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Coenzyme Q-10 Effects Endurance Running Performance

Posted by Prof. Jayendra R Gohil on 02 Nov 2011 05:13:48 AM GMT

The author himself is the subject of the study so some bias may occur; however in tis case study during running it does not seem to have occurred.
Second run is better than first; to rule out effect of extra month of training, experiment may be repeated with change of drug-month-order.
Does this drug come under banned list for athlets ? Is the drug residue testable in urine sample ?

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Studying Q-10 as anti-oxidant.
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Dear Professor Gohil, Thank you for your astute comments. I agree. One of the more difficult aspects I disclose is managing to peak performance in a control fashion. We know from years of research in the arenae of sports science literature, that a peak performance is one to two maybe three in a single year. I state this as disclosure because timing a peak effort is very difficult unless the athlete is very well experienced with knowing how to manage training for peak performance. I have been doing this since my first National Championship won in 1989, and 5-other National Championships in running since. That said, I am able to peak training efforts based on resting heart rates. If my resting heart rate is between 51-56, I am able to perform very close to peak level. If it is above 56 resting, then there is no sense in attempting a performance best due to lack of recovery. Each time I finished a timed run over this course, a measure of my pulse rate was 104-110% Max Heart Rate based on the Karvonnen formula (MHR = 220-HR). This explains why I could time 12-runs the first 90-days, but only 8-runs the second 90-days. Recovery to resting heart rate between 51-56 bpm is difficult to attain when training load has not attained recovery resting HR. Again thank you for your comment, I missed responding earlier for some reason. Bill Misner PhD

Responded by Dr. Bill Misner on 18 Nov 2011 11:55:36 PM

Good question - Author's reply

Posted by Dr. Bill Misner on 02 Nov 2011 09:02:29 PM GMT

This is an excellent question to "attempt" to answer. Some report that serum steady state blood levels CoQ10 do not correlate with the availability of either Ubiquinone or Ubiquinol for conversion to ATP in exercising muscles.

Coenzyme Q10 is not a banned substance according to the International Olympic Committee or the sub-committee for the USA Olympic organization. Coenzyme Q10 may be tested in blood serum levels. Some state that if it is deficient in working muscles, it may be tested by a series of urine tests.

I quote:

"In patients with mitochondrial dysfunction due to CoQ10 need, not only will the markers for CoQ10 (succinate, fumarate, malate, and hydroxymethylglutarate) elevate, but all of the compounds in the Krebs Cycle will elevate because electrons generated in the Krebs Cycle cannot continue into the electron transport chain to make ATP." [from Why Test for Coenzyme Q10? by Cass Nelson-Dooley, MS, Richard Lord, PhD, and J. Alexander Bralley, PhD @ http://www.metametrixinstitute.org/content/articles/WhyTestforCoenzymeQ10.pdf]

Bill Misner PhD

competing interests: None.
Invited by the author to make a review on this article? :
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Author of this Case Report.
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Reviewer's Instructions

Posted by Dr. Bill Misner on 03 Nov 2011 07:32:26 PM GMT

Dear Esteemed Reviewers,

To perform a review on the original manuscript, please clidk the pdf. version without reviews.

The manuscript posted with the reviewers reviews is NOT the original manuscript; it has several errors that occurred outside the author's control after the original manuscript was submitted.Please therefore perform your review on the Original Manuscript here:
"Coenzyme Q-10 Effects Endurance Running Performance - A Case Report"
http://www.webmedcentral.com/wmcpdf/Article_WMC002400.pdf

Bill Misner PhD

competing interests: None.
Invited by the author to make a review on this article? :
Experience and credentials in the specific area of science:
Author of this Case Report.
Publications in the same or a related area of science: No
References: None

Report abuse

Reviewer's Instructions

Posted by Dr. Bill Misner on 03 Nov 2011 07:33:02 PM GMT

Dear Esteemed Reviewers,

To perform a review on the original manuscript, please clidk the pdf. version without reviews.

The manuscript posted with the reviewers reviews is NOT the original manuscript; it has several errors that occurred outside the author's control after the original manuscript was submitted.Please therefore perform your review on the Original Manuscript here:
"Coenzyme Q-10 Effects Endurance Running Performance - A Case Report"
http://www.webmedcentral.com/wmcpdf/Article_WMC002400.pdf

Bill Misner PhD

competing interests: None.
Invited by the author to make a review on this article? :
Experience and credentials in the specific area of science:
Author of this Case Report.
Publications in the same or a related area of science: No
References: None

Report abuse

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