Submited on: 15 Sep 2011 09:31:58 PM GMT
Published on: 16 Sep 2011 10:53:15 AM GMT
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Nicely written article, with good description of imaging findings.
     
    Inclusion of alternative name Granulomatosis with polyangitis (GPA), will help in this article being more widely available for international audience.
     
     In 2011, the American College of Rheumatology (ACR), the American Society of Nephrology (ASN) and the European League Against Rheumatism (EULAR) resolved to change the name to granulomatosis with polyangiitis.
     
    The male is to female ratio of prevalence of Wagner's granulomatosis has been quoted in literature to as being 2:1  to 1:1, in various literature.
     
    Most commonly, GPA affects the nasal sinuses, lungs and kidneys, but can also affect the eyes, ears, skin, nerves, joints and other organs. Because of the variety of potential organ involvement, a wide range of symptoms can develop over days to months. For 90% of people, the first symptoms appear in the respiratory tract (e.g., nose and lungs) and include nasal congestion, frequent nosebleeds, shortness of breath, and cough that may produce bloody phlegm.
    The diagnosis of GPA is based on clinical features affecting typical organ sites together with the identification of blood vessel and tissue inflammation in those organs. Because of this,  a biopsy is often necessary for confirmation of the  characteristic changes.
     
    Due to overlap of imaging findings, some of these are misdiagnosed as malignancies. Before steroid treatment became available, mortality within one year was over 90%, with average survival being 5 months. Steroids prolonged average survival to 8 months. The introduction of cyclophosphamide (CYC) in the 1970s was a major breakthrough. Five-year survival is now 87%. Hence,  it is important  establish the diagnosis by imaging and histology

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have 18 years experience in radiology.

  • How to cite:  Koteyar S R.Review of case report- Wegener's granulmoatosis/ granulomatosis with polyangitis [Review of the article 'Case Report- Wegener's Granulomatosis in a Young Adult Patient ' by Verma S].WebmedCentral 2011;2(11):WMCRW001119
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This should be added to discussion:

    Prevalence of Wegener granulomatosis is about 3:100,000 and is more common in older patients.

     

    Pulmonary nodules mostly tend to cavitate, leaving irregular thick walls, but rarely calcify. There may occasionally be reticulonodular interstitial thickening. It may involve small and medium pulmonary arteries. It may also lead to wedge-shape pulmonary lesions. Lymphadenopathy is visible in up to 15% of patients. 

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have seen previously.

  • How to cite:  Aribas B .Case Report- Wegener's Granulomatosis in a Young Adult Patient [Review of the article 'Case Report- Wegener's Granulomatosis in a Young Adult Patient ' by Verma S].WebmedCentral 2011;2(11):WMCRW001117
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