched with good background bibliography.
    6.No skin substitute is perfect. There can be different rates of healing under skin substitutes that are porous or meshed.
    7.There needs to have more prospective comparative studies to support the conclusions made by the authors.
    Thanks again for asking me to review this paper.
    Carlos Blanco MD
    CEO, Research Foundation
    JMS Burn Center
    Augusta, GA
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:
    None
  • How to cite:  Blanco C .Untitled[Review of the article 'Evolution Of The Biosynthetic Glove For Hand Burns ' by Thomas S].WebmedCentral 2010;1(11):WMCRW00172
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