Submited on: 28 Mar 2012 08:31:19 PM GMT
Published on: 29 Mar 2012 03:59:06 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    We have reported that two hybrid alleles of FUT2, secretor type α(1,2)fucosyltransferase gene, and SEC1, a pseudogene of FUT2. Chen et al. previously suggested that the non-B-DNA conformations plays an important role in initiating the homologous recombination of the SEC1-FUT2 hybrid alleles. This paper suggested another possible mechanism of the homologous recombination event of this locus. Co-localization of this putative PRDM9 -binding site and the non-B-DNA conformations provide convincing explanations of the highly unusual overlap of the SEC1-FUT2 hybrid alleles.

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  • Have you previously published on this or a similar topic?:
  • References:
    TaqMan-based real-time polymerase chain reaction for detection of FUT2 copy number variations: identification of novel Alu-mediated deletion. Soejima M, Koda Y. Transfusion. 2011 Apr;51(4):762-9. PMID: 20880207 Sec1-FUT2-Sec1 hybrid allele generated by interlocus gene conversion. Soejima M, Fujihara J, Takeshita H, Koda Y. Transfusion. 2008 Mar;48(3):488-92. PMID: 18067503 The fusion gene at the ABO-secretor locus (FUT2): absence in Chinese populations. Liu YH, Koda Y, Soejima M, Pang H, Wang BJ, Kim DS, Oh HB, Kimura H. J Hum Genet. 1999;44(3):181-4. PMID: 10319583 Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2). Koda Y, Soejima M, Wang B, Kimura H. Eur J Biochem. 1997 Jun 15;246(3):750-5. PMID: 9219535 Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency. Koda Y, Soejima M, Liu Y, Kimura H. Am J Hum Genet. 1996 Aug;59(2):343-50. PMID: 8755920 [PubMed - indexed for MEDLINE]
  • Experience and credentials in the specific area of science:

    We have found many single-nucleotide polymorphisms (SNPs) and genetic recombination in the coding region of the FUT2 locus.

  • How to cite:  Koda Y .Two possible mechainisms responsible for generation of SEC1-FUT2 hybrid alleles[Review of the article 'Identification of a Putative PRDM9-Binding Motif within the Homologous Recombination Hotspot in the SEC1 and FUT2 Genes ' by Férec C].WebmedCentral 2012;3(4):WMCRW001674
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