Inflammatory bowel disease (IBD) is chronic uncontrolled
inflammation characterized by intense mucosal
recruitment of activated leukocytes. Authors have
developed an in vitro model for IBD using colon cancer
cell line SW-620. Colon epithelial cell line HT-29
expressed elevated Interleukin-8 (IL-8) levels when induced with LPS
isolated from various bacterial strains. Authors have shown In this in vitro
model of IBD that IL-8 was playing a key role in
inflammation cascade. Action of anti-inflammatory
drug Ozagrel was studied and was found to block the
up regulation of IL-8. The paper has scientific meaning and can be recommend to an appropriate specialists. Some critical comments are the following : Fig.1 is hard to understand because the notices under columns are too small; the discussion should be written more briefly
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Inflammatory bowel disease (IBD) is chronic uncontrolled
inflammation characterized by intense mucosal
recruitment of activated leukocytes. Authors have
developed an in vitro model for IBD using colon cancer
cell line SW-620. Colon epithelial cell line HT-29
expressed elevated Interleukin-8 (IL-8) levels when induced with LPS
isolated from various bacterial strains. Authors have shown In this in vitro
model of IBD that IL-8 was playing a key role in
inflammation cascade. Action of anti-inflammatory
drug Ozagrel was studied and was found to block the
up regulation of IL-8. The paper has scientific meaning and can be recommend to an appropriate specialists. Some critical comments are the following : Fig.1 is hard to understand because the notices under columns are too small; the discussion should be written more briefly