The publication, “An Overview of the Basics of Generate Transgenic Hen 'Bioreactors'”, describing the artificial induction ( genetic engineering ) of human monoclonal antibody in eggs of transgenic hens, may open again the intriguing question how to explain former ( now almost historical) data of experiments performed on C57BL/10J unfertilized female mice, which exclusively produced a “natural” anti-histo-blood group-A antibody, either in conjunction with /or as response to its ovarian auto-reactive epitope  http://www.nature.com/nature/journal/v269/n5625/abs/269255a0.html.

Any interpretations of this old, but perhaps physiologically relevant observation remained up to now incomplete. In particular, the protein- and/or immunoglobulin classes, the cellular and topographical site of production of the murine “natural” anti-A antibody are still an open question. In fact, early ovariectomy, performed before the onset of puberty, always caused its immediate disappearance from the sera. This phenomenon, i.e. the rapid or even immediate antibody disappearance could hardly be explained by simply a removal of an antigenic stimulus combined with changing the hormonal situation. So the well known occurrence of “natural” antibody or “antibody-like” proteins, for instance, in fish eggs,  may raise a vague hypothesis of an ovarian site of spontaneous antibody production here even in a mammalian species, close to the auto-reactive epitope or in a molecular conjunction with it.

Genetic engineering may finally elucidate the mechanism, the cellular and topographical site of production of this particular murine “natural” anti-A antibody, and on this basis perhaps improve the knowledge about germline encoded “natural” antibodies, and should the situation arise, in bioreactors perhaps prepare their manufacturing.

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