Submited on: 05 Apr 2013 04:36:34 PM GMT
Published on: 06 Apr 2013 02:48:48 PM GMT

Inflammatory bowel disease (IBD) is chronic uncontrolled

inflammation characterized by intense mucosal

recruitment of activated leukocytes. Authors  have

developed an in vitro model for IBD using colon cancer

cell line SW-620. Colon epithelial cell line HT-29

expressed elevated Interleukin-8 (IL-8) levels when induced with LPS

isolated from various bacterial strains. Authors have shown In this in vitro

model of IBD that  IL-8 was playing a key role in

inflammation cascade. Action of anti-inflammatory

drug Ozagrel was studied and was found to block the

up regulation of IL-8. The paper has scientific meaning and can be recommend to  an appropriate specialists. Some critical comments are the following : Fig.1 is hard to understand because the notices under columns are too small; the discussion should be written more briefly

  • competing interests: No
  • Invited by the author to make a review on this article? :
  • Experience and credentials in the specific area of science: None
  • Publications in the same or a related area of science: No
  • References: None
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